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The map label for this gene is slrP [H]

Identifier: 22127273

GI number: 22127273

Start: 3759123

End: 3761003

Strand: Reverse

Name: slrP [H]

Synonym: y3397

Alternate gene names: 22127273

Gene position: 3761003-3759123 (Counterclockwise)

Preceding gene: 22127274

Following gene: 22127270

Centisome position: 81.75

GC content: 46.25

Gene sequence:

>1881_bases
ATGAATCTATCAAATATAACGTCGAACGTGTCAATGCCGAACATCGAGCCAGACCGTGAAATCCATTCTGCACGGACATC
AACAGCAGCCTTAACTCCGGCTGACTATTATGCAATATGGGAAAAATGGGAAAGCGAAGCAATACCTGGTACTGACGAAC
AACGGCGCTTCGCCGTGGAATGCATGAAAGATTGCCTGGAAAAAAATACCTATCACCTCTGTCTCCGTGATCTTAATTTG
GCCTCATTACCAGACATTCTGCCGCCGTGTAACGAACTGGATCTCATGGGTAATAAGTTAACTGAGTTGCCAGCAACACT
GCCCGACAACCTGCAAAAACTGAATGCTTCTTTTAATCAACTGCGTACATTACCGGATACATTACCGGCCTCGCTGTTAT
CTCTAAATGTGTACGGAAATGAACTAGAACGGCTCCCTGAGTCGCTACCTGAAGGGCTAAAAGAATTAGACGTTAATGAT
AATGAGTCACTGCAACTCCCAAATCGCTTGCCCCCGAATCTGGAGTCTCTTGGTATTGCAAGCTGTGGCTTAACTGAACT
GCCTACACTGCCGAACAGTTTGAAAAGACTGGATGCGGATAGTAATCAACTGCGCACATTGCCCGATACATTGCCAATAT
CGCTATTAAATCTAAGTGTGACCAGTAATCAACTCACACAACTCCCCGAGACATTGCCCGCCTCGCTGTCATTTTTAATG
GTATTGAGCAATAGGCTCACAAAACTGCCAGAAAATTTACCCGGTAGTTTAAGGTGTATCAGCGCTGAATATAATCAATT
ATCCCAACTTCCCGACCTGGCCCGTCTGCCCCAAAACTGTGAAATTCTCTTAGAAGGTAACCCTCTGTCTACCAGCACAC
TGCAGGTACTACAACATCTCCGTATTAACCCGTATTATCAGGGGCCACGGATTAACTGGAGCGAATTAGACAATCTACCA
CCAGCGAGTCTCCGTAACATTGTTGCCACCTGGTTGCCGCCGGAACAACAAAATAGGTTGGCAGGAGATTGGGCAAATAT
CGAGACAGAAGCTAACTCAGCCGCTTTTAGCGTTTTTCTTCACCGTTTGGCTACCACTCAAAACGCAAATAATATCCCTG
AATTTAAACAACAAATTGCGGCATGGTTGTTGCAATTGGCTGACTCACCTACTCTACGTGAGCAGACCTTTCTTATTGCT
CAGGAAGCAAGCGCGACCTGTGAAGACCGCATTACCTTGACGCATAACGATATGCAAAAGGCAGTCATGCTCCATGAGGT
CGAAAAGGGGAAATATGATGAAAAACTACCTGAACTGATGGCGCGTGGCCGAGAGATGTTCCGTCTGGAACAACTTGAGA
ATATTGCCCGCGAAAAAGTAAAAATACTAAAAACACTGAATGTAAATTCAGTCGATGATATCGAAGTCTATCTCGCCTAT
CAGGTCAAACTGCTCAATTCCTTACAGCTCTCCTCGGTAAACAAAGAAATGCGCTTCTTTGGCGTATCACATGTGACAGC
AGACGATTTACTGAGCGCAGAAACCCGGGTGAAAACTGCGGAAAACCAAGATTTCTCGCGCTGGCTATCACAATGGTCTC
CGTGGAAAAGCGTGGTGCAACGTATTGAGCCTGAACGTTATGCTGCTGCGGTCGAAAAGCAGTACCACGCACTGGAGAAT
ATTTACCCAGATAAACTGGCGGCTGAATTGGCAGCCAACGGGATGACGGGCGATGTGGATGCCAACCGCATTGTCGGCAA
AAGAATCAACGATGAGCTCATGGGGGAGATCGATATGGCCCTAACTCATGAGGTTCTCTCTGCCAAAGGAGCCTCCTCCT
TATTAGATAATCTGTGGATGGAATATCTAATCTCGCCTTGA

Upstream 100 bases:

>100_bases
CAGTAAGCTAAAAATACCAGTAGTAGACCTTATCCACCCCCTGTTATTTATCAGCCAAAATAATACCTATAAGGCTTATT
AAGGAAGAGGTTTTAATACA

Downstream 100 bases:

