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The map label for this gene is adhC [H]

Identifier: 22126546

GI number: 22126546

Start: 2941574

End: 2942713

Strand: Direct

Name: adhC [H]

Synonym: y2667

Alternate gene names: 22126546

Gene position: 2941574-2942713 (Clockwise)

Preceding gene: 22126545

Following gene: 22126547

Centisome position: 63.94

GC content: 51.49

Gene sequence:

>1140_bases
ATGGAGATGATTAAAACCCGCGCCGCTGTCGCATGGGGGCCAAACCAGCCACTGTCCGTTGAAGAAGTTGATTTGATGCC
ACCACAGAAAGGCGAAGTGTTAGTGCGGATTGTCGCCAGTGGCGTTTGTCACACTGACGCTTATACCCTTTCGGGGGCCG
ATCCTGAAGGCGTATTCCCGACCATTTTAGGTCATGAAGGCGGTGGAATTGTTGAAGCCATTGGCGAAGGTGTCACCAGT
GTTGCCGTAGTGGACCACGTTATTCCGCTGTACACACCAGAGTGTGGCGAGTGCAAGTACTGCCGCTCCGGTAAAACCAA
CCTGTGCCAGGCAATCCGCAGCACTCAGGGTAAAGGTTTGATGCCCGATGGTACCACCCGCTTCTCTAAAAATGGTCAAC
CCATCTTCCACTACATGGGGACGTCAACCTTCTCCGAACTGACCGTTGTACCGGAAATATCACTCGCGAAAATCAATAAA
GAAGCCCCGTTGGAAGAAGTATGCCTGCTGGGCTGCGGCGTCACCACTGGGATGGGTGCGGTGATGAATACCGCAAAAGT
TAAACCAGGTGATACCGTCGCAATCTTCGGCCTTGGCGGTATCGGTTTATCGGCGGTGATTGGTGCACAGATGGCGGGGG
CGAGCCGAATTATTGGGATCGATCTCAATACCAGCAAATTCGAGCTGGCCCGCAAATTGGGCGCGACAGACCTGATCAAT
CCGAAAGACTATGATAAACCTATCCAGGAAGTGATCGTTGAACTGACCGACGGCGGTGTAGATTTCTCATTTGAATGCAT
TGGTAACGTCAATGTCATGCGTTCAGCATTAGAGTGCTGCCATAAAGGTTGGGGAGAGTCGGTGATTATTGGTGTCGCCG
GTGCCGGTGAAGAAATTTCAACCCGCCCGTTCCAATTGGTTACGGGCCGCGTATGGCGGGGTTCTGCATTTGGTGGCGTC
AAAGGCCGCTCAGAATTGCCGGGCATTGTGCAGCAATATTTGGACGGTAAATTCGCGTTGAACGACTTCATTACCCACAC
AATGGCGCTGGATCAAATCAACGAAGCCTTTGATTTAATGCACGAGGGTAAATCTATCCGCAGTGTGATCCATTTTAATC
ACTCTTCCGAAAGCAAATAA

Upstream 100 bases:

>100_bases
TGACTGGGGTGAGCAAGGACAGTTAACCCCCCCAGCACCTTGAAGGGCGACGGGTAGATTTATATAACACTCATTACACT
GAAGCTATAGGAGCAACACC

Downstream 100 bases:

>100_bases
AGCAAGGAGGCAGACAAAACGTGAATACGTCACTTGAACTTCTCGAAGAGCATCGGATGTTTGGCTGCTGGCAACAGCGC
TACCGCCATGCTGCCAGCAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFPTILGHEGGGIVEAIGEGVTS
VAVVDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGLMPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINK
EAPLEEVCLLGCGVTTGMGAVMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEISTRPFQLVTGRVWRGSAFGGV
KGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLMHEGKSIRSVIHFNHSSESK

Sequences:

>Translated_379_residues
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFPTILGHEGGGIVEAIGEGVTS
VAVVDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGLMPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINK
EAPLEEVCLLGCGVTTGMGAVMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEISTRPFQLVTGRVWRGSAFGGV
KGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLMHEGKSIRSVIHFNHSSESK
>Mature_379_residues
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFPTILGHEGGGIVEAIGEGVTS
VAVVDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGLMPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINK
EAPLEEVCLLGCGVTTGMGAVMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEISTRPFQLVTGRVWRGSAFGGV
KGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLMHEGKSIRSVIHFNHSSESK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=63.6856368563686, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=51.2129380053908, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=51.2, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=49.5956873315364, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=49.597855227882, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=50.1347708894879, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=50, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=48.5094850948509, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=48.7603305785124, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=70.4607046070461, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=26.5789473684211, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=25.4794520547945, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=25.1412429378531, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081918, Length=354, Percent_Identity=29.6610169491525, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=26.6423357664234, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788075, Length=369, Percent_Identity=24.6612466124661, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=374, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI226510992, Length=351, Percent_Identity=21.3675213675214, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=58.6666666666667, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=58.3554376657825, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=58.600583090379, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17562584, Length=369, Percent_Identity=29.2682926829268, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=369, Percent_Identity=25.4742547425474, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=365, Percent_Identity=28.2191780821918, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=380, Percent_Identity=25.7894736842105, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=58.4905660377358, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=31.0469314079422, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=359, Percent_Identity=28.4122562674095, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=377, Percent_Identity=28.3819628647215, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=28.2958199356913, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=300, Percent_Identity=28, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=365, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=25.9668508287293, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=62.4664879356568, Blast_Score=505, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=26.647564469914, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737897, Length=271, Percent_Identity=26.9372693726937, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40260; Mature: 40260

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFP
CCCHHHCEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCCC
TILGHEGGGIVEAIGEGVTSVAVVDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGL
EEECCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
MPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINKEAPLEEVCLLGCGVTTGMGA
CCCCCCCCCCCCCEEEEECCCCCHHHEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHH
VMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
HHHCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCC
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEIS
CCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
TRPFQLVTGRVWRGSAFGGVKGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLM
CCCEEEEECEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HEGKSIRSVIHFNHSSESK
HCCHHHHHHEEECCCCCCC
>Mature Secondary Structure
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFP
CCCHHHCEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCCC
TILGHEGGGIVEAIGEGVTSVAVVDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGL
EEECCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
MPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINKEAPLEEVCLLGCGVTTGMGA
CCCCCCCCCCCCCEEEEECCCCCHHHEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHH
VMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
HHHCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCC
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEIS
CCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
TRPFQLVTGRVWRGSAFGGVKGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLM
CCCEEEEECEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HEGKSIRSVIHFNHSSESK
HCCHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]