Click here to switch to the map view.

The map label for this gene is tibA [H]

Identifier: 22125243

GI number: 22125243

Start: 1488476

End: 1488775

Strand: Reverse

Name: tibA [H]

Synonym: y1344

Alternate gene names: 22125243

Gene position: 1488775-1488476 (Counterclockwise)

Preceding gene: 22125244

Following gene: 22125230

Centisome position: 32.36

GC content: 52.0

Gene sequence:

>300_bases
TTGAGCGCCTTTAGCTCGGGTAAAAGCGCGGTCAAACTGTCTAACGGCATGGTGGCGCAAAGCAGCAGCACCCGCTCGAT
GATAGGCACCCTTGGGGTGAATGCGGGTTACCGCTTCGTGCTGAAAAATGGCGTAGAAATGAAACCTTATGTCAGCGCCT
CGGTTGATCACGAATTTGCTGCCAATAATAAATTCAGAGTGAACCAGGAGATGTTCGATAACAACCTGAACGGCACGCGA
GTGAACACCGGTGCAGGCCTGAACGTCAACATCACCCCTAACCTGTCGGTTCTGAAGTGA

Upstream 100 bases:

>100_bases
AGCGCCAGCGGCAACACTAATTTCTCGGGTATGGGGGTGGCAGTGAAAGCCGGTAAGCATATCAACCATAATCATCTGTA
TGTTTCGCCATACGTGGCAA

Downstream 100 bases:

>100_bases
AGTTGTCCAGCGGAAAAAACATCAAAACGCCAGTGACCGTTAATCTGAACGTGGGTTATCGCTTCTAAGTGAATAAAATC
ATTTTTTAGAGATGACGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 99; Mature: 98

Protein sequence:

>99_residues
MSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFAANNKFRVNQEMFDNNLNGTR
VNTGAGLNVNITPNLSVLK

Sequences:

>Translated_99_residues
MSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFAANNKFRVNQEMFDNNLNGTR
VNTGAGLNVNITPNLSVLK
>Mature_98_residues
SAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFAANNKFRVNQEMFDNNLNGTRV
NTGAGLNVNITPNLSVLK

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 10560; Mature: 10429

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFA
CCCCCCCCCEEEECCCEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCEEECCCCCCCC
ANNKFRVNQEMFDNNLNGTRVNTGAGLNVNITPNLSVLK
CCCCEEECHHHHCCCCCCCEEECCCCEEEEECCCCEEEC
>Mature Secondary Structure 
SAFSSGKSAVKLSNGMVAQSSSTRSMIGTLGVNAGYRFVLKNGVEMKPYVSASVDHEFA
CCCCCCCCEEEECCCEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCEEECCCCCCCC
ANNKFRVNQEMFDNNLNGTRVNTGAGLNVNITPNLSVLK
CCCCEEECHHHHCCCCCCCEEECCCCEEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]