| Definition | Yersinia pestis KIM 10 chromosome, complete genome. |
|---|---|
| Accession | NC_004088 |
| Length | 4,600,755 |
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The map label for this gene is purB [H]
Identifier: 22125691
GI number: 22125691
Start: 1976919
End: 1978298
Strand: Reverse
Name: purB [H]
Synonym: y1797
Alternate gene names: 22125691
Gene position: 1978298-1976919 (Counterclockwise)
Preceding gene: 22125692
Following gene: 22125690
Centisome position: 43.0
GC content: 47.54
Gene sequence:
>1380_bases TTGCCACCAATGGAATTATCCTCACTGACCGCCGTTTCACCAATTGATGGACGTTACGGCGACAAAGTCAGCGCACTGCG CCCCATCTTTAGCGAATTCGGTTTGCTAAAATTCCGTGTGCAGGTCGAAGTGCGTTGGCTGCAAAAACTGGCAGCCTGCG CAGAAATTAAAGAGGTTCCTGCTTTTGATGCCAACGCAAACGCTTACCTTGATAAAATTGTGCAAGAGTTCAATGAACAA GATGCACAACGCATTAAGACCATCGAACGCACAACCAATCATGATGTGAAGGCTGTCGAGTATTTTCTGAAAGAAAAAGT GGAAAATCTCCCTGCGTTACATGCCGTGTCTGAGTTCATTCACTTTGCTTGTACTTCAGAAGATATCAATAACCTGTCCC ACGCATTGATGCTGCAAACTGCTCGCCAGGATGTCCTGCTGCCCGCATGGCGGCAGATTATTGACTCAATAAAAGCACTG GCCCACCAATATCGCGATTTACCCTTACTGTCCCGCACCCACGGCCAGCCCGCGACACCCTCAACCATCGGTAAAGAGCT GGCGAATGTGGCGTACCGCATGGAACGTCAGTTCCGCCAACTAACACAAGTGGAAATTCTGGGTAAAATCAACGGTGCAG TAGGCAACTATAACGCCCACATCGTGGCCTACCCTGAGGTTGATTGGCATCAGTTTAGTGAAAGTTTTGTGACATCGCTG GGAATCAACTGGAACCCATACACCACGCAAATCGAGCCTCATGATTATATTGCTGAGTTATTTGACTGTGTGGCCCGTTT CAATACTATTTTGATCGATTTTGACCGTGATATCTGGGGTTATATTGCTCTGAATCACTTCAAGCAAAAAACCATCGCGG GCGAAATCGGTTCAAGCACCATGCCGCATAAAGTTAATCCAATTGATTTCGAAAACTCGGAAGGCAATTTGGGTCTATCG AATGCCGTGCTAGGTCACATGGCCAGCAAACTACCGGTTTCTCGCTGGCAACGTGATCTGACCGACTCGACCGTGCTACG TAATCTGGGTGTGGGTCTGGGTTATGCCCTGATTGCCTATCAGGCAACCATGAAAGGCATCAGCAAACTGGAAGTTAACG AAGCACATCTGTTGCAAGAGCTTGATCATAATTGGGAAGTTCTGGCTGAACCTATTCAAACGATCATGCGCCGTTACGGT ATTGAAAAACCGTATGAAAAACTGAAAGAATTGACCCGTGGCAAACGTGTCGATGCCGCAGGTATGCAAGCATTTATCGA TGGGCTGGATCTACCAGAAGAAGAAAAAAACCGGTTGAAGGCCATGACGCCAGCGAATTACATTGGCCGCGCCACCACCA TGGTTGATGAATTAAAGTAA
Upstream 100 bases:
>100_bases GCGTAACCGTCTGTTTAAACAGGCACAGAGCATTCTTGCCCATACCTAATTCTTGCTCATACCTCATTGAAATATGAACG TTAAAATCTGACCTCAGGAG
Downstream 100 bases:
>100_bases TATTCTTTATCTAATACAGGTGGCTTAGTTTGGTAAAAGCTAACGCCATCTGTATTATTCCTTCCCCCCCTTTCCCAACG CCTCCCCCACTAACCTTCGC
Product: adenylosuccinate lyase
Products: NA
Alternate protein names: ASL; Adenylosuccinase; ASase [H]
Number of amino acids: Translated: 459; Mature: 458
Protein sequence:
>459_residues MPPMELSSLTAVSPIDGRYGDKVSALRPIFSEFGLLKFRVQVEVRWLQKLAACAEIKEVPAFDANANAYLDKIVQEFNEQ DAQRIKTIERTTNHDVKAVEYFLKEKVENLPALHAVSEFIHFACTSEDINNLSHALMLQTARQDVLLPAWRQIIDSIKAL AHQYRDLPLLSRTHGQPATPSTIGKELANVAYRMERQFRQLTQVEILGKINGAVGNYNAHIVAYPEVDWHQFSESFVTSL GINWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDIWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLS NAVLGHMASKLPVSRWQRDLTDSTVLRNLGVGLGYALIAYQATMKGISKLEVNEAHLLQELDHNWEVLAEPIQTIMRRYG IEKPYEKLKELTRGKRVDAAGMQAFIDGLDLPEEEKNRLKAMTPANYIGRATTMVDELK
Sequences:
>Translated_459_residues MPPMELSSLTAVSPIDGRYGDKVSALRPIFSEFGLLKFRVQVEVRWLQKLAACAEIKEVPAFDANANAYLDKIVQEFNEQ DAQRIKTIERTTNHDVKAVEYFLKEKVENLPALHAVSEFIHFACTSEDINNLSHALMLQTARQDVLLPAWRQIIDSIKAL AHQYRDLPLLSRTHGQPATPSTIGKELANVAYRMERQFRQLTQVEILGKINGAVGNYNAHIVAYPEVDWHQFSESFVTSL GINWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDIWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLS NAVLGHMASKLPVSRWQRDLTDSTVLRNLGVGLGYALIAYQATMKGISKLEVNEAHLLQELDHNWEVLAEPIQTIMRRYG IEKPYEKLKELTRGKRVDAAGMQAFIDGLDLPEEEKNRLKAMTPANYIGRATTMVDELK >Mature_458_residues PPMELSSLTAVSPIDGRYGDKVSALRPIFSEFGLLKFRVQVEVRWLQKLAACAEIKEVPAFDANANAYLDKIVQEFNEQD AQRIKTIERTTNHDVKAVEYFLKEKVENLPALHAVSEFIHFACTSEDINNLSHALMLQTARQDVLLPAWRQIIDSIKALA HQYRDLPLLSRTHGQPATPSTIGKELANVAYRMERQFRQLTQVEILGKINGAVGNYNAHIVAYPEVDWHQFSESFVTSLG INWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDIWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLSN AVLGHMASKLPVSRWQRDLTDSTVLRNLGVGLGYALIAYQATMKGISKLEVNEAHLLQELDHNWEVLAEPIQTIMRRYGI EKPYEKLKELTRGKRVDAAGMQAFIDGLDLPEEEKNRLKAMTPANYIGRATTMVDELK
Specific function: De novo purine biosynthesis; eighth step. [C]
COG id: COG0015
COG function: function code F; Adenylosuccinate lyase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily [H]
Homologues:
Organism=Escherichia coli, GI1787376, Length=456, Percent_Identity=88.5964912280702, Blast_Score=848, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013539 - InterPro: IPR000362 - InterPro: IPR020557 - InterPro: IPR008948 - InterPro: IPR022761 - InterPro: IPR004769 [H]
Pfam domain/function: PF08328 ASL_C; PF00206 Lyase_1 [H]
EC number: =4.3.2.2 [H]
Molecular weight: Translated: 51962; Mature: 51831
Theoretical pI: Translated: 6.16; Mature: 6.16
Prosite motif: PS00163 FUMARATE_LYASES
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPPMELSSLTAVSPIDGRYGDKVSALRPIFSEFGLLKFRVQVEVRWLQKLAACAEIKEVP CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCC AFDANANAYLDKIVQEFNEQDAQRIKTIERTTNHDVKAVEYFLKEKVENLPALHAVSEFI CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHH HFACTSEDINNLSHALMLQTARQDVLLPAWRQIIDSIKALAHQYRDLPLLSRTHGQPATP HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCH STIGKELANVAYRMERQFRQLTQVEILGKINGAVGNYNAHIVAYPEVDWHQFSESFVTSL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHC GINWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDIWGYIALNHFKQKTIAGEIGSST CCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC MPHKVNPIDFENSEGNLGLSNAVLGHMASKLPVSRWQRDLTDSTVLRNLGVGLGYALIAY CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH QATMKGISKLEVNEAHLLQELDHNWEVLAEPIQTIMRRYGIEKPYEKLKELTRGKRVDAA HHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHH GMQAFIDGLDLPEEEKNRLKAMTPANYIGRATTMVDELK HHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCC >Mature Secondary Structure PPMELSSLTAVSPIDGRYGDKVSALRPIFSEFGLLKFRVQVEVRWLQKLAACAEIKEVP CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCC AFDANANAYLDKIVQEFNEQDAQRIKTIERTTNHDVKAVEYFLKEKVENLPALHAVSEFI CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHH HFACTSEDINNLSHALMLQTARQDVLLPAWRQIIDSIKALAHQYRDLPLLSRTHGQPATP HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCH STIGKELANVAYRMERQFRQLTQVEILGKINGAVGNYNAHIVAYPEVDWHQFSESFVTSL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHC GINWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDIWGYIALNHFKQKTIAGEIGSST CCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC MPHKVNPIDFENSEGNLGLSNAVLGHMASKLPVSRWQRDLTDSTVLRNLGVGLGYALIAY CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH QATMKGISKLEVNEAHLLQELDHNWEVLAEPIQTIMRRYGIEKPYEKLKELTRGKRVDAA HHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHH GMQAFIDGLDLPEEEKNRLKAMTPANYIGRATTMVDELK HHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12471157 [H]