Click here to switch to the map view.

The map label for this gene is clpB [H]

Identifier: 22125435

GI number: 22125435

Start: 1702814

End: 1705564

Strand: Direct

Name: clpB [H]

Synonym: y1538

Alternate gene names: 22125435

Gene position: 1702814-1705564 (Clockwise)

Preceding gene: 22125433

Following gene: 22125436

Centisome position: 37.01

GC content: 47.55

Gene sequence:

>2751_bases
ATGGTGCATCAAGCATTATTTCATGAACAATTTAAACTACACATGAACGCCGTTAAAAAGACCAGGATAAAAAACGTGGC
TATTACAAGGAAACATCTCTTCGGCAAGCTGGACGCCACTCTTTTCAAAGGTATTGAAAGCGCAACAACGATTTGTAAAT
TACGCGGCAATCCTTACGTAGAGTTAGTTCACTGGTTGAATCAGCTTTGGCATCAGGAAGATAACGACCTTAAGCAGATT
ATTCGGTATTTTGCGGTGGATGTGGATGCCTTTGAGCGTGAACTGGCTCAGGCACTTGCGAAGTTACCTGTTGGGGCAAC
TAGCATTTCAGATTTTTCGTATCATATTGAGTTGGCCACGGAACGGGCTTGGATCTATGCCAGCCTGGAGTGTTTAGATA
CCCGTATCCGCAGCGGACATCTGCTGCTTGCGCTATTAACCACAATGGAACTGCGGAGAGCTTTCTTTGCGATTGCGCCA
AGCATGGAAAAAATTCCATTAGAGCATTTAAGCAAAGATTTGAACTTCATTACGCAGGCATCACCAGAAGCGAATGAAGC
CGCCAGTGATGGCAGCCCGTTGTACGATGGTGCTTTACCTGGCGAAGCCAGTAATGCCATTGGTGCAGCCAAAAGTGGTG
GCGCACTGGCTCAATACACCACAGACCTCACGGCATTAGCACGTGAAGGCAAGATAGATCCGGTATTGGGACGTAATCAC
GAAATCAACACAATGGTTGATATTCTCTTGCGCCGTCGGCAGAACAACCCATTACTTACCGGTGACGCAGGGGTGGGTAA
AACCGCCATTGTTGAAGGGCTAGCATTGGCTATTGCTGCTGGCTCAATGCCACCAGCATTAAGCCAGGTAAGCCTGTTGT
CATTAGATATTGTGGCGCTCTCAGCGGGTGCCAGCATGAAAGGTGAATTTGAAGCGCGCCTGAAGAGTGTCTTGGATGAA
GCGATAGCGGCAGAAAAGCCCGTTATTTTGTTTATCGATGAAGTACACACACTTATTGGCGCGGGTGGCAATGCCGGGAC
CGGCGATGCGGCGAACTTATTGAAACCTGCATTGGCGCGTGGCCAGTTACGTACCATTGGTGCGACAACGTGGAGCGAGT
TCAAGCGTCACATTGAGAAGGATCCGGCACTCACCCGTCGTTTCCAAGTACTTCAAGTTGATGAGCCCGATGAGAACACG
GCGATCTCCATGTTACGGGGCCTGATACCTGCGCTAGAAAAGCACCACGGCGTGTGGATTATGGACGAAGCTTTACAGGC
GGCAGTACGGTTGTCTCATCGTTATATCCCTGCGCGTCAGTTGCCGGATAAAGCGATAAGTCTGCTTGATACGGCTTGTG
CACGGATCGCTGTCGCGCAGTTTTCACAACCAATAGAGCTACAGCACTTAACCTTCCAGAGTGAGACGGCGCAAACTGAG
CTGGTTTCCTTAGAGAAAGCGCGGCACTTTGGTAAAGCGCAGGATGCGCGTACTGAGCAGTTGAAAACATCCATTGCTGA
ACATGGCGAGGCTGCGGATAAGCTTGATCAGCGTTGGCAGGCAGAACGCGAATTGGTATCAGCGATTACGACCATAAGAA
CCGCACTGTATGACTTGGTTTCTCAGCCAGAGCCTGATGAGGAAAAACGTCGGGCTTATCAAGCGCAATTAGTTCAGTTG
GAAGCGCAGCTTTCTCAGGTTCGCACTTCACTGCCGTTAGTGCAGACAGAAGTCAACGCTGAAGTGATTGCCAGTATCGT
TGCGGATTGGACCGGCATTCCGGTTGGGCAAATGCTCAAAGACGATATTCGGGCGGTAATGGAGTTGCCACAGCGCCTTG
AAGCACGTGTTATTGGTCAGCCCCATGCATTGATGCAACTGGGTGAAAATATTATGACCGCACGCGCTGGCCTGTCAGAC
CCAAGGAAACCATTGGGGGTCTTTATGTTAGTGGGGCCTTCAGGTGTGGGTAAAACAGAGACGGCCTTAGCGATCGCCGA
GAGCATGTATGGTGGTGAACAGAATATGATCACTATCAATATGAGCGAATATCAGGAATCGCATACCGTTTCCTCTTTAA
AAGGTTCTCCACCGGGATATGTTGGATACGGTGAAGGCGGTGTGTTAACGGAAGCTGTGCGCCGTAAGCCATATAGTGTT
GTGTTGTTAGATGAAATCGAAAAAGCGCACTCTGATGTACATGAGTTATTCTTCCAAGTGTTTGATAAAGGCCAAATGGA
AGATGGTGAAGGGCGTTTTATCGATTTTAAAAATACTATCTTGTTGTTAACCAGTAATGTGGGCAGCGAGTTACTGAGTA
ACTTATTAGCTGATCCAGATACTGCACCGGATCAGGATGGAATATTAAGTGCGTTGCAACCTGAATTGCTGAAAGTTTTC
CCCGCAGCATTTTTAGGGCGAGTTACGGTTATTCCTTATCTTCCGTTACAGCAAGATGCATTGCAGCATATTGTACGGTT
GCATTTAGATCGGATTGGCGCTCGTTTATACTCGCAGCATCAATTGACACTGAAATACAGTGATGAAGTGGTTGAAGATG
TTGTTAGCCGCTGTGCGGTCTCAGAGACCGGTGCGCGTATGCTGATCCGTTACATTGAACAAAATATTACGCCAAAAATA
GGTAAATATATTTTAGGTGATAGTGATGTGAAGCCTGAGCAAATTATTTTCGTTCATAAAAATGAAAATGGATTCGTGAT
CGCTTTACAGTGTAAAGATGACGAAAACTAA

Upstream 100 bases:

>100_bases
CATGACATTAAGTCGAGCAAAATTCTTAAATTGATTGAAATTGAGTGAATGTTCTTTTCATTTTTATTTTTTCGATTAGT
CTTAGCCGCAGAAATAGTTC

Downstream 100 bases:

>100_bases
AGATATCACGTTTAAGCGGGTATCGATCCTATAGACTTTTATCTCAGTAATACTTATTGCAGATGGACATGCTAAAGGAT
GAAAAGGAATTTGCTATTTC

Product: Clp ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 916; Mature: 916

Protein sequence:

>916_residues
MVHQALFHEQFKLHMNAVKKTRIKNVAITRKHLFGKLDATLFKGIESATTICKLRGNPYVELVHWLNQLWHQEDNDLKQI
IRYFAVDVDAFERELAQALAKLPVGATSISDFSYHIELATERAWIYASLECLDTRIRSGHLLLALLTTMELRRAFFAIAP
SMEKIPLEHLSKDLNFITQASPEANEAASDGSPLYDGALPGEASNAIGAAKSGGALAQYTTDLTALAREGKIDPVLGRNH
EINTMVDILLRRRQNNPLLTGDAGVGKTAIVEGLALAIAAGSMPPALSQVSLLSLDIVALSAGASMKGEFEARLKSVLDE
AIAAEKPVILFIDEVHTLIGAGGNAGTGDAANLLKPALARGQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDENT
AISMLRGLIPALEKHHGVWIMDEALQAAVRLSHRYIPARQLPDKAISLLDTACARIAVAQFSQPIELQHLTFQSETAQTE
LVSLEKARHFGKAQDARTEQLKTSIAEHGEAADKLDQRWQAERELVSAITTIRTALYDLVSQPEPDEEKRRAYQAQLVQL
EAQLSQVRTSLPLVQTEVNAEVIASIVADWTGIPVGQMLKDDIRAVMELPQRLEARVIGQPHALMQLGENIMTARAGLSD
PRKPLGVFMLVGPSGVGKTETALAIAESMYGGEQNMITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSV
VLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLLADPDTAPDQDGILSALQPELLKVF
PAAFLGRVTVIPYLPLQQDALQHIVRLHLDRIGARLYSQHQLTLKYSDEVVEDVVSRCAVSETGARMLIRYIEQNITPKI
GKYILGDSDVKPEQIIFVHKNENGFVIALQCKDDEN

