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The map label for this gene is pgm [H]

Identifier: 22125158

GI number: 22125158

Start: 1404611

End: 1406296

Strand: Direct

Name: pgm [H]

Synonym: y1258

Alternate gene names: 22125158

Gene position: 1404611-1406296 (Clockwise)

Preceding gene: 161484841

Following gene: 22125159

Centisome position: 30.53

GC content: 50.53

Gene sequence:

>1686_bases
ATGGCAACGCCCTTGCTGAGGACGTGTATAGGAGTAGTGACTGTGGCGAATCACCCTCGGGCTGGGCAACCTGCTCAGCA
AAGCGATTTAATTAACGTAGCTCAGTTGACATCGCAATATTATGTATTGCAGCCAGACGCTGAAGACCCCGCTCATGCCG
TTAAATTTGGTACTTCCGGCCACCGTGGTAGTTCAGTGCGCCACAGTTTTAATGAAGCTCATATTCTTGCTATCGCGCAG
GCGATAGCTGAAGTTCGTCATCAACACGGTATCAGCGGCCCATGCTATGTGGGTAAAGATACCCATGCGCTATCCGAGCC
CGCCTTTATTTCGGTGCTGGAAGTGTTGACGGCGAATGGTGTCGATGTTGTCGTACAGCAAGATAATGGTTTTACGCCAA
CACCGGCCATTTCCCATGTCATTCTTTGTCATAACGCCCAGGGTAAAGCGTTGGCGGATGGTATTGTCATTACGCCATCC
CACAACCCACCGGAAGACGGTGGCATTAAGTACAACCCGCCGAATGGTGGCCCAGCGGATACTAATCTGACGTCCGTGAT
TGAAAAGCGGGCTAATCAGTTACTCAGCCAGAATTTAAAGGGTGTTAAGCGCCAAACATTGGATAAAGCCTGGCAGAGCA
ATCATCTGCGTGAGCAGGATTTGCTCCAACCTTATGTTGAAGGTTTGGTGGATGTCGTTGATATTCCCGCCATTCAACAA
GCAGGGCTGAAGCTCGGTGTGGATCCGCTTGGCGGCTCCGGTATTGCCTACTGGCAGCGCATTGCTGAGTACTACAAGCT
GGATTTGACGTTGGTCAATAATGCCATCGATCAGACATTCCGATTTATGCATCTTGATCACGATGGTGTGATCCGCATGG
ATTGCTCTTCAGAGTCGGCGATGGCTGGTTTGTTGGCACTGCGCGATAAATTTGATTTAGCTTTTGCTAATGATCCAGAT
TACGACCGTCATGGCATTGTGACCCCAGCCGGGTTGATGAATCCGAATCATTATCTCGCGGTATCTATTAATTATCTGTT
CCAGCATCGCCCACAATGGGGGGCGGGGGTGGCAGTCGGTAAAACATTGGTTTCCAGTGCGATGATTGATCGGGTTGTGG
CTGATTTGGGCCGCAAGCTGGTGGAAGTCCCCGTTGGCTTTAAGTGGTTTGTTGATGGTTTACACGACGGCAGTTTTGGT
TTTGGTGGCGAAGAGAGTGCCGGGGCTTCTTTCCTGCGCTTTAATGGCACGCCGTGGTCGACCGATAAAGACGGCATTAT
CATGTGTCTGTTGGCGGCAGAAATTACGGCCGTGACCGGTAAGGACCCACAACGTCACTATGATGATTTAGCACAACGCT
TTGGTGCGCCAAGTTATAACCGTATTCAGGCGCCGGCAACGCAGGCGCAGAAAAATGCCTTGTCCAGATTGTCACCTGAA
ATGGTGAAAGCCAATACACTGGCGGGTGATCCGATCACTGCCCGTTTAACCAATGCCCCAGGGAATGGTGCATCAATTGG
TGGCTTGAAAGTGATGACTGAGAACGGCTGGTTTGCCGCTCGCCCATCAGGCACTGAAGAAGCGTACAAAATTTACTGTG
AAAGTTTCCTTGGCGCGGAGCATCGCGAAAAAATAGAACAAGAAGCCGTAAAGATTGTCAGCGAAGTGCTGGCTGAGGCG
AAATAA

