Click here to switch to the map view.

The map label for this gene is moeB [H]

Identifier: 22126553

GI number: 22126553

Start: 2951524

End: 2952324

Strand: Direct

Name: moeB [H]

Synonym: y2674

Alternate gene names: 22126553

Gene position: 2951524-2952324 (Clockwise)

Preceding gene: 22126552

Following gene: 22126554

Centisome position: 64.15

GC content: 49.69

Gene sequence:

>801_bases
TTGCCATTCATCACCCTGTCGGAGGTTGATATGTTGCCGGAACTTTCAGATGTTGAGGCCCTGCGCTATAACCGGCAAAT
CACATTACGCGGTTTTGATTTTGACGGCCAAGAGAAACTGAAAGCGGCCAAAGTACTTATCGTTGGGTTAGGTGGCCTCG
GCTGTGCAGCGGCGCAATATCTGGCTGCCGCAGGTGTCGGGCACCTCACCCTGCTCGATTTCGATACCGTAGCCCTTTCC
AATCTACAGCGTCAGATACTGCATCGCGATAGCCGTATCGGTATGACGAAAGTGGCCTCGGCGGCGCAGACATTATCAGA
AATCAACCCGCATCTGGCGCTGAATACCCTTGATAAACAGTTAGATGATGAGCAACTCCTTAGCCTTATTGCTGAACATC
AGTTAGTGTTGGATTGTACCGATAATCTCAGCACCCGCGAGCAACTCAATCGGCTGTGCCATACGCTAGGCAAACCACTG
GTCTCTGGTGCAGCAATCCGTATGGAGGGGCAAGTCAGCGTCTTCACTTATCAAGATAATCAACCTTGTTACCGCTGTCT
AAGCCGGTTATTTGGTGATACTGCCCTAACCTGTGTCGAGGCCGGCGTAATGGCTCCCTTAGTGGGTATTATCGGTAATT
TACAGGCAATGGAAGCCATAAAGCTGTTGGCAAATTATGGTCAGCTGGTATCAGGGCGTTTATTAATGTATGACGCGATG
ACTGCGGAATTTCGCAGTATAACGCTGGCAAAAGATCCTTTGTGCGAAGTCTGCCAGAGTGATAGAAGATCGCCACTATA
A

Upstream 100 bases:

>100_bases
AACTGTTTTATCGTGCTTGAACGGGAACGCGGTTCGGTAGCCGTGGGGGAATCCGTAGAAATAGAGTTGTTTAATGAATT
GTTAGGAGGTAATCGACCGT

Downstream 100 bases:

>100_bases
TGAATACATTAAACTGGGGCAGAAATACTCCCCAGTTGAATAAAAAAATCAGATGGTGTCTTTTGAGACTGTAAACAATA
TTGTGTAATTGCCTGTTTTT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MPFITLSEVDMLPELSDVEALRYNRQITLRGFDFDGQEKLKAAKVLIVGLGGLGCAAAQYLAAAGVGHLTLLDFDTVALS
NLQRQILHRDSRIGMTKVASAAQTLSEINPHLALNTLDKQLDDEQLLSLIAEHQLVLDCTDNLSTREQLNRLCHTLGKPL
VSGAAIRMEGQVSVFTYQDNQPCYRCLSRLFGDTALTCVEAGVMAPLVGIIGNLQAMEAIKLLANYGQLVSGRLLMYDAM
TAEFRSITLAKDPLCEVCQSDRRSPL

Sequences:

>Translated_266_residues
MPFITLSEVDMLPELSDVEALRYNRQITLRGFDFDGQEKLKAAKVLIVGLGGLGCAAAQYLAAAGVGHLTLLDFDTVALS
NLQRQILHRDSRIGMTKVASAAQTLSEINPHLALNTLDKQLDDEQLLSLIAEHQLVLDCTDNLSTREQLNRLCHTLGKPL
VSGAAIRMEGQVSVFTYQDNQPCYRCLSRLFGDTALTCVEAGVMAPLVGIIGNLQAMEAIKLLANYGQLVSGRLLMYDAM
TAEFRSITLAKDPLCEVCQSDRRSPL
>Mature_265_residues
PFITLSEVDMLPELSDVEALRYNRQITLRGFDFDGQEKLKAAKVLIVGLGGLGCAAAQYLAAAGVGHLTLLDFDTVALSN
LQRQILHRDSRIGMTKVASAAQTLSEINPHLALNTLDKQLDDEQLLSLIAEHQLVLDCTDNLSTREQLNRLCHTLGKPLV
SGAAIRMEGQVSVFTYQDNQPCYRCLSRLFGDTALTCVEAGVMAPLVGIIGNLQAMEAIKLLANYGQLVSGRLLMYDAMT
AEFRSITLAKDPLCEVCQSDRRSPL

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=244, Percent_Identity=42.2131147540984, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI4885649, Length=158, Percent_Identity=28.4810126582279, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23510338, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI23510340, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI38327032, Length=240, Percent_Identity=25.8333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI13376212, Length=240, Percent_Identity=25.8333333333333, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI225543285, Length=116, Percent_Identity=33.6206896551724, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI4885585, Length=158, Percent_Identity=28.4810126582279, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI225543288, Length=116, Percent_Identity=33.6206896551724, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=69.2307692307692, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI87082356, Length=252, Percent_Identity=42.8571428571429, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789177, Length=121, Percent_Identity=29.7520661157025, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17540406, Length=247, Percent_Identity=40.8906882591093, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=156, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86565433, Length=178, Percent_Identity=28.0898876404494, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86565431, Length=178, Percent_Identity=28.0898876404494, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=212, Percent_Identity=39.1509433962264, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322639, Length=165, Percent_Identity=29.6969696969697, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=158, Percent_Identity=30.379746835443, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320598, Length=166, Percent_Identity=24.0963855421687, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582879, Length=250, Percent_Identity=45.6, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24660640, Length=154, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641311, Length=261, Percent_Identity=29.8850574712644, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29066; Mature: 28935

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFITLSEVDMLPELSDVEALRYNRQITLRGFDFDGQEKLKAAKVLIVGLGGLGCAAAQY
CCEEECHHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHEEEEECCCHHHHHHHH
LAAAGVGHLTLLDFDTVALSNLQRQILHRDSRIGMTKVASAAQTLSEINPHLALNTLDKQ
HHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LDDEQLLSLIAEHQLVLDCTDNLSTREQLNRLCHTLGKPLVSGAAIRMEGQVSVFTYQDN
CCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCHHHCCCEEEEECCEEEEEEECC
QPCYRCLSRLFGDTALTCVEAGVMAPLVGIIGNLQAMEAIKLLANYGQLVSGRLLMYDAM
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCEEHHHHHH
TAEFRSITLAKDPLCEVCQSDRRSPL
HHHHHHEECCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
PFITLSEVDMLPELSDVEALRYNRQITLRGFDFDGQEKLKAAKVLIVGLGGLGCAAAQY
CEEECHHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHEEEEECCCHHHHHHHH
LAAAGVGHLTLLDFDTVALSNLQRQILHRDSRIGMTKVASAAQTLSEINPHLALNTLDKQ
HHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LDDEQLLSLIAEHQLVLDCTDNLSTREQLNRLCHTLGKPLVSGAAIRMEGQVSVFTYQDN
CCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCHHHCCCEEEEECCEEEEEEECC
QPCYRCLSRLFGDTALTCVEAGVMAPLVGIIGNLQAMEAIKLLANYGQLVSGRLLMYDAM
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCEEHHHHHH
TAEFRSITLAKDPLCEVCQSDRRSPL
HHHHHHEECCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]