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The map label for this gene is fhuD [H]

Identifier: 22124710

GI number: 22124710

Start: 891271

End: 892359

Strand: Direct

Name: fhuD [H]

Synonym: y0797

Alternate gene names: 22124710

Gene position: 891271-892359 (Clockwise)

Preceding gene: 22124709

Following gene: 161484863

Centisome position: 19.37

GC content: 50.41

Gene sequence:

>1089_bases
ATGAAGACACATTTACCCATGGATCTCTCTTCTTCATCGGCTTCGAATTATTTATCGGGTCCAGATTGCTCATCGGATCC
AGATTGTTCAGTAAGGCCAGCTTGTTCAGCAAGGTCAGATCGTTCAGTAAGGCCAGATCGTTCATCGGGGCCCGATTATT
ACCGGCGTCGGCTACTGATGGCATTAACGTTATCGCCATTACTGCTCTCATTGCCCAGTCTGGTAGCGGCGGCACCGAAG
AGCGATCAGCCATTACTCAATATAGACAGAGTGATTGATATCCAAAGAGATATCGATACTAAAAGGGTCGTCGCACTGGA
GTGGCTACCTGTCGAATTGCTACTGGCATTGGGGGTTACACCGTTTGGTGTCGCTGATATTCATAACTATCGCCTATGGG
TTGGGGAGCCTGCTCTGCCGGCGGATGTGATTAATGTCGGTCAGCGCACTGAACCCAATCTGGAATTACTGCAACAAATG
GCTCCATCGCTGATCCTGCTGTCGCAGGGTTATGGCCCTTCGCCGGAGAAACTTGCGCCTATCGCGCCCACGATGAGTTT
TGCGTTTAATGAACAGGGCAGTTCACCGCTGGCTGTAGGCAAAAACTCATTACAGACATTGGGGCAGCGTTTGGGATTGG
AGACGGCTGCGCAACAGCATCTTGCTGATTTTGACCATTTTATGCTGGCAGCCCGTGCGCGTTTATCTGGCGACACGCAG
ACTCCGTTATTAATGTTCTCTCTGTTGGATCCCCGCCATGCGTTGATTATCGGTAACGGCAGCCTGTTTCAGGATGTATT
GAGCACCTTGAATATTGAGAATGCCTGGCAAGGGGAGACCAATTTTTGGGGCAGCGCGGTGGTGGGTATTGAACGTTTAG
CGACGATAAAAACGGCACGTGCAGTGTGTTTCGGCCATGGAAATAATGAGATGTTACAGCAGGTTGCACGTACCCCATTA
TGGCAATCGCTGTCTTTTGTACGAGAAAACCAATTACGTCTCTTGCCACCGGTTTGGTTCTACGGCGCGACACTGTCAGC
TATGCGTTTCGTTCGTTTACTGGAACAGGCGTGGGGGAAAGCACCATGA

Upstream 100 bases:

>100_bases
ATAGCCTGATGCAGAGTGCGGTGTTAGAACAAATTTATGGTATCCCAATGGGTATTTTACCGCACCCGGCTGGCGGTGCG
CCGGTAAGTTTTGTTTATTA

Downstream 100 bases:

>100_bases
GCGCCATAAGTTTACGCCAGGGTTGGCGGCTCCCTGCGGGTCTACTTGGCCTACTGGTGGTTATTGCCGTTTCCCTGACA
TTTTATAACCTCAGTCAATT

Product: iron-hydroxamate transporter substrate-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSARSDRSVRPDRSSGPDYYRRRLLMALTLSPLLLSLPSLVAAAPK
SDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQM
APSLILLSQGYGPSPEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQ
TPLLMFSLLDPRHALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEMLQQVARTPL
WQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGKAP

Sequences:

>Translated_362_residues
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSARSDRSVRPDRSSGPDYYRRRLLMALTLSPLLLSLPSLVAAAPK
SDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQM
APSLILLSQGYGPSPEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQ
TPLLMFSLLDPRHALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEMLQQVARTPL
WQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGKAP
>Mature_362_residues
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSARSDRSVRPDRSSGPDYYRRRLLMALTLSPLLLSLPSLVAAAPK
SDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQM
APSLILLSQGYGPSPEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQ
TPLLMFSLLDPRHALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEMLQQVARTPL
WQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGKAP

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=305, Percent_Identity=51.4754098360656, Blast_Score=305, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 39717; Mature: 39717

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSARSDRSVRPDRSSGPDYYRRRLLM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ALTLSPLLLSLPSLVAAAPKSDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVT
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCC
PFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYGPSPEKLAP
CCCHHHCCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCC
IAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQ
CCCHHHHHCCCCCCCCHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPLLMFSLLDPRHALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTAR
CHHHHEECCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVCFGHGNNEMLQQVARTPLWQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGK
HHEEECCCHHHHHHHHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC
AP
CC
>Mature Secondary Structure
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSARSDRSVRPDRSSGPDYYRRRLLM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ALTLSPLLLSLPSLVAAAPKSDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVT
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCC
PFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYGPSPEKLAP
CCCHHHCCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCC
IAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQ
CCCHHHHHCCCCCCCCHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPLLMFSLLDPRHALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTAR
CHHHHEECCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVCFGHGNNEMLQQVARTPLWQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGK
HHEEECCCHHHHHHHHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]