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The map label for this gene is pncB [H]

Identifier: 22126635

GI number: 22126635

Start: 3044056

End: 3045306

Strand: Direct

Name: pncB [H]

Synonym: y2757

Alternate gene names: 22126635

Gene position: 3044056-3045306 (Clockwise)

Preceding gene: 22126633

Following gene: 22126636

Centisome position: 66.16

GC content: 47.48

Gene sequence:

>1251_bases
TTGCCGACTGTGGAAAATGCTCCTACGAGGATGCTGTATAGCGCCATGACTCAAGACGCCTCACCGATTTTGACTTCATT
GCTTGATACGGACGCATATAAGCTTCATATGCAACAAGCCGTATTTCATCATTATCGTCACATTACTGTTGCCGCCGAAT
TCCGCTGCCGTAGTGATGAGCTGCTGGGGGTGTATGCTGATGAAATCCGCCACCAGGTAACCCTGATGGGTCAATTAGCA
CTGACATCTGATGAGTTTATTTACCTCTCCAGTCTCCCCTTCTTCCAGGATGATTATCTGCATTGGTTGCGCGATTTTCG
TTTTAAACCAGAGCAAGTCTCCGTCGCTGTTCATGACGGTAAATTAGATATTCGCATTGCCGGTTTATGGTGTGAGGTGA
TCATGTGGGAAGTGCCTTTGCTGGCAGTGATCAGCGAAATCGTTCACCGCCGCCGCTCTACCCAAGTGACAACGGATCAA
GCGGTTCAACAACTGCGCACAAAACTTGAGCAATTCAATGCCCTCAGTGCGGATATCGATATTACTCACTTTAAATTGAT
GGATTTCGGTACCCGCCGCCGATTCTCTCGCGAGATACAGCACACCGTTGTCAGCACGTTAAAAGATGAGTTCCCTTATC
TGGTCGGCACCAGCAACTACGACTTAGCCCGCACATTAGCCTTAGCGCCCGTCGGGACTCAAGCCCATGAGTGGTTTCAG
GCTCACCAACAAATTAGCCCAACATTGGCAAACAGCCAGCGTGTAGCACTGCAAGTCTGGCTGGATGAATACCCCAATCA
ACTGGGCATCGCACTAACTGATTGCATTACTATGGATGCTTTCCTACGCGATTTTGATCTGGCTTTCGCCAACCGCTATC
AAGGCCTACGCCATGACTCTGGTGACCCGATCGAGTGGGGGGAGAAGGCTATCGCGCATTATGAAAAATTGGGTATTGAC
CCAATGAAAAAGGTATTGGTGTTTTCAGATAATCTAGATCTGGAGAAAGCATTATTCCTCTACCGTCACTTTTATCAGCG
CATTAAGTTGGTGTTTGGTATCGGTACCCGTTTGACCTGCGATATACCAGATGTTAAGCCATTGAATATTGTTATTAAAC
TGGTTGAATGTAACGATAAACCGGTGGCTAAGCTCTCAGATAGCCCGGGTAAGACTATTTGTCAGGACCCCGCATTCGTT
GATCAATTACGTAAAGCCTTTGCGCTACCGTTAGTCAAGAAAGCCAGTTAA

Upstream 100 bases:

>100_bases
GACGATGGCACATTAGTCTTAGACTTCTGATTAGCATTTATGGTGTGATGAGGCTTCAATAACATGATAATACCGGTATA
CTCCTGCAACTTTATAGATT

Downstream 100 bases:

>100_bases
TCCCCCCGTTGCCGGGTAGCGTATGTTTACCCGGTAACCCCAACACTGATATTTTTTAGCCTCTCTGTTCTTCCACAATT
AAATTTTCTACTATTACTAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MPTVENAPTRMLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLA
LTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQ
AVQQLRTKLEQFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQ
AHQQISPTLANSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGID
PMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFV
DQLRKAFALPLVKKAS

Sequences:

>Translated_416_residues
MPTVENAPTRMLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLA
LTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQ
AVQQLRTKLEQFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQ
AHQQISPTLANSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGID
PMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFV
DQLRKAFALPLVKKAS
>Mature_415_residues
PTVENAPTRMLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLAL
TSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQA
VQQLRTKLEQFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQA
HQQISPTLANSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDP
MKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVD
QLRKAFALPLVKKAS

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Escherichia coli, GI1787162, Length=401, Percent_Identity=73.5660847880299, Blast_Score=613, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6324783, Length=425, Percent_Identity=31.5294117647059, Blast_Score=200, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 47685; Mature: 47554

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVENAPTRMLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDE
CCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCC
LLGVYADEIRHQVTLMGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDG
HHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECC
KLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADID
EEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCE
ITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQ
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHEECCCCCHHHHHHH
AHQQISPTLANSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDS
HHHHCCCHHCCCCEEEEEEEHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GDPIEWGEKAIAHYEKLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTC
CCCHHHHHHHHHHHHHHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
DIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
CCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
PTVENAPTRMLYSAMTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDE
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCC
LLGVYADEIRHQVTLMGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDG
HHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECC
KLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADID
EEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCE
ITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQ
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHEECCCCCHHHHHHH
AHQQISPTLANSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDS
HHHHCCCHHCCCCEEEEEEEHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GDPIEWGEKAIAHYEKLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTC
CCCHHHHHHHHHHHHHHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
DIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
CCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA