Click here to switch to the map view.

The map label for this gene is hldE [H]

Identifier: 22127398

GI number: 22127398

Start: 3906858

End: 3908303

Strand: Reverse

Name: hldE [H]

Synonym: y3524

Alternate gene names: 22127398

Gene position: 3908303-3906858 (Counterclockwise)

Preceding gene: 161484753

Following gene: 22127397

Centisome position: 84.95

GC content: 52.97

Gene sequence:

>1446_bases
TTGGGGGGCAAATGTATGAAAGTCACGCTGCCTGATTTTCGCCGTGCTGGTGTATTAGTCGTGGGTGATGTCATGTTAGA
CCGCTACTGGTACGGGCCAACCTGCCGGATTTCACCAGAAGCACCTGTGCCTGTAGTGAAAGTCGATACCATCGAAGAGC
GCCCTGGTGGTGCAGCAAACGTTGCGATGAATATTGCCTCCCTTGGCGCGGTTGCGCGCTTAGTCGGGTTGACCGGCATT
GACGATGCGGCGCGTGCGCTGATCTGCAAGCTGAGCGAAGTTCGGGTGCGTTGCGATTTTGTCTCGGTACCCACTCACCC
GACCATTACCAAATTACGGGTACTTTCCCGTAACCAGCAGTTAATCCGCCTGGATTTTGAAGAGGGCTTTGACGGTGTTG
ATCCCACGCCGATATTCGAGCGCATTCAACTGGCGTTGCCACAGATTGGCGCGCTGGTGCTGTCCGATTATGCCAAGGGG
GCATTGAACAGCGTACAGCCGATGATCCAACTGGCACGTAAAGCGAATGTCCCGGTTTTGATTGATCCGAAAGGCAGTGA
TTTTGAGCGCTACCGTGGTGCCACATTGTTGACGCCGAATTTGTCTGAATTTGAAGCAGTGGTAGGGCGCTGTAAAAATG
AAGAAGAGTTGGTTAACCGCGGTATGCAACTGGTGGCAGATTTCGAACTTTCAGCATTGCTGGTGACCCGTTCTGAACAA
GGCATGACCTTGTTGCAACTGGGTAAACCGCCGCTACATTTGCCGACTCAGGCAAAAGAAGTGTTTGATGTGACCGGTGC
TGGCGATACGGTTATTGGCGTGCTGGCTGCCGCGCTGGCTGCAGGTAACAGCCTGGAAGAGTCATGTTTCCTGGCTAATG
CTGCCGCCGGTGTAGTGGTGGGTAAATTGGGTACCTCGACCGTTTCTCCGATTGAGTTGGAAAACGCGATCCGTGGCCGT
GCAGAAACCGGTTTTGGGGTGATGGATGAGCAGCAACTGAAAATAGCGGTTGCGCAGGCTCGCCAGCGTGGGGAGAAGGT
GGTCATGACCAATGGCATTTTTGACATCCTCCATGCAGGCCATGTTTCTTATCTGGCCAATGCCCGTAAGCTGGGGGATC
GCCTGATTGTGGCGGTGAACAGCGATGCTTCCACCAAGCGGCTGAAAGGTGAAAAGCGGCCGGTTAATCCATTAGAACAA
CGTATGGTTGTCTTGGGTGCGTTGGAAGCGGTGGATTGGGTCGTGCCCTTTGAAGAAGATACGCCACAGCGTTTAATTGC
TGATATTTTGCCCGATCTGTTAGTCAAAGGCGGCGATTATAAGCCCCATGAAATTGCAGGTAGCGAAGAAGTCTGGGCCG
CCGGTGGCGAGGTTAAGGTACTGAATTTTGAAGATGGTGTCTCTACCACCAATATTATTCAGTCGATCAAAAACGGCCGC
GGCTAA

Upstream 100 bases:

>100_bases
TAATGGAATATAAGGTGCCTGTGATATTATTTGGCGCTATATGATGAACACAATATTGGAGCGAAGGGATGGGTGCATTC
GGGGTTAATAACAACTCAGG

Downstream 100 bases:

>100_bases
GTCAGCGCCAGAGCGCTGGCGCATAAGGATGTGGCAGTGGGTGGGTTAAAGCAAGAGTTAAGTCTGGCGCAAGGCGTTGG
GTTGTTATCCACTTCCCTGT

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MGGKCMKVTLPDFRRAGVLVVGDVMLDRYWYGPTCRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGI
DDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKG
ALNSVQPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQ
GMTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGR
AETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQ
RMVVLGALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGR
G

Sequences:

>Translated_481_residues
MGGKCMKVTLPDFRRAGVLVVGDVMLDRYWYGPTCRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGI
DDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKG
ALNSVQPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQ
GMTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGR
AETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQ
RMVVLGALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGR
G
>Mature_480_residues
GGKCMKVTLPDFRRAGVLVVGDVMLDRYWYGPTCRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGAVARLVGLTGID
DAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGA
LNSVQPMIQLARKANVPVLIDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQG
MTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVVGKLGTSTVSPIELENAIRGRA
ETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQR
MVVLGALEAVDWVVPFEEDTPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGRG

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=475, Percent_Identity=86.1052631578947, Blast_Score=835, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51695; Mature: 51564

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGKCMKVTLPDFRRAGVLVVGDVMLDRYWYGPTCRISPEAPVPVVKVDTIEERPGGAAN
CCCCEEEEECCCCCCCCEEEEEHHHHHHEECCCCEEECCCCCCCEEEEECCCCCCCCHHH
VAMNIASLGAVARLVGLTGIDDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQ
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHCCCCE
LIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSVQPMIQLARKANVPVL
EEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQ
ECCCCCCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHCCHHEEECCCEEEEEEEECCC
GMTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVV
CCEEEECCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
GKLGTSTVSPIELENAIRGRAETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAG
ECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
HVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVLGALEAVDWVVPFEED
HHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCC
TPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGR
CHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCC
G
C
>Mature Secondary Structure 
GGKCMKVTLPDFRRAGVLVVGDVMLDRYWYGPTCRISPEAPVPVVKVDTIEERPGGAAN
CCCEEEEECCCCCCCCEEEEEHHHHHHEECCCCEEECCCCCCCEEEEECCCCCCCCHHH
VAMNIASLGAVARLVGLTGIDDAARALICKLSEVRVRCDFVSVPTHPTITKLRVLSRNQQ
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHCCCCE
LIRLDFEEGFDGVDPTPIFERIQLALPQIGALVLSDYAKGALNSVQPMIQLARKANVPVL
EEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IDPKGSDFERYRGATLLTPNLSEFEAVVGRCKNEEELVNRGMQLVADFELSALLVTRSEQ
ECCCCCCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHCCHHEEECCCEEEEEEEECCC
GMTLLQLGKPPLHLPTQAKEVFDVTGAGDTVIGVLAAALAAGNSLEESCFLANAAAGVVV
CCEEEECCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
GKLGTSTVSPIELENAIRGRAETGFGVMDEQQLKIAVAQARQRGEKVVMTNGIFDILHAG
ECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
HVSYLANARKLGDRLIVAVNSDASTKRLKGEKRPVNPLEQRMVVLGALEAVDWVVPFEED
HHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCC
TPQRLIADILPDLLVKGGDYKPHEIAGSEEVWAAGGEVKVLNFEDGVSTTNIIQSIKNGR
CHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA