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The map label for this gene is fkpA [H]

Identifier: 22127847

GI number: 22127847

Start: 4433330

End: 4434169

Strand: Direct

Name: fkpA [H]

Synonym: y3977

Alternate gene names: 22127847

Gene position: 4433330-4434169 (Clockwise)

Preceding gene: 22127845

Following gene: 22127848

Centisome position: 96.36

GC content: 45.83

Gene sequence:

>840_bases
TTGCTTGGGGTTAGAGTCCTTAAGCCAATGGAGAAATGGATGAAATCACTGTTTAAAGTAACGTTGCTGGCTACGGCCAT
GACGCTAACCCTGAATACCTCAACTGTTTTCGCTGCTGACGCAACCTCACCAGTAGTAACCAATAGCGCATTTAAAAATA
ATGATCAGCAATCTGCTTATGCATTAGGTGCGTCTTTGGGCCGCTATATGGATAATTCCCTGAAAGAACAAGAAAAATTG
GGGATTAAGTTGGATAAAGACCAGTTGATCGCTGGTGTGCAAGATGCTTTTGCTAACAAAAGCAAACTGACTGACGAAGA
GATCGAAAAAACCCTGCAAAATTTTGAAGCTCGGGTAAAAGCGTCTGCTCAAGCCAAAATGGAGCAAGATGCCAAAGAAA
ACGCGGATAAAGGCGCTAAGTACCGCGATACCTTTGCTAAAGAAAAAGGTGTGAAGAAAACCGCATCTGGCCTGCTGTAC
AAGGTAGAGAACGCCGGTACGGGTGATGCACCAAAAGACAGCGATACTGTTGTCGTTAACTACAAAGGCACTTTGGCTGA
CGGAACTGAGTTTGATAACTCATACAAACGTGGCGAGCCATTGTCTTTCCGTCTGGATGGCGTTATCCCAGGCTGGACTG
AAGGCCTGAAGCAAATCAAAAAAGGTGGCAAAATCACCTTGGTTATCCCGCCAGAACTGGCTTACGGCAAAGCAGGCGTC
CCTGGTATTCCTGCCAACTCTACTCTGATATTCGATGTAGAACTGCTGGATGTGAAAGCCGCAGCTAAAGCCGATGCTCA
AGAGCAACAGCCTGCGGTTGATACAAAAGCTAAGAAGTAA

Upstream 100 bases:

>100_bases
TCTTGTAGTAAAAAAAGTCTTAATATCACTTAATAGCATGAGTATTGAGATTGTTTTGTGTTCACACACACAGTTATAGT
ACATGTTACTCTTATAATCG

Downstream 100 bases:

>100_bases
TTTGACTTAGTCAGCATACTCTTCTCATAACCGTTACGATAATTGTCGTGACGGTTTTTTTTTGTGCGCTGGCAATTTAC
TTATCTGCTCGTTGATAACT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MLGVRVLKPMEKWMKSLFKVTLLATAMTLTLNTSTVFAADATSPVVTNSAFKNNDQQSAYALGASLGRYMDNSLKEQEKL
GIKLDKDQLIAGVQDAFANKSKLTDEEIEKTLQNFEARVKASAQAKMEQDAKENADKGAKYRDTFAKEKGVKKTASGLLY
KVENAGTGDAPKDSDTVVVNYKGTLADGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKQIKKGGKITLVIPPELAYGKAGV
PGIPANSTLIFDVELLDVKAAAKADAQEQQPAVDTKAKK

Sequences:

>Translated_279_residues
MLGVRVLKPMEKWMKSLFKVTLLATAMTLTLNTSTVFAADATSPVVTNSAFKNNDQQSAYALGASLGRYMDNSLKEQEKL
GIKLDKDQLIAGVQDAFANKSKLTDEEIEKTLQNFEARVKASAQAKMEQDAKENADKGAKYRDTFAKEKGVKKTASGLLY
KVENAGTGDAPKDSDTVVVNYKGTLADGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKQIKKGGKITLVIPPELAYGKAGV
PGIPANSTLIFDVELLDVKAAAKADAQEQQPAVDTKAKK
>Mature_279_residues
MLGVRVLKPMEKWMKSLFKVTLLATAMTLTLNTSTVFAADATSPVVTNSAFKNNDQQSAYALGASLGRYMDNSLKEQEKL
GIKLDKDQLIAGVQDAFANKSKLTDEEIEKTLQNFEARVKASAQAKMEQDAKENADKGAKYRDTFAKEKGVKKTASGLLY
KVENAGTGDAPKDSDTVVVNYKGTLADGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKQIKKGGKITLVIPPELAYGKAGV
PGIPANSTLIFDVELLDVKAAAKADAQEQQPAVDTKAKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=112, Percent_Identity=44.6428571428571, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224809327, Length=112, Percent_Identity=44.6428571428571, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4758384, Length=112, Percent_Identity=44.6428571428571, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224809331, Length=112, Percent_Identity=44.6428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI17149836, Length=105, Percent_Identity=45.7142857142857, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4503725, Length=105, Percent_Identity=45.7142857142857, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758380, Length=105, Percent_Identity=43.8095238095238, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503727, Length=185, Percent_Identity=34.5945945945946, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503729, Length=111, Percent_Identity=41.4414414414414, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI206725530, Length=91, Percent_Identity=45.0549450549451, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI17149844, Length=91, Percent_Identity=45.0549450549451, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI17149842, Length=91, Percent_Identity=45.0549450549451, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI8923659, Length=105, Percent_Identity=39.0476190476191, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=38.8888888888889, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1789745, Length=259, Percent_Identity=76.8339768339768, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI87082390, Length=215, Percent_Identity=38.1395348837209, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17540882, Length=116, Percent_Identity=41.3793103448276, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=46.1538461538462, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=108, Percent_Identity=41.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=92, Percent_Identity=52.1739130434783, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=104, Percent_Identity=45.1923076923077, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323482, Length=105, Percent_Identity=40.9523809523809, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=102, Percent_Identity=41.1764705882353, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=50, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=44.6808510638298, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=44.6808510638298, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356629, Length=111, Percent_Identity=46.8468468468468, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=41.9354838709677, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 30143; Mature: 30143

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGVRVLKPMEKWMKSLFKVTLLATAMTLTLNTSTVFAADATSPVVTNSAFKNNDQQSAY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCEECCHHCCCCHHHHH
ALGASLGRYMDNSLKEQEKLGIKLDKDQLIAGVQDAFANKSKLTDEEIEKTLQNFEARVK
HHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ASAQAKMEQDAKENADKGAKYRDTFAKEKGVKKTASGLLYKVENAGTGDAPKDSDTVVVN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCCCCEEEEE
YKGTLADGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKQIKKGGKITLVIPPELAYGKAGV
ECCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCC
PGIPANSTLIFDVELLDVKAAAKADAQEQQPAVDTKAKK
CCCCCCCEEEEEEEEEEHHHHHHCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MLGVRVLKPMEKWMKSLFKVTLLATAMTLTLNTSTVFAADATSPVVTNSAFKNNDQQSAY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCEECCHHCCCCHHHHH
ALGASLGRYMDNSLKEQEKLGIKLDKDQLIAGVQDAFANKSKLTDEEIEKTLQNFEARVK
HHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ASAQAKMEQDAKENADKGAKYRDTFAKEKGVKKTASGLLYKVENAGTGDAPKDSDTVVVN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCCCCEEEEE
YKGTLADGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKQIKKGGKITLVIPPELAYGKAGV
ECCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCC
PGIPANSTLIFDVELLDVKAAAKADAQEQQPAVDTKAKK
CCCCCCCEEEEEEEEEEHHHHHHCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]