| Definition | Yersinia pestis KIM 10 chromosome, complete genome. |
|---|---|
| Accession | NC_004088 |
| Length | 4,600,755 |
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The map label for this gene is pbpC [H]
Identifier: 22125045
GI number: 22125045
Start: 1281055
End: 1283592
Strand: Reverse
Name: pbpC [H]
Synonym: y1141
Alternate gene names: 22125045
Gene position: 1283592-1281055 (Counterclockwise)
Preceding gene: 22125047
Following gene: 22125043
Centisome position: 27.9
GC content: 52.4
Gene sequence:
>2538_bases TTGTTGAACATTTGCAGTTGCCAGACCGCAAACTGTTTTAACAAATCAAAAGGGGTTTTTATAACTGACCCAAAGCTGAA AGCTTTACTGAACCCCCAGCCTAGCTGGGGGTTTTCTGGGCACAACAACGCGCCCCGCATCGCCGGGGCGCTATCGGATT TCAGCCGTAACCAGATGCGCATCCCAACCTTAATGGCAACCAAACGCCTGTTGCAAAATATCCTGATGGCCCTCTTTCTG TTGGCCCTCTTGGTCATCGGCTTTCGGCTGTGGCCACACCCGCCCTTGTCTCAGGGGCTCCCACTCTCTACGGCTTACTA TGATCGGCACGGCACGCTATTACGTCTTTCGCTGGCTAATGATGATCGTTATCGCCTGTGGACACCGTTGGAAGAGATCT CCCCATTGGTGATACAGGGTATCCAACTGCATGAAGACCGCGGTTTCTATTATCATCCCGGTGTTAATCCCATTAGCCTG TTACGCGGGTTCTGGCAAAGCTATGTACAAGGCGGCAGGCAACAGGGCGGTTCAACCCTGACCATGCAGTTGGCACGGAT GCACTGGCATCTCAATACCCGTTCGCCAACAGGTAAATTGCGACAAATCGCCCGAGCTATCCAACTGGAACTGAGCTATT CCAAGCACGATATTTTAGAGGCTTACCTGAATTACGCCCCTTATGGCCGTAATATCGAAAGTATTGCCGCTGCCAGCCTG ATTTATTTTGATAAAAAACCCCAGCAACTGACGCTGCCAGAAGCCCTGACATTGGCGGTATTGCCCCAATCGCCCAGTTA CCGCATTGATCCCACCACCGGTGTGCTGGGGAGCGCCCTGACCCAAGCCCGTAACCGGCTATTCGTTCGCTGGCAACAAA CGTACCCCACCGATAGCAGCCAAATGGCGCTATTCCAGTTACCGCTCAGCCTGCGTCAACCCGAAAAAATGCCCTATATC GCGCCACATTTTATTGAACAGATCCGGCGGCAAAATCAACAACTGGCGAATACCCAGAGTCAGGTTGACACCACACTGGA TGCCAATCTGCAACAACTGGTAGAAAAACAGGTCGAGGCCTTTATCCGCCGTAATAACAGCCGGGGTATCCATAATGCGG CGGTATTATTGCTGGATACACGGGATATGGGCGTTCGGGCGCTGGTGGGGTCGGCAAATTATTATGACCGAGAAATTCAG GGGCAAGTTAACGGCACCAATGCCAAACGCTCCCCCGGTTCGACACTGAAACCCTTTATTTATGCTCTAGGGCTAGAACA GGGGATACTGCATCCGATGACCATCCTGAAAGATGTGCCCTCTTCTTTCGGGGCCTATGCGCCAGAGAATTTTGACCACC GTTTTCTGGGGCCAGTGACCGCCACGGACGCCTTGAATTTCAGCCGAAACATTCCTGCGGTGTATGTCGCATCCCGTTTA AGACAACCAACGCTATACCAATTTTTACGTTTATCCGGTGTTACCAATATGGCCAGTGAAAACCATTACGGTTTATCACT GGTGCTGGGGGGCGGTGAAATTACCCTACAGGAGCTGGCGCGGCTCTATGCCATGTTGGCGAATCGCGGCACACTGCACC CCATACAAATGGTACAAACAGATAAAACGCTGCCCTCCATTCGTCTGTTAAGCGAGGCGGCCAGTTTCATCACGCTTGAT ATGTTGCGTCAGCACCGCCGCCCCGGTGATACCTTGGCACAAAGCCCCACCTCGCTACCGGTCTACTGGAAAACCGGGAC CTCTTGGGGATTCAGAGATGCCTGGAGCGCAGGGATTTTTGGCCCTTATGTGTTAATCGTCTGGGAAGGCAACTTTGCGG GTAAGGGCAACAGCGCCTTTGTCGGTGCCGATGCCGCCGCACCGTTATTCTTTAATATTATTGACAGTATTCAGGCTAAC TACCCAGCGCTGCGCGAGCCTAAACATCCTTGGCCGCCACAGTTAAAACGGGTGGCTATCTGTCTGGCCAGCGGCAACTT GCCCACGCCTTGGTGTCAGCAGCAAGGTAAAACCTGGTTTATTCCGGGGAAATCGCCGATCAAAGTCGATACGGTCTATC GCCCCGTCGTGATTGATATAAATAGTGGTCAGGCCGCTTGTCTACCTTATGACCGCAGCCAGACCCGTACTGAAGTTTTT GAGTTCTGGCCATCGGATCTGGCCAATGTATTTGCTCAAGCGGGCTTGCCGAAACGCCAACCACCTGACCGCTCTCACTG CAAAGAAGGGAATACTCTCGCATCGGGTAATGCACCACGTATCACCTCACCGCTGCGCAATACCACCTACACCCTGCGCC AATCACAACAGGGCCGTGATCAGATTGTATTCAGCGCCACTCTTGATGCGGATAGCACCACCACTTACTGGTTTGTTGAC GATATCTATCTAGGCAGCAGCACCAGTAAAAAATCCATCGATTGGCATCCGACCCGCAGCGGTCAATACCGCATTCGGGC AATTGATGATCATGGCCGCGCTGATAGTAGGCTAATTCGTGTTGAGAAAGTGGATTAA
Upstream 100 bases:
>100_bases TGCCTTCGGTACTTCGGCGCAAAAACTATATGATATTTACAGTTCCATCGGGTGTGCGCTAAGCTCTTTTCATCCCTCAT TGGGACCCCCTTTTGATTTC
Downstream 100 bases:
>100_bases TGGCACACCTTACGGTTTCCATCCTTAGAGCGCCTGCTGTGCTTCTACGGGGTAATATATTGATATTGGTCAACGAGATG AGTAACCAGCAAACGGCCGG
Product: penicillin-binding protein
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 845; Mature: 845
Protein sequence:
>845_residues MLNICSCQTANCFNKSKGVFITDPKLKALLNPQPSWGFSGHNNAPRIAGALSDFSRNQMRIPTLMATKRLLQNILMALFL LALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLANDDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISL LRGFWQSYVQGGRQQGGSTLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAASL IYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTDSSQMALFQLPLSLRQPEKMPYI APHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEAFIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQ GQVNGTNAKRSPGSTLKPFIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVASRL RQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMVQTDKTLPSIRLLSEAASFITLD MLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIFGPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQAN YPALREPKHPWPPQLKRVAICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTEVF EFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQGRDQIVFSATLDADSTTTYWFVD DIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIRVEKVD
Sequences:
>Translated_845_residues MLNICSCQTANCFNKSKGVFITDPKLKALLNPQPSWGFSGHNNAPRIAGALSDFSRNQMRIPTLMATKRLLQNILMALFL LALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLANDDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISL LRGFWQSYVQGGRQQGGSTLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAASL IYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTDSSQMALFQLPLSLRQPEKMPYI APHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEAFIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQ GQVNGTNAKRSPGSTLKPFIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVASRL RQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMVQTDKTLPSIRLLSEAASFITLD MLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIFGPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQAN YPALREPKHPWPPQLKRVAICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTEVF EFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQGRDQIVFSATLDADSTTTYWFVD DIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIRVEKVD >Mature_845_residues MLNICSCQTANCFNKSKGVFITDPKLKALLNPQPSWGFSGHNNAPRIAGALSDFSRNQMRIPTLMATKRLLQNILMALFL LALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLANDDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISL LRGFWQSYVQGGRQQGGSTLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAASL IYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTDSSQMALFQLPLSLRQPEKMPYI APHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEAFIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQ GQVNGTNAKRSPGSTLKPFIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVASRL RQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMVQTDKTLPSIRLLSEAASFITLD MLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIFGPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQAN YPALREPKHPWPPQLKRVAICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTEVF EFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQGRDQIVFSATLDADSTTTYWFVD DIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIRVEKVD
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=804, Percent_Identity=32.089552238806, Blast_Score=320, Evalue=2e-88, Organism=Escherichia coli, GI1786343, Length=523, Percent_Identity=26.7686424474187, Blast_Score=112, Evalue=7e-26, Organism=Escherichia coli, GI87082258, Length=256, Percent_Identity=28.125, Blast_Score=96, Evalue=1e-20, Organism=Escherichia coli, GI1789601, Length=228, Percent_Identity=27.6315789473684, Blast_Score=68, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 94698; Mature: 94698
Theoretical pI: Translated: 9.95; Mature: 9.95
