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The map label for this gene is yheS [H]

Identifier: 22127839

GI number: 22127839

Start: 4427167

End: 4428552

Strand: Reverse

Name: yheS [H]

Synonym: y3969

Alternate gene names: 22127839

Gene position: 4428552-4427167 (Counterclockwise)

Preceding gene: 22127840

Following gene: 22127838

Centisome position: 96.26

GC content: 50.36

Gene sequence:

>1386_bases
TTGGATTTGGATGCCGTCATCTGGCTGGAAAAATGGCTGAAAAGCTACACCGGTACCTTGGTATTAATTTCCCATGACCG
CGATTTCCTTGATCCTATTATCGATAAGATTTTGCATATTGAACAGCAAACGCTGAATGAATATACCGGTAACTATTCAT
CGTTCGAACGCCAGCGCGCCACCAAACTGTCGCAACAACAATCGATGTATCAGCATCAGCAAGAAAAAGTGGCGCATTTA
CAAAGTTATATTGATCGCTTCCGGGCGCAAGCCACCAAAGCCAAGCAAGCCCAGAGCCGTATCAAGATGCTCGAGCGTAT
GGAGCTGATTGCCCCTGCACATGTGGATAATCCGTTCCACTTCAGTTTTCGTACACCAGAAAGCCTGCCAGATCCCTTGC
TGCGCATGGATAAAGTCAGTGCCGGTTACGGGGAAAACACCGTCTTACAGTCCATTAAACTCAACCTGGTGCCCGGTTCA
CGCATCGGTCTCTTGGGGCGTAATGGTGCCGGTAAATCAACGCTGATTAAATTATTGGCCGGGACGTTAGAACCGCAAAG
CGGTGAGATCGCCCTGTCCAAAGGCATTAAACTCGGTTACTTCGCCCAGCATCAGTTGGAGTTCTTACGGGCTGATGAAT
CACCGTTGCAGCATATGAGCCGCCTGGCCCCTAAAGAGTCAGAGCAGCAATTGCGCGATTATCTCGGTGGTTACGGCTTT
CAGGGCGATCAGGTGACCGACCCAACCGCCCGCTTTTCCGGTGGAGAGAAGGCGCGTTTGGTGCTGGCACTGATTATTTG
GCAACGGCCGAATCTGTTACTGCTGGATGAGCCCACCAACCATTTGGATTTGGACATGCGACAAGCCCTGACCGAGGCTC
TGATTGATTTTGAAGGCGCATTGGTGGTGGTTTCCCATGACCGTCATTTACTGCGCTCTACCACCGATGACCTCTATCTG
GTGCACGACGGTAAAGTGGAACAGTTCGATGGCGATCTGGAAGATTATCAGCAGTGGCTGGTGGATTCACAGCGCCAGCA
AAGCCAACAGGATAATCCGGCGAAGGAGCTATCGGGCAACAGCGCACAACAGCGTAAAGACCAAAAACGTCGCGATGCTG
AATTCCGCACTCAAACGCAGCCACTGCGTAAGCAGATTATGACGCTGGAAAAACAGATGGATAAACTCAGCACTGAGCTG
GCCGCTATCGAAGCACAGTTGGCGGATTCAGCACTGTATGATATTGCGCGCAAAGCGGACTTGACCCAATGCCTACTGCA
ACAAACGCAAGTGAAATCCAAGCTGGAAGAGACGGAAATGCAGTGGTTGGATGTGCAAGAACAGCTTGAAATACTGACTA
AAGAGTTTAGCGATGCCGATATATAA

Upstream 100 bases:

>100_bases
AACCGGTACGTTCATTTTCGGGTGGCTGGCGTATGCGTCTTAATCTGGCGCAGGCGCTGGTTTGCCGCTCTGATTTACTG
CTCTTGGATGAACCAACCAC

Downstream 100 bases:

>100_bases
TATCGGAAATATAGATATAACATCGCGAATGTAAATATGGCATCGTGAATATAGTCGTGCGAATTGAGTTAGAGTCGCAC
GACTAGAGCGGCGTGATTTT

Product: ATP-binding component of a transport system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MDLDAVIWLEKWLKSYTGTLVLISHDRDFLDPIIDKILHIEQQTLNEYTGNYSSFERQRATKLSQQQSMYQHQQEKVAHL
QSYIDRFRAQATKAKQAQSRIKMLERMELIAPAHVDNPFHFSFRTPESLPDPLLRMDKVSAGYGENTVLQSIKLNLVPGS
RIGLLGRNGAGKSTLIKLLAGTLEPQSGEIALSKGIKLGYFAQHQLEFLRADESPLQHMSRLAPKESEQQLRDYLGGYGF
QGDQVTDPTARFSGGEKARLVLALIIWQRPNLLLLDEPTNHLDLDMRQALTEALIDFEGALVVVSHDRHLLRSTTDDLYL
VHDGKVEQFDGDLEDYQQWLVDSQRQQSQQDNPAKELSGNSAQQRKDQKRRDAEFRTQTQPLRKQIMTLEKQMDKLSTEL
AAIEAQLADSALYDIARKADLTQCLLQQTQVKSKLEETEMQWLDVQEQLEILTKEFSDADI

Sequences:

>Translated_461_residues
MDLDAVIWLEKWLKSYTGTLVLISHDRDFLDPIIDKILHIEQQTLNEYTGNYSSFERQRATKLSQQQSMYQHQQEKVAHL
QSYIDRFRAQATKAKQAQSRIKMLERMELIAPAHVDNPFHFSFRTPESLPDPLLRMDKVSAGYGENTVLQSIKLNLVPGS
RIGLLGRNGAGKSTLIKLLAGTLEPQSGEIALSKGIKLGYFAQHQLEFLRADESPLQHMSRLAPKESEQQLRDYLGGYGF
QGDQVTDPTARFSGGEKARLVLALIIWQRPNLLLLDEPTNHLDLDMRQALTEALIDFEGALVVVSHDRHLLRSTTDDLYL
VHDGKVEQFDGDLEDYQQWLVDSQRQQSQQDNPAKELSGNSAQQRKDQKRRDAEFRTQTQPLRKQIMTLEKQMDKLSTEL
AAIEAQLADSALYDIARKADLTQCLLQQTQVKSKLEETEMQWLDVQEQLEILTKEFSDADI
>Mature_461_residues
MDLDAVIWLEKWLKSYTGTLVLISHDRDFLDPIIDKILHIEQQTLNEYTGNYSSFERQRATKLSQQQSMYQHQQEKVAHL
QSYIDRFRAQATKAKQAQSRIKMLERMELIAPAHVDNPFHFSFRTPESLPDPLLRMDKVSAGYGENTVLQSIKLNLVPGS
RIGLLGRNGAGKSTLIKLLAGTLEPQSGEIALSKGIKLGYFAQHQLEFLRADESPLQHMSRLAPKESEQQLRDYLGGYGF
QGDQVTDPTARFSGGEKARLVLALIIWQRPNLLLLDEPTNHLDLDMRQALTEALIDFEGALVVVSHDRHLLRSTTDDLYL
VHDGKVEQFDGDLEDYQQWLVDSQRQQSQQDNPAKELSGNSAQQRKDQKRRDAEFRTQTQPLRKQIMTLEKQMDKLSTEL
AAIEAQLADSALYDIARKADLTQCLLQQTQVKSKLEETEMQWLDVQEQLEILTKEFSDADI

