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The map label for this gene is sapA [H]

Identifier: 22125869

GI number: 22125869

Start: 2177877

End: 2179523

Strand: Reverse

Name: sapA [H]

Synonym: y1977

Alternate gene names: 22125869

Gene position: 2179523-2177877 (Counterclockwise)

Preceding gene: 161484812

Following gene: 22125868

Centisome position: 47.37

GC content: 49.0

Gene sequence:

>1647_bases
ATGCGTGGTTTACTGATTTTGCTGTTGTCGCTGATTTGCCTTGCAACCCCTGTGCTGGCACAACCTGTTGCAGCGGAGCA
ACCGCTACCGGATATCCGTCAGCGCGGATTTGTCTATTGTGTCAGTGGGATACTCAACACATTTAACCCCCAAATGGCCA
GTAGCGGTTTAACCGTCGATACACTTGCAGCACAACTCTATGACCGTCTACTGGATGTTGACCCCTATACCTACCGGTTA
ATCCCAGAACTGGCGGAAAGTTGGCAAGTTCTGGATAACGGCGCAACCTACCGTTTTCATTTACGTAAAGATGTGCCATT
TCAGACTACCGACTGGTTTACGCCTACGCGGATGATGAACGCCGATGATGTGGTCTTCAGTTTTCAGCGAGTATTTGACT
CAAAGCATCCGTACCACAAGGTCAACGGCGGAGAGTACCCCTACTTTGATAGTTTGCAGTTTGCAAGCGCCGTAAAAAGC
GTAAAAAAATTGGATGATTACACCGTTGAATTTAAGCTAAAAGCCCCAGATGCGTCGTTTCTTTGGCATTTAGCAACTCA
TTACGCCCCCGTATTGTCTTCAGAATACGCCGATGTCCTGACCCAGAAAGGGAAGGAAGAACAGATTGACCGTGAGCCAG
TCGGGACCGGGCCTTTTCTATTGGATGAATATCGTTCTGGGCAATATATCCGCTTGTTCCGCAACAGCCACTATTGGAAA
GGTGTGCCACGTATGCCACAGGTGGTTATCGACTTAGGGGTCGGTGGAACGGGGCGTTTATCAAAACTGTTGACCGGAGA
GTGTGATGTGCTGGCCTATCCCGCCGCCAGCCAATTATCTATTTTACGTGATGACCCACCACGCCTACGCCTGACACTGC
GCCCTGGGATGAACGTCGCCTATCTCGCCTTCAATACCCGCAAGCCCCCGTTAAGTGATCAACGGGTTCGCCAAGCGATC
GCTTTGTCGATCAATAACCAACGATTGATGCAATCAATCTATTACGGCACAGCTGAAACGGCAGCCTCTATTTTACCTAG
AGCATCATGGGCTTATGATAATCAGGCGCAGGTGACCGAATATAATCCGGAAAAAGCCAAAGAGATCCTCAAAGATTTGG
GGATAACCCAACTGCAACTTAACTTATGGGTCCCTACTGCATCGCAATCTTATAATCCTAGCCCATTGAAAACTGCTGAA
TTGATCCAAGCGGATTTAGCACAAGTGGGGATTTCCGTCACTATTGTTCCCGTCGAGGGCCGTTTCCAAGAGGCCCGTCT
GATGGAGATGAACCACGATCTGACACTTTCCGGTTGGTCTACTGACAGTAATGACCCCGACAGTTTCTTCCGGCCATTAT
TAAGCTGTGCAGCAATTCGTTCGCAAACAAACTATGCTCACTGGTGTGATCCGGCCTTTGATGAATTACTGCAAAAGGCA
TTACGTTCCCAACAATTATCGGAGCGTATTGAGTATTATCAGCAGGCTCAGCGTATTCTGGAGCAACAATTGCCGTTACT
GCCACTGGCATCGTCCCTGCGGCTTCAGGCATACCGTTATGACATTAAAGGCTTGGTATTAAGCCCGTTCGGTAACTCTT
CTTTCGCCGGTGTATACCGCGAAAGCGATGAGGGCAAGACGCCATGA

Upstream 100 bases:

>100_bases
GCAATCCCCTCAGATGAAACAGTTGTTTTGTGCAATGGATTGGGGGGATCGTCAGATTACGGTACACTAAGCGTATTGCT
TACTCACTGCGAAAGCGTTT

Downstream 100 bases:

>100_bases
TTATTTTCACATTACGGCGATTATTACTGCTCGTGATAACCCTGTTTATGTTGTCATTAGTCAGCTTTAGCCTGAGCTAT
TTTACCCCCTATGCACCGTT

Product: peptide transport periplasmic protein precursor

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVDTLAAQLYDRLLDVDPYTYRL
IPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMNADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKS
VKKLDDYTVEFKLKAPDASFLWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPPRLRLTLRPGMNVAYLAFNTRKPPLSDQRVRQAI
ALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEYNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAE
LIQADLAQVGISVTIVPVEGRFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKA
LRSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRESDEGKTP

Sequences:

>Translated_548_residues
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVDTLAAQLYDRLLDVDPYTYRL
IPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMNADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKS
VKKLDDYTVEFKLKAPDASFLWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPPRLRLTLRPGMNVAYLAFNTRKPPLSDQRVRQAI
ALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEYNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAE
LIQADLAQVGISVTIVPVEGRFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKA
LRSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRESDEGKTP
>Mature_548_residues
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVDTLAAQLYDRLLDVDPYTYRL
IPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMNADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKS
VKKLDDYTVEFKLKAPDASFLWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPPRLRLTLRPGMNVAYLAFNTRKPPLSDQRVRQAI
ALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTEYNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAE
LIQADLAQVGISVTIVPVEGRFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKA
LRSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYRESDEGKTP

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1787551, Length=545, Percent_Identity=76.1467889908257, Blast_Score=845, Evalue=0.0,
Organism=Escherichia coli, GI1789966, Length=540, Percent_Identity=38.3333333333333, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1787052, Length=513, Percent_Identity=26.3157894736842, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1787762, Length=493, Percent_Identity=24.7464503042596, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789397, Length=527, Percent_Identity=28.0834914611006, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1789887, Length=456, Percent_Identity=25, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1787495, Length=492, Percent_Identity=25.8130081300813, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081878, Length=455, Percent_Identity=25.2747252747253, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 61899; Mature: 61899

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00027 HOMEOBOX_1 ; PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHCCHHHHCCCCHHH
TLAAQLYDRLLDVDPYTYRLIPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHCCC
ADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKSVKKLDDYTVEFKLKAPDASF
CHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHH
LWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCC
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPPRLRLTLRPGMNVA
CCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCHHHHHHCCCCCCCEEEEECCCCCEE
YLAFNTRKPPLSDQRVRQAIALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTE
EEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEEC
YNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAELIQADLAQVGISVTIVPVEG
CCHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCC
RFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKA
CCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECEEEECCCCCCCCCEEEE
ESDEGKTP
ECCCCCCC
>Mature Secondary Structure
MRGLLILLLSLICLATPVLAQPVAAEQPLPDIRQRGFVYCVSGILNTFNPQMASSGLTVD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHCCHHHHCCCCHHH
TLAAQLYDRLLDVDPYTYRLIPELAESWQVLDNGATYRFHLRKDVPFQTTDWFTPTRMMN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHCCC
ADDVVFSFQRVFDSKHPYHKVNGGEYPYFDSLQFASAVKSVKKLDDYTVEFKLKAPDASF
CHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHH
LWHLATHYAPVLSSEYADVLTQKGKEEQIDREPVGTGPFLLDEYRSGQYIRLFRNSHYWK
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCC
GVPRMPQVVIDLGVGGTGRLSKLLTGECDVLAYPAASQLSILRDDPPRLRLTLRPGMNVA
CCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCHHHHHHCCCCCCCEEEEECCCCCEE
YLAFNTRKPPLSDQRVRQAIALSINNQRLMQSIYYGTAETAASILPRASWAYDNQAQVTE
EEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEEC
YNPEKAKEILKDLGITQLQLNLWVPTASQSYNPSPLKTAELIQADLAQVGISVTIVPVEG
CCHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCC
RFQEARLMEMNHDLTLSGWSTDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPAFDELLQKA
CCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRSQQLSERIEYYQQAQRILEQQLPLLPLASSLRLQAYRYDIKGLVLSPFGNSSFAGVYR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECEEEECCCCCCCCCEEEE
ESDEGKTP
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223423; 11677609 [H]