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The map label for this gene is hcr [H]

Identifier: 22126697

GI number: 22126697

Start: 3124798

End: 3125868

Strand: Direct

Name: hcr [H]

Synonym: y2820

Alternate gene names: 22126697

Gene position: 3124798-3125868 (Clockwise)

Preceding gene: 22126696

Following gene: 22126698

Centisome position: 67.92

GC content: 53.03

Gene sequence:

>1071_bases
TTGCGACGTCTTTTGCCAGAGAATGACCTGATTCATTGTGAGGCCCCAATGACCGATTTTATTCCAACCGATTCCCCTAC
CCCCTTCTGCCCTAACCGTATGCAGGTCCATTCCATCGTGCAAGAGACGCCCGATGTCTGGAGCCTACGGCTGATTAATC
ACGATTTTTACTCTTATTTGCCGGGCCAATACGCGTTGGTGAGTATTCGCAACAGTGATGAAACCTTGCGCGCCTATACC
CTCTCCTCGACACCGGGTTTAAGCCCTTTTATCCAACTCACCGTGCGCTGTTTACCTGATGGTGAAGGCTCCCGCTGGCT
GACGCAGCAGGTTAATGTCGGGGATTATCTGTGGCTTTCTGATGCTCAGGGCGAGTTTACCTGCGCCAATGCCGATGATG
ACCACTATCTGATGCTGGCGGCGGGCTGTGGCGTCACACCCGTAATATCAATGTGTCGCGCACTACTGGCTCAGCGCCCA
CAGGCCGATATTCGGGTAATTTTTAATGTCCGCACCCCTGCCGATGTCATTTTTGCCAATGAATGGCACACCTTATTGCA
GCGCTATCCACAGCAATTAAAACTCACGCTGATGGCAGAGTCAGCGGCAACGGCGGGGTTTATTGAGGGGCGAATTAATG
CCCGTATTATGCAGCAGGTCGCCCCCGACATTGCTCATCGCCGCGTGATGACTTGCGGGCCTGCGCCCTATATGGCGTGG
GTTGAACAGTATTGCCAACAACAGCAAGTGCCTGCCGATCATTTCCAGCAAGAGCAATTTCGTACCGCTGATGAGGTTAT
CGATACCAGTAATGAATTGACGATGACTATCAGCCGCCCGCTACGCAGTGTCAACGTCCCGGTTGGCACCTCCCTGCTCT
TTGCGCTGGAACAACATAAAATACCGGTTATGGCCGCCTGCCGCGCGGGTGTTTGTGGCTCATGTAAAACCCACATTTTG
CATGGCAAATACACCACCACCAGCACCATGACGCTAACGCCGGAAGAAATAGCGCAAGGTTATGTTCTGGCATGCAGTTG
CCAACTTCAGGGGGATGTCCAATTGGCGTGA

Upstream 100 bases:

>100_bases
TAGAACAGGATATGCAGGCGATTTTGGGCCATTAAGTTAATTATACCTTGCCTGGTCAATCGCCTTTCTCGCCGTTGACC
GGGCTATTATTGCACGCTGT

Downstream 100 bases:

>100_bases
TAGCGCCATTGGCCTGACGACGACCGACCTTCCCGCCCCATAAAGTGCCTATCCGCATCATCAATGGGGCATTTATCCTC
AAACACGCCATACTTTGACC

Product: HCP oxidoreductase, NADH-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRRLLPENDLIHCEAPMTDFIPTDSPTPFCPNRMQVHSIVQETPDVWSLRLINHDFYSYLPGQYALVSIRNSDETLRAYT
LSSTPGLSPFIQLTVRCLPDGEGSRWLTQQVNVGDYLWLSDAQGEFTCANADDDHYLMLAAGCGVTPVISMCRALLAQRP
QADIRVIFNVRTPADVIFANEWHTLLQRYPQQLKLTLMAESAATAGFIEGRINARIMQQVAPDIAHRRVMTCGPAPYMAW
VEQYCQQQQVPADHFQQEQFRTADEVIDTSNELTMTISRPLRSVNVPVGTSLLFALEQHKIPVMAACRAGVCGSCKTHIL
HGKYTTTSTMTLTPEEIAQGYVLACSCQLQGDVQLA

Sequences:

>Translated_356_residues
MRRLLPENDLIHCEAPMTDFIPTDSPTPFCPNRMQVHSIVQETPDVWSLRLINHDFYSYLPGQYALVSIRNSDETLRAYT
LSSTPGLSPFIQLTVRCLPDGEGSRWLTQQVNVGDYLWLSDAQGEFTCANADDDHYLMLAAGCGVTPVISMCRALLAQRP
QADIRVIFNVRTPADVIFANEWHTLLQRYPQQLKLTLMAESAATAGFIEGRINARIMQQVAPDIAHRRVMTCGPAPYMAW
VEQYCQQQQVPADHFQQEQFRTADEVIDTSNELTMTISRPLRSVNVPVGTSLLFALEQHKIPVMAACRAGVCGSCKTHIL
HGKYTTTSTMTLTPEEIAQGYVLACSCQLQGDVQLA
>Mature_356_residues
MRRLLPENDLIHCEAPMTDFIPTDSPTPFCPNRMQVHSIVQETPDVWSLRLINHDFYSYLPGQYALVSIRNSDETLRAYT
LSSTPGLSPFIQLTVRCLPDGEGSRWLTQQVNVGDYLWLSDAQGEFTCANADDDHYLMLAAGCGVTPVISMCRALLAQRP
QADIRVIFNVRTPADVIFANEWHTLLQRYPQQLKLTLMAESAATAGFIEGRINARIMQQVAPDIAHRRVMTCGPAPYMAW
VEQYCQQQQVPADHFQQEQFRTADEVIDTSNELTMTISRPLRSVNVPVGTSLLFALEQHKIPVMAACRAGVCGSCKTHIL
HGKYTTTSTMTLTPEEIAQGYVLACSCQLQGDVQLA

Specific function: NADH oxidoreductase acting in concert with HCP [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1787098, Length=331, Percent_Identity=59.5166163141994, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1787658, Length=307, Percent_Identity=26.7100977198697, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788104, Length=298, Percent_Identity=29.1946308724832, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 39766; Mature: 39766

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLLPENDLIHCEAPMTDFIPTDSPTPFCPNRMQVHSIVQETPDVWSLRLINHDFYSYL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHC
PGQYALVSIRNSDETLRAYTLSSTPGLSPFIQLTVRCLPDGEGSRWLTQQVNVGDYLWLS
CCCEEEEEEECCCCEEEEEEECCCCCCCHHHEEEEEECCCCCCCCEEEEECCCCCEEEEE
DAQGEFTCANADDDHYLMLAAGCGVTPVISMCRALLAQRPQADIRVIFNVRTPADVIFAN
CCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEC
EWHTLLQRYPQQLKLTLMAESAATAGFIEGRINARIMQQVAPDIAHRRVMTCGPAPYMAW
HHHHHHHHCCHHEEEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHCEEEECCCCHHHHH
VEQYCQQQQVPADHFQQEQFRTADEVIDTSNELTMTISRPLRSVNVPVGTSLLFALEQHK
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHCC
IPVMAACRAGVCGSCKTHILHGKYTTTSTMTLTPEEIAQGYVLACSCQLQGDVQLA
CCCEEHHCCCCCCCCCCEEEECCEECCEEEEECHHHHHCCEEEEEEEEECCCEEEC
>Mature Secondary Structure
MRRLLPENDLIHCEAPMTDFIPTDSPTPFCPNRMQVHSIVQETPDVWSLRLINHDFYSYL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHC
PGQYALVSIRNSDETLRAYTLSSTPGLSPFIQLTVRCLPDGEGSRWLTQQVNVGDYLWLS
CCCEEEEEEECCCCEEEEEEECCCCCCCHHHEEEEEECCCCCCCCEEEEECCCCCEEEEE
DAQGEFTCANADDDHYLMLAAGCGVTPVISMCRALLAQRPQADIRVIFNVRTPADVIFAN
CCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEC
EWHTLLQRYPQQLKLTLMAESAATAGFIEGRINARIMQQVAPDIAHRRVMTCGPAPYMAW
HHHHHHHHCCHHEEEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHCEEEECCCCHHHHH
VEQYCQQQQVPADHFQQEQFRTADEVIDTSNELTMTISRPLRSVNVPVGTSLLFALEQHK
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHCC
IPVMAACRAGVCGSCKTHILHGKYTTTSTMTLTPEEIAQGYVLACSCQLQGDVQLA
CCCEEHHCCCCCCCCCCEEEECCEECCEEEEECHHHHHCCEEEEEEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10651802 [H]