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The map label for this gene is lysN [H]

Identifier: 22126259

GI number: 22126259

Start: 2622569

End: 2623756

Strand: Reverse

Name: lysN [H]

Synonym: y2375

Alternate gene names: 22126259

Gene position: 2623756-2622569 (Counterclockwise)

Preceding gene: 22126261

Following gene: 22126256

Centisome position: 57.03

GC content: 47.22

Gene sequence:

>1188_bases
TTGGTTGACCTTTGTGGAAGAACTGCAATGAATAAAATTATAACGGATCAGCGTCACCAATTTTCCTCACGAGTGAATGA
CCTTCACCCGTCGCCAATTAGGGAAATACTGTCTGTCATTGATCGTCCGGGAATGATCTCGTTTGCCGGCGGATTACCCG
CAGTAGAAAGTTTTCCTCATATGAGCCTTGAGGGAATGCCGCAGCCGATGCTACAATATGGCGCGAGTGAAGGGGAGCTG
GAATTACGTCAACAGATTGCTCAAAATTTGTGTGAGCGAGGTTTATCCTGTACTGAGGAACAAGTCCTGATTATTTCAGG
CTCACAGCAGGGCATTGATCTGGTCGCTAAGTTGTTTATTGACGAGGGAACCCCCGTCGCCGTTGAATCGCCTACCTATC
TGGCTGCGTTACAGGTATTCCGTTTTTTCGGTGCTCAATTTGTGGCTTATGATTCAACTCAGCCTGATATCGACAAGCTT
CGCACCGAAAAACCTGCTTTTGCTTATACTATTCCGACCTTCCAGAATCCAAGCGGTCACTGCCTTGATACTGAACAACG
AGAGTTACTGGCGAAGACATGTGATGACATTATGTTACCGCTCTTTGAAGATGACCCGTACCATGACTTGGTTTATGACC
CTTGTGAGCGTAAGCCAGTGTGTGCTTCATTACAGCGAGCTTCGTGGATTTACCAAGGATCTTTTTCTAAAAGTTTATCC
CCGGCGCTGCGTTTGGGCTATCTTGTCGCATCTTCAGAATTGATTCCCTATTTGACACGTTTAAAACAAGCCGCAGATTT
GCACAGCAGCCGGATCAGCCAATGGTTAGTGTTACAGCAGTTGCGTAGCCCTAGGCATACTGAGCATATGCATGAACTGG
CAGCCTATTATCGAACTCGCCGTGATGCGTTTGAAATCTCCCTACAACGCCATTTTGGCTCTCTTGCGACGTGGAAAAAA
CCGGCTGGAGGGCTGTTCTTCTGGTTAACCCTTAATCGCTGCATAGATACTCGTCAACTCTTGCCTAAAGCGCTGGCAAG
CAATATTGCATTTATGCCCGGAGAGTCGTTCCTCCCTCATTCATCTGAAGGCTGCGGTCAGTTACGGCTTAATTTTAGCC
ATGCGACGGAAGAACAAGCGGATGTAGGGCTGAAAATATTAGCGGGTTTAGTGCAGGAACATGCATAA

Upstream 100 bases:

>100_bases
TCGGTGTATCAATAAGACCCTGTTAGTGTTAGCAATAGGGTAGAAAGTGAAATTATGTTGACGTAATGAGCAGCGCATTT
TACTTTCCATAAATGCCAAA

Downstream 100 bases:

>100_bases
GATGGGCTATCGGTGAATCTCATTGACTCATTAATTGAAGACGCTGAATGAATCGAAATAAATTTCAGATGGACCGAGTA
ACGAAAGCTGCCAACGCACA

Product: aminotransferase

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MVDLCGRTAMNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQPMLQYGASEGEL
ELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVESPTYLAALQVFRFFGAQFVAYDSTQPDIDKL
RTEKPAFAYTIPTFQNPSGHCLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLS
PALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRRDAFEISLQRHFGSLATWKK
PAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHSSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA

Sequences:

>Translated_395_residues
MVDLCGRTAMNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQPMLQYGASEGEL
ELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVESPTYLAALQVFRFFGAQFVAYDSTQPDIDKL
RTEKPAFAYTIPTFQNPSGHCLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLS
PALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRRDAFEISLQRHFGSLATWKK
PAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHSSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA
>Mature_395_residues
MVDLCGRTAMNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQPMLQYGASEGEL
ELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVESPTYLAALQVFRFFGAQFVAYDSTQPDIDKL
RTEKPAFAYTIPTFQNPSGHCLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLS
PALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRRDAFEISLQRHFGSLATWKK
PAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHSSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=410, Percent_Identity=28.780487804878, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI33469970, Length=410, Percent_Identity=28.780487804878, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1787710, Length=378, Percent_Identity=25.6613756613757, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790797, Length=284, Percent_Identity=24.6478873239437, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356535, Length=359, Percent_Identity=23.6768802228412, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 44311; Mature: 44311

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLCGRTAMNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPH
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHCCC
MSLEGMPQPMLQYGASEGELELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFI
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHH
DEGTPVAVESPTYLAALQVFRFFGAQFVAYDSTQPDIDKLRTEKPAFAYTIPTFQNPSGH
CCCCCEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCCC
CLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLS
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCC
PALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RDAFEISLQRHFGSLATWKKPAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPH
HHHHHHHHHHHHCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
SSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDLCGRTAMNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPH
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHCCC
MSLEGMPQPMLQYGASEGELELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFI
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHH
DEGTPVAVESPTYLAALQVFRFFGAQFVAYDSTQPDIDKLRTEKPAFAYTIPTFQNPSGH
CCCCCEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCCC
CLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLS
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCC
PALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RDAFEISLQRHFGSLATWKKPAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPH
HHHHHHHHHHHHCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
SSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA