Click here to switch to the map view.

The map label for this gene is moaE [H]

Identifier: 22126896

GI number: 22126896

Start: 3327697

End: 3328155

Strand: Reverse

Name: moaE [H]

Synonym: y3019

Alternate gene names: 22126896

Gene position: 3328155-3327697 (Counterclockwise)

Preceding gene: 22126897

Following gene: 22126895

Centisome position: 72.34

GC content: 54.25

Gene sequence:

>459_bases
GTGATGATGGAAAATACGCGTATCCGTGTCGGCGCAGAAGCGTTCAGTGTGGGTGATGAATACACATGGCTGTCGCAGTG
CGATGAAGACGGCGCGGTGGTGACCTTCACTGGCAAAGTCCGTAATCATAATCTGGGGGCCAGTGTCAGTGCGCTAACAC
TGGAACACTACCCCGGTATGACAGAAAAAGCGCTGACGGAGATTATTGCCGACGCACGCAGCCGTTGGTCATTGCAGCGG
GTATCGGTCATCCATCGGGTCGGGCCACTATTCCCCGGAGATGAAATTGTCTTTGTGGGTGTGACCAGCGCTCATCGCAG
TATGGCATTTGAAGCAGCAGAATTTATTATGGACTACCTGAAAACACGGGCACCATTCTGGAAGCGGGAAGCCACGGTCG
AGGGTGAGCGCTGGGTTGAATCACGGGACAGCGACCATATTGCGGCTAAACGCTGGTAA

Upstream 100 bases:

>100_bases
AGGGCAAATTACTGACGGCGGTTAACCAATCATTAGTGAGTGCTCAGCATCCACTGGCCGCAGGTGATGAAGTGGCGTTT
TTCCCGCCGGTGACCGGGGG

Downstream 100 bases:

>100_bases
TCTAGGCGCAGAACAGCATAAAAATCACGGCTAAATGTCTATTTTTACTCCTTTGTTTCCGCTATTTCTATGGTACCCTT
AAAAAGACGGTGGGCTGTCA

Product: molybdopterin guanine dinucleotide biosynthesis protein MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MMMENTRIRVGAEAFSVGDEYTWLSQCDEDGAVVTFTGKVRNHNLGASVSALTLEHYPGMTEKALTEIIADARSRWSLQR
VSVIHRVGPLFPGDEIVFVGVTSAHRSMAFEAAEFIMDYLKTRAPFWKREATVEGERWVESRDSDHIAAKRW

Sequences:

>Translated_152_residues
MMMENTRIRVGAEAFSVGDEYTWLSQCDEDGAVVTFTGKVRNHNLGASVSALTLEHYPGMTEKALTEIIADARSRWSLQR
VSVIHRVGPLFPGDEIVFVGVTSAHRSMAFEAAEFIMDYLKTRAPFWKREATVEGERWVESRDSDHIAAKRW
>Mature_152_residues
MMMENTRIRVGAEAFSVGDEYTWLSQCDEDGAVVTFTGKVRNHNLGASVSALTLEHYPGMTEKALTEIIADARSRWSLQR
VSVIHRVGPLFPGDEIVFVGVTSAHRSMAFEAAEFIMDYLKTRAPFWKREATVEGERWVESRDSDHIAAKRW

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=131, Percent_Identity=34.3511450381679, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1787003, Length=150, Percent_Identity=77.3333333333333, Blast_Score=244, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17509279, Length=107, Percent_Identity=33.6448598130841, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356259, Length=118, Percent_Identity=35.5932203389831, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 17194; Mature: 17194

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMENTRIRVGAEAFSVGDEYTWLSQCDEDGAVVTFTGKVRNHNLGASVSALTLEHYPGM
CCCCCCEEEECHHHHHCCCCCHHHHHCCCCCCEEEEECCEECCCCCCCCEEEEHHHCCCC
TEKALTEIIADARSRWSLQRVSVIHRVGPLFPGDEIVFVGVTSAHRSMAFEAAEFIMDYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
KTRAPFWKREATVEGERWVESRDSDHIAAKRW
HHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MMMENTRIRVGAEAFSVGDEYTWLSQCDEDGAVVTFTGKVRNHNLGASVSALTLEHYPGM
CCCCCCEEEECHHHHHCCCCCHHHHHCCCCCCEEEEECCEECCCCCCCCEEEEHHHCCCC
TEKALTEIIADARSRWSLQRVSVIHRVGPLFPGDEIVFVGVTSAHRSMAFEAAEFIMDYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
KTRAPFWKREATVEGERWVESRDSDHIAAKRW
HHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]