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The map label for this gene is btuC [H]

Identifier: 22125807

GI number: 22125807

Start: 2107432

End: 2108508

Strand: Direct

Name: btuC [H]

Synonym: y1914

Alternate gene names: 22125807

Gene position: 2107432-2108508 (Clockwise)

Preceding gene: 22125806

Following gene: 22125808

Centisome position: 45.81

GC content: 48.65

Gene sequence:

>1077_bases
ATGGGCAGTAGGCCCTTGTATGTTTACCCGACCTATTCGGGTAAGTCTTGGGTAATGGCCGAGGGTGTAATGCAGACAAG
TCAGTTATTTACCGCACTTCAACAACGGCAGCGGCAGCGCGACTATCGTTATCTTACTGGGCTGGTTGTCATGCTTTTGT
TCGCGCTACTCATCAGTTTATGTGCGGGTGATGTCTGGATTTGGCCAGAGCATTGGTTCAGTGAAAGTGGCAAATTATTT
GTTTGGCAACTACGTTTGCCCCGATCTATGGCTGTAATTATGGTTGGTGCCAGTCTGGCCGTGTCGGGTGCCGTGATGCA
GGCACTGTTTGAAAATCCGTTAGCTGAACCAGGTCTACTTGGCGTGGCAAATGGCGCAGGTGTTGCATTGGTGACGGCCG
TATTATTAGGTCATGGATTATTGCCAATTTGGGTTCTGAGCACGTGTGCTATTATTGGCGCATTGTTGATGACATCTATT
CTGTTAAGTTTCACCCGTCGCCGTTTATTAACTAATGCCCAGCTATTATTGGTCGGTGTAGCCTTAGGTATTATTTGCAG
TGCAATGATGACTTGGGCCGTCTATTTCAGCACCAGTTTGGATTTACGTCAGCTCATGTATTGGATGATGGGTGGGTTCA
GCGGTGTTGACTGGCGTCAGCAAAGTTTGGTGCTGGCTCTCTTGCCTACCGTCATATGGCTTTGCTGCCAAGGCCGTGTC
CTGAACTTCATGTCACTCGGTGAGCAGCAGGCCAGGCAATTGGGGGTGTCGCTTCATTTATGGCGGAATTTATTAGTACT
GGCGATCGGATTACTGGTCGGCATTAGTGTTGCACTCGCGGGTGTCATCAGTTTTATTGGCTTGGTTATTCCTCATATTT
TACGGTTAACCGGTTTAACTGATCAGCGCCGGCTATTAGCGGGCTGTGCATTCGCCGGCGGGGGGGTATTATTATTAGCT
GATGTTGTCGCTCGCACGGTATTATCTTCGGCAGAGCTACCGATTGGTGTGGTTACCGCAACATTAGGATCGCCATTATT
TATCTGGTTACTGATACGGGTGAAAGGAGTAAAGTGA

Upstream 100 bases:

>100_bases
CGACTTATTAGCAATAAAGAGCGTTTTAGCAATAAAGAGCGTTATTCGCCACGCACAACTTCCCCTTCACGCTCTAACCC
CCTAATATCAGTGCCTGAGA

Downstream 100 bases:

>100_bases
TTTGTCTTCTTATAAATGCCGCGGTGATTTTACCGGTTTATTATCATTACTGAATAAGGATCCAACCTGATGAGTCACCC
AATTTACGCCATTTCAGTGC

Product: vtamin B12-transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MGSRPLYVYPTYSGKSWVMAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLF
VWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSI
LLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRV
LNFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLA
DVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK

Sequences:

>Translated_358_residues
MGSRPLYVYPTYSGKSWVMAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLF
VWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSI
LLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRV
LNFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLA
DVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
>Mature_357_residues
GSRPLYVYPTYSGKSWVMAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFV
WQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSIL
LSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVL
NFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLAD
VVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane [H]

COG id: COG4139

COG function: function code H; ABC-type cobalamin transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=325, Percent_Identity=68, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790740, Length=293, Percent_Identity=36.518771331058, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=33.6879432624113, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786347, Length=322, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786805, Length=283, Percent_Identity=35.3356890459364, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786804, Length=285, Percent_Identity=32.6315789473684, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 38893; Mature: 38762

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSRPLYVYPTYSGKSWVMAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISL
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLL
HCCCEEECCHHHHCCCCCEEEEEEECCCHHHHHEECHHHHHHHHHHHHHHHCCCCCCCCE
GVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGV
EECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
LNFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLT
HHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSRPLYVYPTYSGKSWVMAEGVMQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLL
HCCCEEECCHHHHCCCCCEEEEEEECCCHHHHHEECHHHHHHHHHHHHHHHCCCCCCCCE
GVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGV
EECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
LNFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLT
HHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA