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The map label for this gene is mmlH [H]

Identifier: 22126263

GI number: 22126263

Start: 2626946

End: 2628223

Strand: Direct

Name: mmlH [H]

Synonym: y2379

Alternate gene names: 22126263

Gene position: 2626946-2628223 (Clockwise)

Preceding gene: 22126262

Following gene: 22126264

Centisome position: 57.1

GC content: 50.31

Gene sequence:

>1278_bases
GTGAGGTGCTCACAAGAGTTAAAAAGCCAGTCTGTAAAGGAGATATTTATGCGTTGGTTTAGCGATCTCAACCAGACAGA
AAGAAAAACTTTCATTGCTGCTTTTGGCGGTTGGGCATTGGATGCGCTAGATTTCATGGTTTTTACATTCGTGATTGCTA
CGCTGATGGCTCTCTGGCAAATCGACGCAGGCCAGGCCGGAATGTTGAGCACCGTCACCCTGCTTTTCTCCGCTATTGGT
GGCTGGGGTGCGGGTATCCTTGCTGATCGTTATGGCAGGGTGCGTATCCTGCAAATAACTATTTTATGGTTCTCCTTATG
TACGGTACTCATCGGATTTGCTCAGAACTTCGAACACGTTTTCATCCTACGCGCGCTACAAGGTTTAGGTTTTGGTGGTG
AATGGGCCGTAGGTTCTGTATTGATGGGGGAAATCGTCCGCGCCGAACATCGCGGGAAAGCCGTAGGCACCGTGCAAAGT
GGATGGGCGATTGGTTGGGGTGCAGCAGCCTTGCTTTACACGCTAATGTTCTCGGTACTATCAGAGGAGTGGGCGTGGCG
CGCATTATTCTGGATTGGTGTGCTTCCCGCCCTTTTAGTACTCTACATACGTAAAAACGTCCCAGAACCCGCGTTATTCC
TGAAATCCCGCCACGAGCAGCAAGCCAAGGATCGACGCGTTTCTTCCTTCGCCATTTTCTCCCCCGCGCTACTCAAGACC
ACCGTTCTGGCTTCTTTACTCTGTACCGGAGTGCAAGGCGGCTACTACGCCATCACAACTTGGCTGCCCACTTTTCTCAA
ACTCGAACGCAATCTCTCGGTGATCGGTACTGGTGGGTATCTCATGGTGATTATATTTGGCTCTTTCGTCGGCTATATTT
GTGGCGCTTATCTCACCGACAAACTTGGGCGACGGGCAAATCTGATTATCTTCTCACTGCTGTCGTGTATAACAATTTTT
GCTTATACCCAACTTACGCTGACCAACACGCAGATGCTCGTTCTGGGATTCCCACTCGGCTTTTCGGCATCCGGGATCTT
CAGCGGCATGGGTGCCTTTCTCACTGAGCTTTTTCCTTCGGCGGTACGTGCTACAGGACAAGGTTTTACCTATAGTTTTG
GTCGTGCCGTCGGTGCACTCTTTCCGGGGCTGGTCGGCTATCTGAGTCAGTCAAGTAGTCTGGCATTTGCCATTGGAGTC
TTCGCTGGCAGTGCCTATTGCATCGTATTGGTAATGAGCCTATTGCTGCCCGAGACCAAAAATAAACAGCTAGAATAA

Upstream 100 bases:

>100_bases
ATTTGCTCGCCGCTTGGGTACCCGATGAGCAGGTGCGCAACCGGATCTTGGTCGATAACCCTGCTCGTCTATATGATTTT
TAAAAATAACAAAATAACTT

Downstream 100 bases:

>100_bases
GTGACGATTTATGGCCATGAGCATCAGACTGTTTCTCTGATATTTATGCTTCTAAGCTGCCTGTACAACAGTGAACAGAA
AGCAACGCATCCGTTTGGAT

Product: major facilitator superfamily permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRCSQELKSQSVKEIFMRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIG
GWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQS
GWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKT
TVLASLLCTGVQGGYYAITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCITIF
AYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAVGALFPGLVGYLSQSSSLAFAIGV
FAGSAYCIVLVMSLLLPETKNKQLE

Sequences:

>Translated_425_residues
MRCSQELKSQSVKEIFMRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIG
GWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQS
GWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKT
TVLASLLCTGVQGGYYAITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCITIF
AYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAVGALFPGLVGYLSQSSSLAFAIGV
FAGSAYCIVLVMSLLLPETKNKQLE
>Mature_425_residues
MRCSQELKSQSVKEIFMRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIG
GWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQS
GWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKT
TVLASLLCTGVQGGYYAITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCITIF
AYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAVGALFPGLVGYLSQSSSLAFAIGV
FAGSAYCIVLVMSLLLPETKNKQLE

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=446, Percent_Identity=22.8699551569507, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI213021148, Length=445, Percent_Identity=25.8426966292135, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082404, Length=374, Percent_Identity=29.144385026738, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082231, Length=464, Percent_Identity=27.5862068965517, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790550, Length=454, Percent_Identity=26.6519823788546, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788292, Length=433, Percent_Identity=24.0184757505774, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081723, Length=343, Percent_Identity=28.8629737609329, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082159, Length=390, Percent_Identity=25.3846153846154, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789941, Length=443, Percent_Identity=26.6365688487585, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788942, Length=331, Percent_Identity=24.1691842900302, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=444, Percent_Identity=25, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46455; Mature: 46455

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCSQELKSQSVKEIFMRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQ
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IDAGQAGMLSTVTLLFSAIGGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHH
FILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
SEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLASLLCTGVQGGYYAITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTD
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
KLGRRANLIIFSLLSCITIFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPS
HHCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
AVRATGQGFTYSFGRAVGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETK
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCC
NKQLE
CCCCC
>Mature Secondary Structure
MRCSQELKSQSVKEIFMRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQ
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IDAGQAGMLSTVTLLFSAIGGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHH
FILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
SEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLASLLCTGVQGGYYAITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTD
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
KLGRRANLIIFSLLSCITIFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPS
HHCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
AVRATGQGFTYSFGRAVGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETK
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCC
NKQLE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]