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The map label for this gene is iucA2 [H]

Identifier: 22127257

GI number: 22127257

Start: 3726341

End: 3727411

Strand: Direct

Name: iucA2 [H]

Synonym: y3381

Alternate gene names: 22127257

Gene position: 3726341-3727411 (Clockwise)

Preceding gene: 22127256

Following gene: 22127258

Centisome position: 80.99

GC content: 54.62

Gene sequence:

>1071_bases
ATGCACCCCTGGCAAGCCGATCACCTATTGAAACAAGACTGGTGCCAGCAATTAGTACAACAAAACGCGTTGCATGATCT
GGGCGAAGCGGGTGAACGCTGGCTACCCACCAGCTCTTCACGTTCACTGTACAGCCCGTCAAACCGCGACATGGTCAAGT
TCTCACTCAGTGTGCGCCTGACCAACTCAGTACGAACCCTGTCGGTAAAAGAGGCCAAACGCGGTATGCGCTTGGCACGT
TTGGCTCAAACGCCCCGCTGGCAAGAGCTGCAAGCGCGCTACCCGACTTTCCGTGTGATGCAGGAAGATGGTTGGGCCGG
TTTGCGTTCAGCCGATTTCACTCTTCAAGAAGAGAGTCTGTTGGTGCTACGTGACAACCTGCTATTCAGCCAACCCGATA
GCCAGACCAATGTGTTGGTCACCTTGACACAAGCCGCGCCCGATGGGGGGGACAGCCTGCTGGCCAGTGCTGTGCGTCGT
TTGGCTGCCCGTCTGAATCTGCCATTGCAACAGGCCGCTTTCTGCTGGCTGGATGCTTACTGCCAGCACGTCTTATTGCC
ACTGTTCAGCACCGAGGCTGACTACGGGCTGGTGTTGTTAGCGCATCAGCAAAATATTCTGGTGGAGATGCAGCAAGATC
TGCCTGTCGGTATGTTGTACCGCGACTGCCAAGGGAGCGGCTTTACCCAGAGCGCGCTGCCGTGGTTGGCGGAAATTGGC
GAAGCCGAAGCGGAAAATAGCTTTAGCGAACAGCAATTATTACGTTACTTCCCGTATTACCTGCTGGTGAACTCCAGCCT
CGCGGTAACGGCTGCCTTGGCTGCCGCAGGTTTCGACAGCGAGGAAAATTTGATGGTTCGTGTGCGTGACGCACTCAGCG
CCCTGCGTACTTGCGCCAAAAACACCTTATGTCTGGATTACGTACTTGATAGCCCACATTGGCACTGCAAAGGTAATTTC
TTCTGCTATCTACACGATCACAACGAAAACACCATCGTTGATCCGGCAGTGATCTACTTCGATTTCGTTAACCCTCTGCA
CCAGGGGGTGATCCATGGGGCCACACGCTAA

Upstream 100 bases:

>100_bases
TAGCCTAAAGCTAACGCTACAACACCGGCTGCAACGCTTTGCCAGCGAAAGCGCCCCACAATTACTCGCGCATTTTACCG
ATGACGTTTGGCTGCTCCCC

Downstream 100 bases:

>100_bases
GTTAATACACTCCGGTGGCAGTTTTTACTGTGAACATCTGGGAAAGGCGCTGACTCTCGGTCTGGGACTTGATGGCAGTG
CCGTACTGCACTTGCCTGGG

Product: aerobactin synthetase (subunit alpha)

Products: ADP; phosphate; aerobactin

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MHPWQADHLLKQDWCQQLVQQNALHDLGEAGERWLPTSSSRSLYSPSNRDMVKFSLSVRLTNSVRTLSVKEAKRGMRLAR
LAQTPRWQELQARYPTFRVMQEDGWAGLRSADFTLQEESLLVLRDNLLFSQPDSQTNVLVTLTQAAPDGGDSLLASAVRR
LAARLNLPLQQAAFCWLDAYCQHVLLPLFSTEADYGLVLLAHQQNILVEMQQDLPVGMLYRDCQGSGFTQSALPWLAEIG
EAEAENSFSEQQLLRYFPYYLLVNSSLAVTAALAAAGFDSEENLMVRVRDALSALRTCAKNTLCLDYVLDSPHWHCKGNF
FCYLHDHNENTIVDPAVIYFDFVNPLHQGVIHGATR