Sequences:

>Translated_916_residues
MVHQALFHEQFKLHMNAVKKTRIKNVAITRKHLFGKLDATLFKGIESATTICKLRGNPYVELVHWLNQLWHQEDNDLKQI
IRYFAVDVDAFERELAQALAKLPVGATSISDFSYHIELATERAWIYASLECLDTRIRSGHLLLALLTTMELRRAFFAIAP
SMEKIPLEHLSKDLNFITQASPEANEAASDGSPLYDGALPGEASNAIGAAKSGGALAQYTTDLTALAREGKIDPVLGRNH
EINTMVDILLRRRQNNPLLTGDAGVGKTAIVEGLALAIAAGSMPPALSQVSLLSLDIVALSAGASMKGEFEARLKSVLDE
AIAAEKPVILFIDEVHTLIGAGGNAGTGDAANLLKPALARGQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDENT
AISMLRGLIPALEKHHGVWIMDEALQAAVRLSHRYIPARQLPDKAISLLDTACARIAVAQFSQPIELQHLTFQSETAQTE
LVSLEKARHFGKAQDARTEQLKTSIAEHGEAADKLDQRWQAERELVSAITTIRTALYDLVSQPEPDEEKRRAYQAQLVQL
EAQLSQVRTSLPLVQTEVNAEVIASIVADWTGIPVGQMLKDDIRAVMELPQRLEARVIGQPHALMQLGENIMTARAGLSD
PRKPLGVFMLVGPSGVGKTETALAIAESMYGGEQNMITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSV
VLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLLADPDTAPDQDGILSALQPELLKVF
PAAFLGRVTVIPYLPLQQDALQHIVRLHLDRIGARLYSQHQLTLKYSDEVVEDVVSRCAVSETGARMLIRYIEQNITPKI
GKYILGDSDVKPEQIIFVHKNENGFVIALQCKDDEN
>Mature_916_residues
MVHQALFHEQFKLHMNAVKKTRIKNVAITRKHLFGKLDATLFKGIESATTICKLRGNPYVELVHWLNQLWHQEDNDLKQI
IRYFAVDVDAFERELAQALAKLPVGATSISDFSYHIELATERAWIYASLECLDTRIRSGHLLLALLTTMELRRAFFAIAP
SMEKIPLEHLSKDLNFITQASPEANEAASDGSPLYDGALPGEASNAIGAAKSGGALAQYTTDLTALAREGKIDPVLGRNH
EINTMVDILLRRRQNNPLLTGDAGVGKTAIVEGLALAIAAGSMPPALSQVSLLSLDIVALSAGASMKGEFEARLKSVLDE
AIAAEKPVILFIDEVHTLIGAGGNAGTGDAANLLKPALARGQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDENT
AISMLRGLIPALEKHHGVWIMDEALQAAVRLSHRYIPARQLPDKAISLLDTACARIAVAQFSQPIELQHLTFQSETAQTE
LVSLEKARHFGKAQDARTEQLKTSIAEHGEAADKLDQRWQAERELVSAITTIRTALYDLVSQPEPDEEKRRAYQAQLVQL
EAQLSQVRTSLPLVQTEVNAEVIASIVADWTGIPVGQMLKDDIRAVMELPQRLEARVIGQPHALMQLGENIMTARAGLSD
PRKPLGVFMLVGPSGVGKTETALAIAESMYGGEQNMITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSV
VLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLLADPDTAPDQDGILSALQPELLKVF
PAAFLGRVTVIPYLPLQQDALQHIVRLHLDRIGARLYSQHQLTLKYSDEVVEDVVSRCAVSETGARMLIRYIEQNITPKI
GKYILGDSDVKPEQIIFVHKNENGFVIALQCKDDEN

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=34.5637583892617, Blast_Score=159, Evalue=1e-38,
Organism=Escherichia coli, GI1788943, Length=726, Percent_Identity=41.4600550964187, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1787109, Length=321, Percent_Identity=39.8753894080997, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6320464, Length=688, Percent_Identity=41.4244186046512, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6323002, Length=702, Percent_Identity=36.039886039886, Blast_Score=430, Evalue=1e-121,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR017729
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 100759; Mature: 100759

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHQALFHEQFKLHMNAVKKTRIKNVAITRKHLFGKLDATLFKGIESATTICKLRGNPYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
ELVHWLNQLWHQEDNDLKQIIRYFAVDVDAFERELAQALAKLPVGATSISDFSYHIELAT
HHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
ERAWIYASLECLDTRIRSGHLLLALLTTMELRRAFFAIAPSMEKIPLEHLSKDLNFITQA
CCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCC
SPEANEAASDGSPLYDGALPGEASNAIGAAKSGGALAQYTTDLTALAREGKIDPVLGRNH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
EINTMVDILLRRRQNNPLLTGDAGVGKTAIVEGLALAIAAGSMPPALSQVSLLSLDIVAL
CHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHE
SAGASMKGEFEARLKSVLDEAIAAEKPVILFIDEVHTLIGAGGNAGTGDAANLLKPALAR
ECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
GQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDENTAISMLRGLIPALEKHHGVWI
CCCCEECCHHHHHHHHHHHCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEE
MDEALQAAVRLSHRYIPARQLPDKAISLLDTACARIAVAQFSQPIELQHLTFQSETAQTE
EHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
LVSLEKARHFGKAQDARTEQLKTSIAEHGEAADKLDQRWQAERELVSAITTIRTALYDLV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQPEPDEEKRRAYQAQLVQLEAQLSQVRTSLPLVQTEVNAEVIASIVADWTGIPVGQMLK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCCHHHHHH
DDIRAVMELPQRLEARVIGQPHALMQLGENIMTARAGLSDPRKPLGVFMLVGPSGVGKTE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHH
TALAIAESMYGGEQNMITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSV
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHCCCCEE
VLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLLADPD
EEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECHHHHHHHHHHHCCCC
TAPDQDGILSALQPELLKVFPAAFLGRVTVIPYLPLQQDALQHIVRLHLDRIGARLYSQH
CCCCCCCHHHHHHHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
QLTLKYSDEVVEDVVSRCAVSETGARMLIRYIEQNITPKIGKYILGDSDVKPEQIIFVHK
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCCCEEEEEEE
NENGFVIALQCKDDEN
CCCCEEEEEEECCCCC
>Mature Secondary Structure
MVHQALFHEQFKLHMNAVKKTRIKNVAITRKHLFGKLDATLFKGIESATTICKLRGNPYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
ELVHWLNQLWHQEDNDLKQIIRYFAVDVDAFERELAQALAKLPVGATSISDFSYHIELAT
HHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
ERAWIYASLECLDTRIRSGHLLLALLTTMELRRAFFAIAPSMEKIPLEHLSKDLNFITQA
CCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCC
SPEANEAASDGSPLYDGALPGEASNAIGAAKSGGALAQYTTDLTALAREGKIDPVLGRNH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
EINTMVDILLRRRQNNPLLTGDAGVGKTAIVEGLALAIAAGSMPPALSQVSLLSLDIVAL
CHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHE
SAGASMKGEFEARLKSVLDEAIAAEKPVILFIDEVHTLIGAGGNAGTGDAANLLKPALAR
ECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
GQLRTIGATTWSEFKRHIEKDPALTRRFQVLQVDEPDENTAISMLRGLIPALEKHHGVWI
CCCCEECCHHHHHHHHHHHCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEE
MDEALQAAVRLSHRYIPARQLPDKAISLLDTACARIAVAQFSQPIELQHLTFQSETAQTE
EHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
LVSLEKARHFGKAQDARTEQLKTSIAEHGEAADKLDQRWQAERELVSAITTIRTALYDLV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQPEPDEEKRRAYQAQLVQLEAQLSQVRTSLPLVQTEVNAEVIASIVADWTGIPVGQMLK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCCHHHHHH
DDIRAVMELPQRLEARVIGQPHALMQLGENIMTARAGLSDPRKPLGVFMLVGPSGVGKTE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHH
TALAIAESMYGGEQNMITINMSEYQESHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSV
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHCCCCEE
VLLDEIEKAHSDVHELFFQVFDKGQMEDGEGRFIDFKNTILLLTSNVGSELLSNLLADPD
EEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECHHHHHHHHHHHCCCC
TAPDQDGILSALQPELLKVFPAAFLGRVTVIPYLPLQQDALQHIVRLHLDRIGARLYSQH
CCCCCCCHHHHHHHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
QLTLKYSDEVVEDVVSRCAVSETGARMLIRYIEQNITPKIGKYILGDSDVKPEQIIFVHK
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCCCEEEEEEE
NENGFVIALQCKDDEN
CCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10986262 [H]