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The map label for this gene is tesB [H]

Identifier: 22124950

GI number: 22124950

Start: 1176759

End: 1177646

Strand: Reverse

Name: tesB [H]

Synonym: y1043

Alternate gene names: 22124950

Gene position: 1177646-1176759 (Counterclockwise)

Preceding gene: 22124952

Following gene: 22124944

Centisome position: 25.6

GC content: 48.99

Gene sequence:

>888_bases
ATGAACTCAACCATCAGGGGCGACAACATGAGTCAGGCATTAGAAAAACTGCTCGATCTGCTCGATCTAGAGAAAATTGA
AGAAGGCATTTTCCGTGGACAAAGCGAAGATCTAGGTTTGCGGCAGGTATTTGGTGGTCAGGTTGTTGGTCAGGCGATTT
ATGCTGCGAAACAAACCGTCCCCGCAGAACGGACTGTTCACTCATTTCATAGCTATTTTCTGCGCCCTGGAGACAGCAGT
AAACCCATTATTTATGACGTAGAAACACTGCGTGATGGCAACAGTTTCAGCGCCCGCCGGGTCAGTGCGATTCAAAATGG
TAAGCCTATCTTTTATATGACGGCCTCGTTCCAGAGTCAGGAAGAAGGGTTTGAGCACCAAAATACAATGCCAGACGTCC
CACCACCAGAAGGGTTAATGTCCGAAACGGATATTGCCCGCCAGTTTTCACACTTGATCCCCGAGAAAGTGCGAGAAAAG
TTTATTGGCCCACAACCCATTGAAATGCGTCCGGTAAAATTCCACAACCCGCTGCAAGGCAGTGTAGAAGAACCCAATCG
CTATGTTTGGTTCCGCGCTAATGGCAAAATGCCAGATGACCTACGGGTTCATCAATATTTACTGGGTTATGCCTCGGACT
TTAATTTCCTGCCCACGGCTTTACAACCGCACGGCATTGGTTTCCTTGAACCCGGTATGCAAATCGCCACTATCGACCAC
TCGATGTGGTTCCATCGGCCATTCCGTTTGGATGACTGGTTACTCTATGCCGTAGAAAGTACTTCTGCGTCAGGTGCCCG
TGGCTTCGTTCGAGGGCAAATCTATAACCGGGAAGGGGTGCTGGTAGCTTCTACTGTGCAGGAGGGTGTGATTCGTTTAC
ATCGTTGA

Upstream 100 bases:

>100_bases
GATGTATTCAGCAGATCACTTCCCACGATTAATTCATCACTTGAGTAATGGTTTCACGGCAATATATTGACGACTGGCGG
GTTGATTCAGCACACTGTGT

Downstream 100 bases:

>100_bases
TACGGGGGTACAGATCAGCGTGACGTTATCTCAACCAGTTGATGAATCAATGAAATAGCACAGGGGCGATGTCACCATCG
CCCCCTGTAGTTCATCATTA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNSTIRGDNMSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSS
KPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREK
FIGPQPIEMRPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDH
SMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLHR

Sequences:

>Translated_295_residues
MNSTIRGDNMSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSS
KPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREK
FIGPQPIEMRPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDH
SMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLHR
>Mature_295_residues
MNSTIRGDNMSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSS
KPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREK
FIGPQPIEMRPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDH
SMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLHR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=41.6666666666667, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1786657, Length=285, Percent_Identity=78.9473684210526, Blast_Score=462, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=35.4948805460751, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=319, Percent_Identity=35.423197492163, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17531889, Length=312, Percent_Identity=33.974358974359, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI115532456, Length=312, Percent_Identity=33.974358974359, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=312, Percent_Identity=33.974358974359, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71982224, Length=295, Percent_Identity=31.864406779661, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI212645202, Length=290, Percent_Identity=32.0689655172414, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=122, Percent_Identity=34.4262295081967, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33452; Mature: 33452

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTIRGDNMSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHCC
PAERTVHSFHSYFLRPGDSSKPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQ
CHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCH
EEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEMRPVKFHNPLQG
HHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEECCEECCCCCCC
SVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDH
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEEC
SMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLHR
HHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEHHHHHHHHCCCC
>Mature Secondary Structure
MNSTIRGDNMSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHCC
PAERTVHSFHSYFLRPGDSSKPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQ
CHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCH
EEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEMRPVKFHNPLQG
HHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEECCEECCCCCCC
SVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDH
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEEC
SMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLHR
HHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]