Specific function: Unknown

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=352, Percent_Identity=36.3636363636364, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI27881506, Length=361, Percent_Identity=35.4570637119114, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI10947137, Length=369, Percent_Identity=34.9593495934959, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI10947135, Length=367, Percent_Identity=33.7874659400545, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI69354671, Length=367, Percent_Identity=33.7874659400545, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI153792144, Length=246, Percent_Identity=29.6747967479675, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789751, Length=450, Percent_Identity=80, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1787041, Length=342, Percent_Identity=33.9181286549708, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI2367384, Length=346, Percent_Identity=31.5028901734104, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787182, Length=422, Percent_Identity=25.3554502369668, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1788165, Length=191, Percent_Identity=34.0314136125654, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI48994997, Length=249, Percent_Identity=26.9076305220884, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787164, Length=215, Percent_Identity=29.7674418604651, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789672, Length=218, Percent_Identity=26.1467889908257, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081791, Length=225, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081709, Length=225, Percent_Identity=24, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787547, Length=200, Percent_Identity=25.5, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787758, Length=208, Percent_Identity=26.4423076923077, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789891, Length=208, Percent_Identity=27.4038461538462, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786803, Length=218, Percent_Identity=27.0642201834862, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994883, Length=226, Percent_Identity=25.2212389380531, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87081782, Length=241, Percent_Identity=27.3858921161826, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788506, Length=257, Percent_Identity=24.5136186770428, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786703, Length=213, Percent_Identity=29.1079812206573, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17553372, Length=340, Percent_Identity=40, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17555318, Length=363, Percent_Identity=35.2617079889807, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17559834, Length=364, Percent_Identity=31.5934065934066, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI115533592, Length=267, Percent_Identity=25.0936329588015, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320874, Length=348, Percent_Identity=37.3563218390805, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6321121, Length=345, Percent_Identity=33.0434782608696, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6325030, Length=250, Percent_Identity=30, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324314, Length=75, Percent_Identity=48, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323278, Length=101, Percent_Identity=36.6336633663366, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666836, Length=341, Percent_Identity=36.3636363636364, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24642252, Length=366, Percent_Identity=37.1584699453552, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI18859989, Length=366, Percent_Identity=37.1584699453552, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24641342, Length=357, Percent_Identity=33.0532212885154, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI116007184, Length=200, Percent_Identity=28, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221500365, Length=200, Percent_Identity=28, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574259, Length=244, Percent_Identity=26.6393442622951, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 52715; Mature: 52715

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDAVIWLEKWLKSYTGTLVLISHDRDFLDPIIDKILHIEQQTLNEYTGNYSSFERQRA
CCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TKLSQQQSMYQHQQEKVAHLQSYIDRFRAQATKAKQAQSRIKMLERMELIAPAHVDNPFH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
FSFRTPESLPDPLLRMDKVSAGYGENTVLQSIKLNLVPGSRIGLLGRNGAGKSTLIKLLA
EECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHH
GTLEPQSGEIALSKGIKLGYFAQHQLEFLRADESPLQHMSRLAPKESEQQLRDYLGGYGF
HCCCCCCCCEEHHCCCEECHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
QGDQVTDPTARFSGGEKARLVLALIIWQRPNLLLLDEPTNHLDLDMRQALTEALIDFEGA
CCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCE
LVVVSHDRHLLRSTTDDLYLVHDGKVEQFDGDLEDYQQWLVDSQRQQSQQDNPAKELSGN
EEEEECCHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCC
SAQQRKDQKRRDAEFRTQTQPLRKQIMTLEKQMDKLSTELAAIEAQLADSALYDIARKAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQCLLQQTQVKSKLEETEMQWLDVQEQLEILTKEFSDADI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLDAVIWLEKWLKSYTGTLVLISHDRDFLDPIIDKILHIEQQTLNEYTGNYSSFERQRA
CCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TKLSQQQSMYQHQQEKVAHLQSYIDRFRAQATKAKQAQSRIKMLERMELIAPAHVDNPFH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
FSFRTPESLPDPLLRMDKVSAGYGENTVLQSIKLNLVPGSRIGLLGRNGAGKSTLIKLLA
EECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHH
GTLEPQSGEIALSKGIKLGYFAQHQLEFLRADESPLQHMSRLAPKESEQQLRDYLGGYGF
HCCCCCCCCEEHHCCCEECHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
QGDQVTDPTARFSGGEKARLVLALIIWQRPNLLLLDEPTNHLDLDMRQALTEALIDFEGA
CCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCE
LVVVSHDRHLLRSTTDDLYLVHDGKVEQFDGDLEDYQQWLVDSQRQQSQQDNPAKELSGN
EEEEECCHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCC
SAQQRKDQKRRDAEFRTQTQPLRKQIMTLEKQMDKLSTELAAIEAQLADSALYDIARKAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQCLLQQTQVKSKLEETEMQWLDVQEQLEILTKEFSDADI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]