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The map label for this gene is folB [H]

Identifier: 22127405

GI number: 22127405

Start: 3916409

End: 3916771

Strand: Reverse

Name: folB [H]

Synonym: y3531

Alternate gene names: 22127405

Gene position: 3916771-3916409 (Counterclockwise)

Preceding gene: 161484752

Following gene: 22127404

Centisome position: 85.13

GC content: 50.14

Gene sequence:

>363_bases
GTGATGGACATCGTATTTATTGAGGAACTCAGTGTCATAACCACCATCGGGGTTTATGACTGGGAGCAGACCATCCAGCA
GAAGCTGGTGTTCGATATCGAAATGGGCTGGGATAACCGTAAAGCGGCGGGCAGTGATGATGTCAATGACTGCCTGAGTT
ACGCTGATATCAGTGAGGCGGTGATACAACATGTCGGCTCACAGCGTTTTGCATTGGTAGAGCGGGTCGCTGAAGAGGTA
GCCGAGTTGTTATTACGACGCTTTAATTCGCCGTGGGTACGCATCAAAGTTAGCAAGCCGGGGGCTGTTGCCCAAGCCAA
AAATGTTGGTGTAATTATTGAACGTGGCCAACGGCTAAGCTGA

Upstream 100 bases:

>100_bases
CCGCCCCGTTGAATAATGGTCGTTTTAATCGCAACATCAGTGGATAATACGCATATTCGGCTGGAAGTGGTATCCGGCAG
GCACAAAAACAGAGAATGAC

Downstream 100 bases:

>100_bases
CCTTTTGTCGCCATATGACATAAAAATATCATTCTGCATTGATAATGTTGTCTGATTGTGTCGAGGTTCGTGATAAATTT
TCTGTATCCTTCTTAACTTG

Product: bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 120; Mature: 120

Protein sequence:

>120_residues
MMDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAVIQHVGSQRFALVERVAEEV
AELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS

Sequences:

>Translated_120_residues
MMDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAVIQHVGSQRFALVERVAEEV
AELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS
>Mature_120_residues
MMDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAVIQHVGSQRFALVERVAEEV
AELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=118, Percent_Identity=84.7457627118644, Blast_Score=206, Evalue=4e-55,
Organism=Escherichia coli, GI1788641, Length=110, Percent_Identity=27.2727272727273, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13523; Mature: 13523

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEA
CCCEEEHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
VIQHVGSQRFALVERVAEEVAELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MMDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEA
CCCEEEHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
VIQHVGSQRFALVERVAEEVAELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]