>100_bases
TACTGTACGGTCCGTTATCCCATAAAAAACGGCGCATATTCTGTCCTGCAATATGCGCCGTTGATCATCATGTCGTTAGT
GGTTAATTACCTGACGATAA

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MNLSNITSNVSMPNIEPDREIHSARTSTAALTPADYYAIWEKWESEAIPGTDEQRRFAVECMKDCLEKNTYHLCLRDLNL
ASLPDILPPCNELDLMGNKLTELPATLPDNLQKLNASFNQLRTLPDTLPASLLSLNVYGNELERLPESLPEGLKELDVND
NESLQLPNRLPPNLESLGIASCGLTELPTLPNSLKRLDADSNQLRTLPDTLPISLLNLSVTSNQLTQLPETLPASLSFLM
VLSNRLTKLPENLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRINPYYQGPRINWSELDNLP
PASLRNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFLHRLATTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIA
QEASATCEDRITLTHNDMQKAVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAY
QVKLLNSLQLSSVNKEMRFFGVSHVTADDLLSAETRVKTAENQDFSRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALEN
IYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDMALTHEVLSAKGASSLLDNLWMEYLISP

Sequences:

>Translated_626_residues
MNLSNITSNVSMPNIEPDREIHSARTSTAALTPADYYAIWEKWESEAIPGTDEQRRFAVECMKDCLEKNTYHLCLRDLNL
ASLPDILPPCNELDLMGNKLTELPATLPDNLQKLNASFNQLRTLPDTLPASLLSLNVYGNELERLPESLPEGLKELDVND
NESLQLPNRLPPNLESLGIASCGLTELPTLPNSLKRLDADSNQLRTLPDTLPISLLNLSVTSNQLTQLPETLPASLSFLM
VLSNRLTKLPENLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRINPYYQGPRINWSELDNLP
PASLRNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFLHRLATTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIA
QEASATCEDRITLTHNDMQKAVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAY
QVKLLNSLQLSSVNKEMRFFGVSHVTADDLLSAETRVKTAENQDFSRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALEN
IYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDMALTHEVLSAKGASSLLDNLWMEYLISP
>Mature_626_residues
MNLSNITSNVSMPNIEPDREIHSARTSTAALTPADYYAIWEKWESEAIPGTDEQRRFAVECMKDCLEKNTYHLCLRDLNL
ASLPDILPPCNELDLMGNKLTELPATLPDNLQKLNASFNQLRTLPDTLPASLLSLNVYGNELERLPESLPEGLKELDVND
NESLQLPNRLPPNLESLGIASCGLTELPTLPNSLKRLDADSNQLRTLPDTLPISLLNLSVTSNQLTQLPETLPASLSFLM
VLSNRLTKLPENLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRINPYYQGPRINWSELDNLP
PASLRNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFLHRLATTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIA
QEASATCEDRITLTHNDMQKAVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAY
QVKLLNSLQLSSVNKEMRFFGVSHVTADDLLSAETRVKTAENQDFSRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALEN
IYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDMALTHEVLSAKGASSLLDNLWMEYLISP

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 70347; Mature: 70347

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSNVSMPNIEPDREIHSARTSTAALTPADYYAIWEKWESEAIPGTDEQRRFAVE
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
CMKDCLEKNTYHLCLRDLNLASLPDILPPCNELDLMGNKLTELPATLPDNLQKLNASFNQ
HHHHHHHCCCCEEHHHHCCHHHCCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
LRTLPDTLPASLLSLNVYGNELERLPESLPEGLKELDVNDNESLQLPNRLPPNLESLGIA
HHCCHHHHHHHHHEEHHCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHCCCC
SCGLTELPTLPNSLKRLDADSNQLRTLPDTLPISLLNLSVTSNQLTQLPETLPASLSFLM
CCCCCCCCCCCHHHHHCCCCCCHHCCCCCCCCEEHEEEEECHHHHHHHHHHHHHHHHHHH
VLSNRLTKLPENLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHL
HHHHHHHHCCCCCCCCEEEECHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHH
RINPYYQGPRINWSELDNLPPASLRNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFL
CCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHH
HRLATTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRITLTHNDMQK
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCCCCCCEEEEHHHHHH
AVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAY
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QVKLLNSLQLSSVNKEMRFFGVSHVTADDLLSAETRVKTAENQDFSRWLSQWSPWKSVVQ
HHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHH
RIEPERYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDMA
HHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LTHEVLSAKGASSLLDNLWMEYLISP
HHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLSNITSNVSMPNIEPDREIHSARTSTAALTPADYYAIWEKWESEAIPGTDEQRRFAVE
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
CMKDCLEKNTYHLCLRDLNLASLPDILPPCNELDLMGNKLTELPATLPDNLQKLNASFNQ
HHHHHHHCCCCEEHHHHCCHHHCCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
LRTLPDTLPASLLSLNVYGNELERLPESLPEGLKELDVNDNESLQLPNRLPPNLESLGIA
HHCCHHHHHHHHHEEHHCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHCCCC
SCGLTELPTLPNSLKRLDADSNQLRTLPDTLPISLLNLSVTSNQLTQLPETLPASLSFLM
CCCCCCCCCCCHHHHHCCCCCCHHCCCCCCCCEEHEEEEECHHHHHHHHHHHHHHHHHHH
VLSNRLTKLPENLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHL
HHHHHHHHCCCCCCCCEEEECHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHH
RINPYYQGPRINWSELDNLPPASLRNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFL
CCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHH
HRLATTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRITLTHNDMQK
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCCCCCCEEEEHHHHHH
AVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAY
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QVKLLNSLQLSSVNKEMRFFGVSHVTADDLLSAETRVKTAENQDFSRWLSQWSPWKSVVQ
HHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHH
RIEPERYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDMA
HHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LTHEVLSAKGASSLLDNLWMEYLISP
HHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]