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The map label for this gene is frr [H]

Identifier: 22127009

GI number: 22127009

Start: 3446092

End: 3446649

Strand: Reverse

Name: frr [H]

Synonym: y3133

Alternate gene names: 22127009

Gene position: 3446649-3446092 (Counterclockwise)

Preceding gene: 22127010

Following gene: 22127007

Centisome position: 74.91

GC content: 47.49

Gene sequence:

>558_bases
GTGATTAACGAAATTAGAAAAGATGCCGAAGTGCGCATGGAAAAATGTCTGGAAGCATTCCAGAACCACATTAGTAAAAT
CCGTACGGGTCGTGCCTCTCCAAGTATCCTTGATGGCATTCAGGTTGAGTACTACGGTACGGCGACACCATTGCGCCAAT
TGGCTAACATTGTAGTAGAAGACTCCCGTACTTTAGCGCTAACAGTCTTCGACCGTAGCCTGAGTGCTGCGGTAGAGAAG
GCTATCATGACTTCAGATTTGGGGCTGAATCCATCGTCCGCCGGTACTGTTATCCGTGTTCCATTGCCAGCATTGACGGA
AGAGCGTCGTAAAGACTTGATTAAAGTCGTGCGGGCAGAAGCAGAGCAGGGGCGTGTGTCTATTCGTAACGTGCGCCGTG
ATGCTAACGATAAAGTGAAGGCATTGCTGAAAGACAAAGAAATCAGCGAAGACGAAGATCGCCGTTCACAAGACGATGTG
CAAAAGCTGACGGATGCCTATATCAAGAAAGTTGATGCTGCATTGGCGGTAAAAGAAGCTGAGTTGATGGATTTTTAA

Upstream 100 bases:

>100_bases
TCTGTCTGCCCCTTTAGCCAGCAACTGTTGGTTTGTATATTCACCGGCTATACTCAAAAGCTATGGCCAGCCAAGTAACC
AGTTTCCAAGGGTTCGCAAC

Downstream 100 bases:

>100_bases
TCTCTACTCGCATTGTATAAGCGTCGCCTTAGGCGGCGCTTTGCTTTTTTTCCGGTCATGTTTTGTCTGATCAATGTTTT
ATCTGATCAATGTCTTATCT

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVEDSRTLALTVFDRSLSAAVEK
AIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAEAEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDV
QKLTDAYIKKVDAALAVKEAELMDF

Sequences:

>Translated_185_residues
MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVEDSRTLALTVFDRSLSAAVEK
AIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAEAEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDV
QKLTDAYIKKVDAALAVKEAELMDF
>Mature_185_residues
MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVEDSRTLALTVFDRSLSAAVEK
AIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAEAEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDV
QKLTDAYIKKVDAALAVKEAELMDF

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another [H]

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family [H]

Homologues:

Organism=Homo sapiens, GI20270317, Length=174, Percent_Identity=32.183908045977, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI291042689, Length=150, Percent_Identity=32.6666666666667, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1786368, Length=185, Percent_Identity=81.0810810810811, Blast_Score=305, Evalue=9e-85,
Organism=Drosophila melanogaster, GI24661488, Length=174, Percent_Identity=28.1609195402299, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002661
- InterPro:   IPR015998 [H]

Pfam domain/function: PF01765 RRF [H]

EC number: NA

Molecular weight: Translated: 20710; Mature: 20710

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHC
DSRTLALTVFDRSLSAAVEKAIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAE
CCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
AEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDVQKLTDAYIKKVDAALAVKEA
HHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ELMDF
HHHCC
>Mature Secondary Structure
MINEIRKDAEVRMEKCLEAFQNHISKIRTGRASPSILDGIQVEYYGTATPLRQLANIVVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHC
DSRTLALTVFDRSLSAAVEKAIMTSDLGLNPSSAGTVIRVPLPALTEERRKDLIKVVRAE
CCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
AEQGRVSIRNVRRDANDKVKALLKDKEISEDEDRRSQDDVQKLTDAYIKKVDAALAVKEA
HHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ELMDF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA