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The map label for this gene is trpA [H]

Identifier: 22125938

GI number: 22125938

Start: 2253591

End: 2254466

Strand: Reverse

Name: trpA [H]

Synonym: y2047

Alternate gene names: 22125938

Gene position: 2254466-2253591 (Counterclockwise)

Preceding gene: 161484807

Following gene: 22125937

Centisome position: 49.0

GC content: 48.29

Gene sequence:

>876_bases
ATGGAGCGTTATCAGCAACTTTTTAAGCAGTTAGCCGCCAAAAAAGAAGGTGCCTTTGTTCCTTTCGTCCAGCTTGGCGA
TCCCTCTCCGGCGATGTCACTCAATATTATTGATACGTTAATTGCGGCAGGTGCAGATGCATTAGAGTTAGGGATTCCGT
TCTCTGATCCGTTGGCTGATGGCCCTACCATACAAAATGCGGCGCTGCGTGCCTTTGCTGCGGGTGTCACTCCGGGTATT
TGTTTTGAAATACTGGCCGAAATCCGCCAAAAACACCCCACAATACCTATTGGCCTGTTGATGTATGCAAATCTGGTATT
CCACAATGGTATTGATCACTTCTACCAGCGCTGTGCTGAGGTGGGTGTCGATTCGGTGCTAATTGCTGATGTGCCATTTG
AAGAGTCTGCCCCTTTCCGGGCAGCGGCCTTACGTCACGGGATTGCACCCATTTTCATCTGCCCGCCTAATGCCGACGAT
GACTTACTGCGAGAAATCGCTTCTCATGGTCGTGGTTATACTTACCTGTTATCACGTGCCGGAGTCACCGGTGCAGAAAA
TCACGGCCAGTTACCGTTAAACCATCTGGTAGATAAACTGCGTGAATATAATGCAGCGCCCGCATTGCAGGGCTTTGGTA
TTTCAGAACCCGCGCAAGTAAAAGCCAGCCTGGCGGCGGGCGCGGCGGGTGCTATTTCAGGCTCAGCAATCGTCAAAATC
ATTGAAAAAAATGTTGCACAACCCGTTGAAATGTTAGTTCACGCTAACCCGCTTCGTCACAGAGATGAAAGCGGCAACCC
GCAGCTAGTTATTATTTACAATTGGTTACTATTGAGAGTGAGTTACCGTTTAGAATTAATTACTATTTACCGTTAA

Upstream 100 bases:

>100_bases
ATCCGGATAAAGAACAAATACTGGTGGTGAATCTCTCCGGCCGGGGTGACAAAGATATTTTCACCGTTCACGATATTCTG
AAAGCACGGGGAGAGATTTA

Downstream 100 bases:

>100_bases
CTGCTGTCATTACCGCCCTTCAGCGCCTGTTTGTTTACATGAAACAGGCGCTATTTTCAGCCATTTCTTGGGCTATTTCC
GTTATAAATTTGTAGCAAAT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPGI
CFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADD
DLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
IEKNVAQPVEMLVHANPLRHRDESGNPQLVIIYNWLLLRVSYRLELITIYR

Sequences:

>Translated_291_residues
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPGI
CFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADD
DLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
IEKNVAQPVEMLVHANPLRHRDESGNPQLVIIYNWLLLRVSYRLELITIYR
>Mature_291_residues
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPGI
CFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADD
DLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
IEKNVAQPVEMLVHANPLRHRDESGNPQLVIIYNWLLLRVSYRLELITIYR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=252, Percent_Identity=80.1587301587302, Blast_Score=394, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321412, Length=240, Percent_Identity=31.6666666666667, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 31474; Mature: 31474

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLAD
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQNAALRAFAAGVTPGICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
VGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADDDLLREIASHGRGYTYLLSRA
CCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECC
GVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
IEKNVAQPVEMLVHANPLRHRDESGNPQLVIIYNWLLLRVSYRLELITIYR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHEEEEEEEEC
>Mature Secondary Structure
MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLAD
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQNAALRAFAAGVTPGICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAE
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
VGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADDDLLREIASHGRGYTYLLSRA
CCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECC
GVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
IEKNVAQPVEMLVHANPLRHRDESGNPQLVIIYNWLLLRVSYRLELITIYR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA