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The map label for this gene is folE [H]

Identifier: 22126543

GI number: 22126543

Start: 2938298

End: 2939014

Strand: Reverse

Name: folE [H]

Synonym: y2664

Alternate gene names: 22126543

Gene position: 2939014-2938298 (Counterclockwise)

Preceding gene: 22126544

Following gene: 22126542

Centisome position: 63.88

GC content: 45.61

Gene sequence:

>717_bases
GTGACCCGCATCATGCTTGTCTTATCTGGATGCGTAAGCCTGTTGGAGAAAAGAATGTCATCGCTAAGTAAAGAAGCTGA
GTTGGTTCATCAAGCGCTGCTGGCCCGTGGTCTTGAAACCCCTTTACGTAAACCAGAATTAGATGCCGAGACGCGCAAAA
CTCGGATTCAGGCCCATATGACAGAAGTCATGCATTTGCTGAATCTTGATTTAACCGACGATAGTCTGGCTGATACACCA
AGACGCATTGCGAAGATGTATGTTGATGAGATTTTCTCCGGATTGGATTACGAAAATTTCCCTAAAATCACACTGATTCA
AAATAAAATGAAAGTTGATGAAATGGTAACGGTACGGGATATCACTCTGACCAGCACCTGCGAACATCATTTTGTGACGA
TTGATGGGAAAGCCACCGTCGCTTATATTCCGAAAGACAGTGTCATTGGTTTGTCGAAAATCAACCGTATCGTGCAGTTT
TTTGCGCAGCGTCCGCAAGTGCAGGAACGATTAACACAGCAGATCTTGCTCGCATTACAAACCCTGTTGGGTACCAATAA
TGTCGCAGTTTCTATTGATGCAGTTCATTATTGCGTTAAAGCACGTGGTATCCGTGATGCGACCAGCGCGACGACCACCA
CATCATTAGGCGGGTTATTTAAATCCAGTCAGAATACGCGTCAGGAATTTCTGCGTGCGGTTCGTCACCACGGCTGA

Upstream 100 bases:

>100_bases
ACGATGCTCAGTATTGTTCGCAATGAATAACCGGTCGAAATGAAGAACAATCACTGGATAATCATTTCGCTCTCAATTAG
AGTGAGAGCGAAATTCGGGT

Downstream 100 bases:

>100_bases
TTGGCTTTTTGCCAGAGGGAGGGCCTGTAGGCCCTCGAATACAGGATGTCGAGTATGCGTCAACGCATCGCAACGTTAGA
CAGTGCGCGGGGGCTGGCCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTRIMLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTP
RRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQF
FAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG

Sequences:

>Translated_238_residues
MTRIMLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTP
RRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQF
FAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
>Mature_237_residues
TRIMLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPR
RIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFF
AQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=123, Percent_Identity=44.7154471544715, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4503949, Length=123, Percent_Identity=44.7154471544715, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI66932970, Length=82, Percent_Identity=48.780487804878, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI66932972, Length=82, Percent_Identity=48.780487804878, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1788476, Length=222, Percent_Identity=89.1891891891892, Blast_Score=389, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17560486, Length=189, Percent_Identity=37.5661375661376, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=40.1098901098901, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656796, Length=122, Percent_Identity=45.0819672131148, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656791, Length=122, Percent_Identity=45.0819672131148, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656782, Length=122, Percent_Identity=45.0819672131148, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26746; Mature: 26615

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIMLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
TEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRD
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHH
ITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQ
EEEECCCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
HHHCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRIMLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
TEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRD
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHH
ITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQ
EEEECCCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
HHHCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA