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The map label for this gene is cpxA [H]

Identifier: 22125380

GI number: 22125380

Start: 1646462

End: 1647811

Strand: Direct

Name: cpxA [H]

Synonym: y1483

Alternate gene names: 22125380

Gene position: 1646462-1647811 (Clockwise)

Preceding gene: 22125379

Following gene: 22125381

Centisome position: 35.79

GC content: 49.19

Gene sequence:

>1350_bases
ATGCGCGGAAGATTATTCTGGAAAATCCTGTTGGGTTTTTGGCTGACGTTTATTTTGATGACTCAGATGTTGTGGGTGAT
TTTTTCCTTTTATGGTCATCGCCATGAGCCACCAGAGAATGACCTCGTTCGGCAGATTGCCCGGTTGCAGGTTGTTTCAG
CCGCATCAGTATTACATACCGGCGGTCAGCCAGCCTTAAACGCTATGATGGCTGATTGGCCAGAAGCGGACAAAAAATAT
TTTTCTGTCTTACCTGCCGAGATGGCAGATACGGCAGAAAAAGATATATCGGCTCTCTCTGGGGAAGAACCTAAGTTATA
CAGTAGCGAAATCGTCACTTGGGTCACCGCACCTGACAAGGAAAACTACCGTGTCAGCTACGACATTGAAGGTTTACGCG
CAGCAAACTTGGCAAATGCCCCTGATAAACATCGCCGTGAAATACTGAATGTTCCTATCCCGATGATCTGGATGGGGGTA
TTAGGGGGCTTATTTTTCAGTACGTTATTAGCCTGGAACTTGACACGGCCCATGCGCCAATTACGTGTCGGTTTTGAACG
GGTAGCACAGGGGGATTTATCTGTGCGGTTGCTTCCAGTGATGCGCCGTCGGCATGATGAACTCACGGAAGTCGCGCGGG
ACTTTGACTCGATGGCCGAACGCCTACAGGCACTGGTCAGTGCACGTGAGCAATTATTGCATGACGTTTCTCATGAATTA
CGTTCTCCACTAGCCCGTTTACAATTGGCTATCGGTTTAGCGCATCAGAACCCTGACAACGTAGACAACGCATTACAGCG
CATCGAGCATGAGTCCGAACGGTTGGATAAGATGATTGGTGAATTATTGGCGCTATCGCGTGCTGAAAATCACAGCCTGG
CCGATGATGATGAGTATTTTGACTTACAGGAATTAGTTAAAGTCGTGGTGAATGATGCCCGCTACGAAGCACAACTGCCG
GGAGTTGAAATCCAGTTAGAGGTCGCGGCACAGAGTGAGTATACCGTAAAAGGTAATGCTGAACTGATGCGGCGTGCTAT
CGAAAATATTGTCCGCAATGCGCTACGGTTTTCAGCAAGTGGCCAACAGGTTAAGGTGACGCTCTCTGCGCTGGATAAGC
GCTATCAAATTCAGGTTGCAGACCAAGGCCCAGGGGTTGAGGAAAACAAACTATCCAGTATTTTTGACCCTTTTGTTCGT
GTTAAATCAGCGATGTCCGGCAAAGGATACGGCTTGGGGCTGGCGATTACGCATAAGGTGATTCTGGCTCATGGCGGTCA
GGTTGAGGCGCGAAATGGAGAGCAGGGTGGTCTGGTGATAACATTACGTGTGCCACGGTGGCAGGCCTGA

Upstream 100 bases:

>100_bases
CAGAAACTCGCCGCCCTACCGGGTAATCATTTAAATATTGAAACGGTACGTAGCATTGGCTATCGCATCCGATAACCGTC
ACTGCGGAGTGAGATAACCT

Downstream 100 bases:

