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The map label for this gene is yegE [H]

Identifier: 22126440

GI number: 22126440

Start: 2820902

End: 2822257

Strand: Direct

Name: yegE [H]

Synonym: y2559

Alternate gene names: 22126440

Gene position: 2820902-2822257 (Clockwise)

Preceding gene: 22126439

Following gene: 22126441

Centisome position: 61.31

GC content: 48.6

Gene sequence:

>1356_bases
TTGGGTTTCACCAAGATTGTCCGCGACTTGACTGAACGCCACCAACGTGAAGAAACATTGCGTATCAGCGAAGAACGCTT
TCGCCTGATGGTTGATTCTGTTGAAGATTATGCCATTTTAATGCTAGACCCTTGGGGTCGGGTTAATACCTGGAATCACG
GTGCACAACACAAGATTGGCTATGCCAGTAACGAGATTATCGGCCAGCATTTCGGCTGCCTCTTCTTGCCGGAAGACCTT
GTTGCAGGGCTACCAGGAAAACTGCTGAAAACAGCGGCGTCAGCGAGCCGTATAGAGTACGAAGGTTGGTTGGTTCGTAA
AGATATTACCCGCTATTGGGCGCTTACCGTGATTACAGCGATACATGACCATAACGGTAAACTGTTGGGTTATACCAAAC
TCATCCGTGATATTAGTGAGCGAAAACAACGCGAAGATGCCCTGCGCGCCAGTGAAGCTGCCCGCTATGAAGAGCGCGAA
CAGTTACATCAAGTTCTGTCATCCATTCCTGATGGGATTATCTCTCTCAATAGTGAAGGCCGGGTGGTATTAATGAACCC
GAAAGCTGAAGAGATGACGGGCTGTAGGCAGAATGAATCCTGTGGTTTACCGATTGAAGAGGTCTTTATTTTGTGGTCTC
CACTACAGGATAAAAATCAATTAGAGGCCTTCAGTCAATGCCTGGCTGAAGGACGACAGACCCTATTACCAGAAGGCCAT
TATCTGGTATCTCGCTGGGGAGAACGCCAAGAAATACGCTGTTCAGCTTCACCAATACGTGATCGTGACAATATTGTTAC
TGGCGCCGTCGTGGTATTCCAAGATGTCACCCGTGCACGCCATGAACAGCGGGCGCTGCAATACCAGGCTAGCCATGACA
TGCTCACCGGGTTAATTAACCGCCGACGATTGGAAGAGCGATTGACACTAGCGATTAATCAATTAGCTCATGACGGGCAA
CATATACTTTGCTATGTCGATTTAGACTATTTCAAAGATGTGAATGATAATGCGGGTCACGAAGCGGGGGATATGGTGCT
GAGAATGGTCGCACAAACCATGCAACAAGCGGTGCGAGAAAACGATATTGTTGCCCGTTTAGGCGGGGATGAATTTGCGA
TTGTGCTCTTTAATTGCCCCAGTAAATCTGCGGCAGAAATACTGGAACAGGTCGTGGCGGATATTGCCGCCATCCAGTTT
CATTGGCACGGACAATCTTATGTCCTTACTGCCAGTCTGGGGGCAATACCATTGACCCAACAAACTGAATCCGCTTCGCA
AGCGATGCGTTTGGCCGATATTGCCTGCTACAAGGCCAAACATGCTGGCCGCAACCAATTGTCACTCACCTCTTGA

Upstream 100 bases:

>100_bases
AGGTAATTTCCAGACTGAAGGGTGGCATGTCCGTAAGAATAATATCCGTTATTGGGCCAGTGTCGCCATTAGCCCAATAC
ACGATGACCAAGGAAACTTA

Downstream 100 bases:

>100_bases
GGTATATTGCGGGTGGCTATCATGTCACCTGCAATGTTTTTATGATTGGCCCATCCCTCTGCTCAGCATGAATACTGATG
CGGCCCCAAAGTGAATTAGC

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIGYASNEIIGQHFGCLFLPEDL
VAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEERE
QLHQVLSSIPDGIISLNSEGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPEGH
YLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLINRRRLEERLTLAINQLAHDGQ
HILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQF
HWHGQSYVLTASLGAIPLTQQTESASQAMRLADIACYKAKHAGRNQLSLTS

Sequences:

>Translated_451_residues
MGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIGYASNEIIGQHFGCLFLPEDL
VAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEERE
QLHQVLSSIPDGIISLNSEGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPEGH
YLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLINRRRLEERLTLAINQLAHDGQ
HILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQF
HWHGQSYVLTASLGAIPLTQQTESASQAMRLADIACYKAKHAGRNQLSLTS
>Mature_450_residues
GFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIGYASNEIIGQHFGCLFLPEDLV
AGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEEREQ
LHQVLSSIPDGIISLNSEGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPEGHY
LVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLINRRRLEERLTLAINQLAHDGQH
ILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQFH
WHGQSYVLTASLGAIPLTQQTESASQAMRLADIACYKAKHAGRNQLSLTS

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=326, Percent_Identity=34.6625766871166, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1786584, Length=177, Percent_Identity=32.7683615819209, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081881, Length=319, Percent_Identity=26.0188087774295, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787541, Length=289, Percent_Identity=30.4498269896194, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87081977, Length=167, Percent_Identity=34.1317365269461, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082007, Length=170, Percent_Identity=35.8823529411765, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787262, Length=233, Percent_Identity=26.1802575107296, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693134, Length=187, Percent_Identity=31.0160427807487, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1787802, Length=165, Percent_Identity=32.7272727272727, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081974, Length=100, Percent_Identity=36, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788956, Length=153, Percent_Identity=34.640522875817, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787056, Length=161, Percent_Identity=31.6770186335404, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788085, Length=162, Percent_Identity=31.4814814814815, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787816, Length=163, Percent_Identity=30.0613496932515, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 51027; Mature: 50895

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC
YASNEIIGQHFGCLFLPEDLVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITA
CCCHHHHHHHCCEEEECHHHHCCCCHHHHHHHHHHCCEEECCEEEHHHHHHHHHHHHHHH
IHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNSEG
HCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
RVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPEGH
EEEEECCCHHHHHCCCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHCHHHCCCCCC
YLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLIN
HHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRRLEERLTLAINQLAHDGQHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRE
HHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHC
NDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQFHWHGQSYVLTASLGAIPLTQ
CCEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCC
QTESASQAMRLADIACYKAKHAGRNQLSLTS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC
YASNEIIGQHFGCLFLPEDLVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITA
CCCHHHHHHHCCEEEECHHHHCCCCHHHHHHHHHHCCEEECCEEEHHHHHHHHHHHHHHH
IHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNSEG
HCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
RVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPEGH
EEEEECCCHHHHHCCCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHCHHHCCCCCC
YLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLIN
HHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRRLEERLTLAINQLAHDGQHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRE
HHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHC
NDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQFHWHGQSYVLTASLGAIPLTQ
CCEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCC
QTESASQAMRLADIACYKAKHAGRNQLSLTS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]