Upstream 100 bases:

>100_bases
GGTACAGCACATCATGCTGGCAATGCAGTTCCCGCCGGAGTTGACTGACAAAGTGTGCGGAACTATCTGATTTCATTGAA
ACCATCCTCTTTCTCAGCCA

Downstream 100 bases:

>100_bases
GCGGGTATATTCCTGTCCTTAAAGACCAACGCTGTAATCTTGGCACTCGATCAATCCGGCACAGGCTCTGTTGCCGGATT
TTTTATGTGTTTTTCTTAAT

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MATPLLRTCIGVVTVANHPRAGQPAQQSDLINVAQLTSQYYVLQPDAEDPAHAVKFGTSGHRGSSVRHSFNEAHILAIAQ
AIAEVRHQHGISGPCYVGKDTHALSEPAFISVLEVLTANGVDVVVQQDNGFTPTPAISHVILCHNAQGKALADGIVITPS
HNPPEDGGIKYNPPNGGPADTNLTSVIEKRANQLLSQNLKGVKRQTLDKAWQSNHLREQDLLQPYVEGLVDVVDIPAIQQ
AGLKLGVDPLGGSGIAYWQRIAEYYKLDLTLVNNAIDQTFRFMHLDHDGVIRMDCSSESAMAGLLALRDKFDLAFANDPD
YDRHGIVTPAGLMNPNHYLAVSINYLFQHRPQWGAGVAVGKTLVSSAMIDRVVADLGRKLVEVPVGFKWFVDGLHDGSFG
FGGEESAGASFLRFNGTPWSTDKDGIIMCLLAAEITAVTGKDPQRHYDDLAQRFGAPSYNRIQAPATQAQKNALSRLSPE
MVKANTLAGDPITARLTNAPGNGASIGGLKVMTENGWFAARPSGTEEAYKIYCESFLGAEHREKIEQEAVKIVSEVLAEA
K

Sequences:

>Translated_561_residues
MATPLLRTCIGVVTVANHPRAGQPAQQSDLINVAQLTSQYYVLQPDAEDPAHAVKFGTSGHRGSSVRHSFNEAHILAIAQ
AIAEVRHQHGISGPCYVGKDTHALSEPAFISVLEVLTANGVDVVVQQDNGFTPTPAISHVILCHNAQGKALADGIVITPS
HNPPEDGGIKYNPPNGGPADTNLTSVIEKRANQLLSQNLKGVKRQTLDKAWQSNHLREQDLLQPYVEGLVDVVDIPAIQQ
AGLKLGVDPLGGSGIAYWQRIAEYYKLDLTLVNNAIDQTFRFMHLDHDGVIRMDCSSESAMAGLLALRDKFDLAFANDPD
YDRHGIVTPAGLMNPNHYLAVSINYLFQHRPQWGAGVAVGKTLVSSAMIDRVVADLGRKLVEVPVGFKWFVDGLHDGSFG
FGGEESAGASFLRFNGTPWSTDKDGIIMCLLAAEITAVTGKDPQRHYDDLAQRFGAPSYNRIQAPATQAQKNALSRLSPE
MVKANTLAGDPITARLTNAPGNGASIGGLKVMTENGWFAARPSGTEEAYKIYCESFLGAEHREKIEQEAVKIVSEVLAEA
K
>Mature_560_residues
ATPLLRTCIGVVTVANHPRAGQPAQQSDLINVAQLTSQYYVLQPDAEDPAHAVKFGTSGHRGSSVRHSFNEAHILAIAQA
IAEVRHQHGISGPCYVGKDTHALSEPAFISVLEVLTANGVDVVVQQDNGFTPTPAISHVILCHNAQGKALADGIVITPSH
NPPEDGGIKYNPPNGGPADTNLTSVIEKRANQLLSQNLKGVKRQTLDKAWQSNHLREQDLLQPYVEGLVDVVDIPAIQQA
GLKLGVDPLGGSGIAYWQRIAEYYKLDLTLVNNAIDQTFRFMHLDHDGVIRMDCSSESAMAGLLALRDKFDLAFANDPDY
DRHGIVTPAGLMNPNHYLAVSINYLFQHRPQWGAGVAVGKTLVSSAMIDRVVADLGRKLVEVPVGFKWFVDGLHDGSFGF
GGEESAGASFLRFNGTPWSTDKDGIIMCLLAAEITAVTGKDPQRHYDDLAQRFGAPSYNRIQAPATQAQKNALSRLSPEM
VKANTLAGDPITARLTNAPGNGASIGGLKVMTENGWFAARPSGTEEAYKIYCESFLGAEHREKIEQEAVKIVSEVLAEAK

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=449, Percent_Identity=25.8351893095768, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI21361621, Length=442, Percent_Identity=25.5656108597285, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI133922562, Length=407, Percent_Identity=25.3071253071253, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=82.7838827838828, Blast_Score=937, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322722, Length=559, Percent_Identity=26.654740608229, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323752, Length=560, Percent_Identity=23.75, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17864244, Length=425, Percent_Identity=27.7647058823529, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 60526; Mature: 60395

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPLLRTCIGVVTVANHPRAGQPAQQSDLINVAQLTSQYYVLQPDAEDPAHAVKFGTSG
CCCHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCHHHEECCCCC
HRGSSVRHSFNEAHILAIAQAIAEVRHQHGISGPCYVGKDTHALSEPAFISVLEVLTANG
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCC
VDVVVQQDNGFTPTPAISHVILCHNAQGKALADGIVITPSHNPPEDGGIKYNPPNGGPAD
CEEEEECCCCCCCCHHHCEEEEEECCCCCEEECCEEECCCCCCCCCCCEEECCCCCCCCC
TNLTSVIEKRANQLLSQNLKGVKRQTLDKAWQSNHLREQDLLQPYVEGLVDVVDIPAIQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHH
AGLKLGVDPLGGSGIAYWQRIAEYYKLDLTLVNNAIDQTFRFMHLDHDGVIRMDCSSESA
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCHH
MAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMNPNHYLAVSINYLFQHRPQWGAGVAVG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCHHCCCCCCEEEEEEEEHHHCCCCCCCCHHHH
KTLVSSAMIDRVVADLGRKLVEVPVGFKWFVDGLHDGSFGFGGEESAGASFLRFNGTPWS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCEEEEECCCCCC
TDKDGIIMCLLAAEITAVTGKDPQRHYDDLAQRFGAPSYNRIQAPATQAQKNALSRLSPE
CCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHH
MVKANTLAGDPITARLTNAPGNGASIGGLKVMTENGWFAARPSGTEEAYKIYCESFLGAE
HHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCH
HREKIEQEAVKIVSEVLAEAK
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATPLLRTCIGVVTVANHPRAGQPAQQSDLINVAQLTSQYYVLQPDAEDPAHAVKFGTSG
CCHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCHHHEECCCCC
HRGSSVRHSFNEAHILAIAQAIAEVRHQHGISGPCYVGKDTHALSEPAFISVLEVLTANG
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCC
VDVVVQQDNGFTPTPAISHVILCHNAQGKALADGIVITPSHNPPEDGGIKYNPPNGGPAD
CEEEEECCCCCCCCHHHCEEEEEECCCCCEEECCEEECCCCCCCCCCCEEECCCCCCCCC
TNLTSVIEKRANQLLSQNLKGVKRQTLDKAWQSNHLREQDLLQPYVEGLVDVVDIPAIQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHH
AGLKLGVDPLGGSGIAYWQRIAEYYKLDLTLVNNAIDQTFRFMHLDHDGVIRMDCSSESA
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCHH
MAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMNPNHYLAVSINYLFQHRPQWGAGVAVG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCHHCCCCCCEEEEEEEEHHHCCCCCCCCHHHH
KTLVSSAMIDRVVADLGRKLVEVPVGFKWFVDGLHDGSFGFGGEESAGASFLRFNGTPWS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCEEEEECCCCCC
TDKDGIIMCLLAAEITAVTGKDPQRHYDDLAQRFGAPSYNRIQAPATQAQKNALSRLSPE
CCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHH
MVKANTLAGDPITARLTNAPGNGASIGGLKVMTENGWFAARPSGTEEAYKIYCESFLGAE
HHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCH
HREKIEQEAVKIVSEVLAEAK
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]