>100_bases
GCGGTAAGCTGAGTGAATAAGGTGTAGTGAATGGATACGAGAGAAGGCCACTACGATAAGAGATAGGAAAGGCTAAAAGA
CCATCATGGCCGGCAGCAAA

Product: kinase sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHTGGQPALNAMMADWPEADKKY
FSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDKENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGV
LGGLFFSTLLAWNLTRPMRQLRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
RSPLARLQLAIGLAHQNPDNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYFDLQELVKVVVNDARYEAQLP
GVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSASGQQVKVTLSALDKRYQIQVADQGPGVEENKLSSIFDPFVR
VKSAMSGKGYGLGLAITHKVILAHGGQVEARNGEQGGLVITLRVPRWQA

Sequences:

>Translated_449_residues
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHTGGQPALNAMMADWPEADKKY
FSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDKENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGV
LGGLFFSTLLAWNLTRPMRQLRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
RSPLARLQLAIGLAHQNPDNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYFDLQELVKVVVNDARYEAQLP
GVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSASGQQVKVTLSALDKRYQIQVADQGPGVEENKLSSIFDPFVR
VKSAMSGKGYGLGLAITHKVILAHGGQVEARNGEQGGLVITLRVPRWQA
>Mature_449_residues
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHTGGQPALNAMMADWPEADKKY
FSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDKENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGV
LGGLFFSTLLAWNLTRPMRQLRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
RSPLARLQLAIGLAHQNPDNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYFDLQELVKVVVNDARYEAQLP
GVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSASGQQVKVTLSALDKRYQIQVADQGPGVEENKLSSIFDPFVR
VKSAMSGKGYGLGLAITHKVILAHGGQVEARNGEQGGLVITLRVPRWQA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=34.1818181818182, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=29.3906810035842, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=28.6764705882353, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1787894, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1789808, Length=306, Percent_Identity=28.4313725490196, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=258, Percent_Identity=27.1317829457364, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=330, Percent_Identity=28.1818181818182, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790551, Length=303, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790861, Length=345, Percent_Identity=25.7971014492754, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=281, Percent_Identity=24.5551601423488, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=27.1255060728745, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=27.7533039647577, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081816, Length=313, Percent_Identity=25.5591054313099, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=253, Percent_Identity=23.3201581027668, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=233, Percent_Identity=29.1845493562232, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=21.6814159292035, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=27.3913043478261, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=23.3449477351916, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50559; Mature: 50559

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GGQPALNAMMADWPEADKKYFSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDK
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCCC
ENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGVLGGLFFSTLLAWNLTRPMRQ
CCCEEEEECCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSPLARLQLAIGLAHQNPDNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
DLQELVKVVVNDARYEAQLPGVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSAS
CHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
GQQVKVTLSALDKRYQIQVADQGPGVEENKLSSIFDPFVRVKSAMSGKGYGLGLAITHKV
CCEEEEEHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
ILAHGGQVEARNGEQGGLVITLRVPRWQA
HHCCCCEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MRGRLFWKILLGFWLTFILMTQMLWVIFSFYGHRHEPPENDLVRQIARLQVVSAASVLHT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GGQPALNAMMADWPEADKKYFSVLPAEMADTAEKDISALSGEEPKLYSSEIVTWVTAPDK
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCEEEEEECCCC
ENYRVSYDIEGLRAANLANAPDKHRREILNVPIPMIWMGVLGGLFFSTLLAWNLTRPMRQ
CCCEEEEECCCHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRVGFERVAQGDLSVRLLPVMRRRHDELTEVARDFDSMAERLQALVSAREQLLHDVSHEL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSPLARLQLAIGLAHQNPDNVDNALQRIEHESERLDKMIGELLALSRAENHSLADDDEYF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
DLQELVKVVVNDARYEAQLPGVEIQLEVAAQSEYTVKGNAELMRRAIENIVRNALRFSAS
CHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
GQQVKVTLSALDKRYQIQVADQGPGVEENKLSSIFDPFVRVKSAMSGKGYGLGLAITHKV
CCEEEEEHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
ILAHGGQVEARNGEQGGLVITLRVPRWQA
HHCCCCEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]