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNICSCQTANCFNKSKGVFITDPKLKALLNPQPSWGFSGHNNAPRIAGALSDFSRNQMR CCCCCCCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE IPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLAN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECC DDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGSTL CCCEEEECCHHHCCHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHH TMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAASL HHEEEHHHEEECCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHH IYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTDSS EEECCCCCEEECCCEEEEEEECCCCCEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCC QMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEA CEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH FIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKPFI HHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCCHHHHH YALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVASRL HHHHHHCCCHHHHHHHHHCHHHHCCCCCCCCCCCEECCCHHHHHCCCCCCCCHHHHHHHC RQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMVQT CCHHHHHHHHHHCCHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCHHHEEEC DKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIF CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCCCCHHCCCCCC GPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRVAI CCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEE CLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTEVF EEECCCCCCHHHHHCCCEEEECCCCCEEEEEEECEEEEEECCCCEEEECCCCCHHHHHHH EFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQGRD HHCHHHHHHHHHHCCCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCEEEEHHCCCCCC QIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIR EEEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEE VEKVD EEECC >Mature Secondary Structure MLNICSCQTANCFNKSKGVFITDPKLKALLNPQPSWGFSGHNNAPRIAGALSDFSRNQMR CCCCCCCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEE IPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLAN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECC DDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGSTL CCCEEEECCHHHCCHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHH TMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAASL HHEEEHHHEEECCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHH IYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTDSS EEECCCCCEEECCCEEEEEEECCCCCEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCC QMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEA CEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH FIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKPFI HHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCCHHHHH YALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVASRL HHHHHHCCCHHHHHHHHHCHHHHCCCCCCCCCCCEECCCHHHHHCCCCCCCCHHHHHHHC RQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMVQT CCHHHHHHHHHHCCHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCHHHEEEC DKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIF CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCCCCHHCCCCCC GPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRVAI CCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEE CLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTEVF EEECCCCCCHHHHHCCCEEEECCCCCEEEEEEECEEEEEECCCCEEEECCCCCHHHHHHH EFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQGRD HHCHHHHHHHHHHCCCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCEEEEHHCCCCCC QIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIR EEEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEE VEKVD EEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]