Sequences:

>Translated_356_residues
MHPWQADHLLKQDWCQQLVQQNALHDLGEAGERWLPTSSSRSLYSPSNRDMVKFSLSVRLTNSVRTLSVKEAKRGMRLAR
LAQTPRWQELQARYPTFRVMQEDGWAGLRSADFTLQEESLLVLRDNLLFSQPDSQTNVLVTLTQAAPDGGDSLLASAVRR
LAARLNLPLQQAAFCWLDAYCQHVLLPLFSTEADYGLVLLAHQQNILVEMQQDLPVGMLYRDCQGSGFTQSALPWLAEIG
EAEAENSFSEQQLLRYFPYYLLVNSSLAVTAALAAAGFDSEENLMVRVRDALSALRTCAKNTLCLDYVLDSPHWHCKGNF
FCYLHDHNENTIVDPAVIYFDFVNPLHQGVIHGATR
>Mature_356_residues
MHPWQADHLLKQDWCQQLVQQNALHDLGEAGERWLPTSSSRSLYSPSNRDMVKFSLSVRLTNSVRTLSVKEAKRGMRLAR
LAQTPRWQELQARYPTFRVMQEDGWAGLRSADFTLQEESLLVLRDNLLFSQPDSQTNVLVTLTQAAPDGGDSLLASAVRR
LAARLNLPLQQAAFCWLDAYCQHVLLPLFSTEADYGLVLLAHQQNILVEMQQDLPVGMLYRDCQGSGFTQSALPWLAEIG
EAEAENSFSEQQLLRYFPYYLLVNSSLAVTAALAAAGFDSEENLMVRVRDALSALRTCAKNTLCLDYVLDSPHWHCKGNF
FCYLHDHNENTIVDPAVIYFDFVNPLHQGVIHGATR

Specific function: Unknown

COG id: COG4264

COG function: function code Q; Siderophore synthetase component

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iucA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007310
- InterPro:   IPR022770 [H]

Pfam domain/function: PF06276 FhuF; PF04183 IucA_IucC [H]

EC number: 6.3.2.27

Molecular weight: Translated: 40171; Mature: 40171

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPWQADHLLKQDWCQQLVQQNALHDLGEAGERWLPTSSSRSLYSPSNRDMVKFSLSVRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEE
TNSVRTLSVKEAKRGMRLARLAQTPRWQELQARYPTFRVMQEDGWAGLRSADFTLQEESL
ECCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCEECCCCE
LVLRDNLLFSQPDSQTNVLVTLTQAAPDGGDSLLASAVRRLAARLNLPLQQAAFCWLDAY
EEEECCEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CQHVLLPLFSTEADYGLVLLAHQQNILVEMQQDLPVGMLYRDCQGSGFTQSALPWLAEIG
HHHHHHHHHCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHC
EAEAENSFSEQQLLRYFPYYLLVNSSLAVTAALAAAGFDSEENLMVRVRDALSALRTCAK
CHHHCCCCCHHHHHHHCCHHHEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
NTLCLDYVLDSPHWHCKGNFFCYLHDHNENTIVDPAVIYFDFVNPLHQGVIHGATR
CCEEEEEEECCCCEEECCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHPWQADHLLKQDWCQQLVQQNALHDLGEAGERWLPTSSSRSLYSPSNRDMVKFSLSVRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEE
TNSVRTLSVKEAKRGMRLARLAQTPRWQELQARYPTFRVMQEDGWAGLRSADFTLQEESL
ECCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCEECCCCE
LVLRDNLLFSQPDSQTNVLVTLTQAAPDGGDSLLASAVRRLAARLNLPLQQAAFCWLDAY
EEEECCEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CQHVLLPLFSTEADYGLVLLAHQQNILVEMQQDLPVGMLYRDCQGSGFTQSALPWLAEIG
HHHHHHHHHCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHC
EAEAENSFSEQQLLRYFPYYLLVNSSLAVTAALAAAGFDSEENLMVRVRDALSALRTCAK
CHHHCCCCCHHHHHHHCCHHHEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
NTLCLDYVLDSPHWHCKGNFFCYLHDHNENTIVDPAVIYFDFVNPLHQGVIHGATR
CCEEEEEEECCCCEEECCCEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; citrate; N6-acetyl-N6-hydroxylysine

Specific reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8003107 [H]