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The map label for this gene is gnd [H]

Identifier: 22126509

GI number: 22126509

Start: 2891897

End: 2893357

Strand: Reverse

Name: gnd [H]

Synonym: y2629

Alternate gene names: 22126509

Gene position: 2893357-2891897 (Counterclockwise)

Preceding gene: 22126510

Following gene: 22126499

Centisome position: 62.89

GC content: 47.57

Gene sequence:

>1461_bases
TTGGCCTTAAGGCTGGTAACAGGTGTCATCCTTCAGACAGGAGTTTTTTTAATGTCCAAACAACAGATCGGCGTTGTCGG
TATGGCGGTGATGGGCCGTAACCTGGCGCTCAACATCGAAAGCCGTGGCTATTCCGTTTCTATTTTTAACCGTTCATCAG
ACAAAACCGACGAAGTGGTTGCCGAGAATCCAGGTAAGAATCTGGTGCCGAGTTATACCGTTGAAGAGTTTGTTGATTCA
CTGGAAAAACCGCGCCGTATCCTGCTGATGGTGAAAGCGGGTGAAGCAACAGATAAAACGATCGCTTCACTGACGCCGCA
TCTTGATAAAGGCGATATTCTGATTGATGGTGGCAATACTTATTACAAAGACACCATTCGTCGTAACCGTGAACTTTCTG
CACAAGGCTTTAACTTTATCGGTACCGGCGTGTCTGGTGGTGAAGAGGGTGCATTGAAAGGCCCTTCTATCATGCCGGGT
GGCCAGAAAGAAGCCTACGAATTGGTTGCCCCGATCCTTGAGAAAATTGCGGCCCGTGCTGATGATGGTGACGCCTGCGT
TGCCTATATCGGCGCTGACGGTGCTGGCCATTACGTTAAAATGGTTCACAACGGTATCGAATACGGTGATATGCAATTGA
TCGCCGAAGCCTATTCACTGCTGAAACAGTCTCTGGGTCTGAGCAATGAAGAGCTGGCCAGTACTTTTGCTGAGTGGAAC
AAAGGCGAACTGAACAGCTACCTGATTGATATCACCAAAGACATCTTCACCAAGAAAGACGAAGACGGTAACTATCTGGT
TGATGTGATCCTGGACGAAGCTGCCAACAAAGGCACCGGTAAATGGACCAGCCAAAGTTCTCTGGACTTGGGTGAGCCGT
TAACACTGATCACTGAATCTGTGTTTGCCCGTTACTTGTCTTCTCTGAAAGATCAACGTGTTGCTGCCTCTAAAGTGTTG
ACTGGCCCTAAAGTTCAGCCTTTCACTGGTGATAAAGCCGAGTTTATCGAAAAAATTCGTCGCGCGCTGTATCTGGGTAA
AATCGTTTCTTACGCACAAGGTTTCTCTCAACTGAAAGCGGCATCTAACGAGAATAACTGGGATCTGAATTACGGTGAAA
TCGCGAAGATTTTCCGTGCTGGCTGTATTATTCGTGCTCAGTTCCTACAAAAAATTACTGATGCTTATGCAGAAAACGCA
GATATCGCTAACTTGCTGCTGGCACCGTACTTCAAGCAAATTGCTGATGAATACCAGCAAGCGCTGCGTGATGTGGTGTC
TTATGCGGTACAAAACGGTATCCCAACGCCAACATTCTCTGCTGCGATTAACTATTACGACAGCTACCGTTCAGCCGTGC
TGCCTGCTAACTTGATCCAGGCACAGCGCGACTATTTCGGTGCGCATACGTATAAGCGGACAGATAAAGAAGGTGTATTC
CACACTGAGTGGATGGCGTAA

Upstream 100 bases:

>100_bases
CGTGTGCGCACAGCAACTAGTCAGTTGTGCTATCTATCGCACCAATCACTACCCAGCTGACATAATCCTGAGTTAACATG
TTTCCCACATCAAAAACCTG

Downstream 100 bases:

>100_bases
TCCCTTTAACGGCGACTGTGCTTTGCCATTCTGGGATCGCGCAGTGCTCGGGTGCCTCACGTATTGCGTGTACGCTCCGG
GCGCGGTTGACGTCATAGAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MALRLVTGVILQTGVFLMSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSSDKTDEVVAENPGKNLVPSYTVEEFVDS
LEKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNTYYKDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPG
GQKEAYELVAPILEKIAARADDGDACVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQSLGLSNEELASTFAEWN
KGELNSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSSLDLGEPLTLITESVFARYLSSLKDQRVAASKVL
TGPKVQPFTGDKAEFIEKIRRALYLGKIVSYAQGFSQLKAASNENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENA
DIANLLLAPYFKQIADEYQQALRDVVSYAVQNGIPTPTFSAAINYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVF
HTEWMA

Sequences:

>Translated_486_residues
MALRLVTGVILQTGVFLMSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSSDKTDEVVAENPGKNLVPSYTVEEFVDS
LEKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNTYYKDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPG
GQKEAYELVAPILEKIAARADDGDACVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQSLGLSNEELASTFAEWN
KGELNSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSSLDLGEPLTLITESVFARYLSSLKDQRVAASKVL
TGPKVQPFTGDKAEFIEKIRRALYLGKIVSYAQGFSQLKAASNENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENA
DIANLLLAPYFKQIADEYQQALRDVVSYAVQNGIPTPTFSAAINYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVF
HTEWMA
>Mature_485_residues
ALRLVTGVILQTGVFLMSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSSDKTDEVVAENPGKNLVPSYTVEEFVDSL
EKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNTYYKDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPGG
QKEAYELVAPILEKIAARADDGDACVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQSLGLSNEELASTFAEWNK
GELNSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSSLDLGEPLTLITESVFARYLSSLKDQRVAASKVLT
GPKVQPFTGDKAEFIEKIRRALYLGKIVSYAQGFSQLKAASNENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENAD
IANLLLAPYFKQIADEYQQALRDVVSYAVQNGIPTPTFSAAINYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVFH
TEWMA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=469, Percent_Identity=54.1577825159915, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=87.6068376068376, Blast_Score=852, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=50.7430997876858, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=50.1089324618736, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=49.7787610619469, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=51.4893617021277, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53387; Mature: 53256

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRLVTGVILQTGVFLMSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSSDKTDEVV
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCEEEEEEECCCCCCCHHH
AENPGKNLVPSYTVEEFVDSLEKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNT
HCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEECCCC
YYKDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEKIAARA
HHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
DDGDACVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQSLGLSNEELASTFAEWN
CCCCEEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
KGELNSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSSLDLGEPLTLITES
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
VFARYLSSLKDQRVAASKVLTGPKVQPFTGDKAEFIEKIRRALYLGKIVSYAQGFSQLKA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASNENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENADIANLLLAPYFKQIADEYQQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALRDVVSYAVQNGIPTPTFSAAINYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVF
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCE
HTEWMA
ECCCCC
>Mature Secondary Structure 
ALRLVTGVILQTGVFLMSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSSDKTDEVV
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCEEEEEEECCCCCCCHHH
AENPGKNLVPSYTVEEFVDSLEKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNT
HCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEECCCC
YYKDTIRRNRELSAQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILEKIAARA
HHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
DDGDACVAYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQSLGLSNEELASTFAEWN
CCCCEEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
KGELNSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSSLDLGEPLTLITES
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
VFARYLSSLKDQRVAASKVLTGPKVQPFTGDKAEFIEKIRRALYLGKIVSYAQGFSQLKA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASNENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENADIANLLLAPYFKQIADEYQQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALRDVVSYAVQNGIPTPTFSAAINYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKEGVF
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCE
HTEWMA
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]