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The map label for this gene is aroP [H]

Identifier: 22124678

GI number: 22124678

Start: 852372

End: 853772

Strand: Reverse

Name: aroP [H]

Synonym: y0765

Alternate gene names: 22124678

Gene position: 853772-852372 (Counterclockwise)

Preceding gene: 22124686

Following gene: 161484872

Centisome position: 18.56

GC content: 48.39

Gene sequence:

>1401_bases
TTGATGAGTGATCAACAAGAGGGTGCTGAGCTAAAACGGGGGCTTAAAAACCGCCATATTCAGCTTATTGCCCTAGGTGG
TGCAATTGGTACCGGACTATTCCTCGGCATAGCACAGACCATCAAAATGGCTGGGCCTTCGGTTTTACTGGGGTACGCAA
TTGGGGGTTTTATTGCGTTTCTGATAATGCGCCAGCTAGGCGAAATGGTGGTTGAAGAACCTGTAGCCGGTTCCTTTAGC
CACTTTGCGTATAAATATTGGGGACACTTTGCCGGTTTTGCTTCTGGCTGGAACTACTGGGTGCTGTATGTGTTGGTGGC
GATGGCCGAACTAACCGCAGTGGGGATCTATGTGCAATATTGGTGGCCAGAAATCCCTACCTGGGTCTCCGCCGCCGTCT
TCTTCTTGGCCATCAACGCCATCAACCTGGCTAACGTAAAAGTCTATGGTGAGATGGAATTTTGGTTTGCCATCATTAAA
GTGATCGCGATTATTGCGATGATTTTATTTGGCGGTTACCTGCTCATCAGTGGCCGGGGTGGCCCAGAAGCCACGGTAAC
CAACTTATGGGCCCAAGGCGGTTTCTTCCCGAATGGCATCATGGGTCTGGTGATGGCAATGGCGGTAATTATGTTCTCTT
TCGGTGGCCTTGAATTAGTGGGTATCACCGCAGCAGAAGCAGAAGACCCGGCCAAAAGCATTCCGAAGGCAACCAATCAG
GTTATCTACCGTATTCTTCTGTTTTATATTGGTTCTCTGGCAATCTTGTTATCACTCTACCCATGGGGAAAAGTGGTCGA
AGGCGGCAGCCCATTCGTATTGATTTTCGATGCGCTGGACAGTAATTCAGTCGCCACTGTCTTGAATATTGTCGTACTGA
CGGCGGCACTCTCGGTCTACAACAGTTGCGTATACTGTAACAGCCGCATGTTGTTTGGTTTAGCTAAACAAGGTAATGGC
CCGAAAATCCTGTTGAAAGTGGATGGCCGAGGTGTTCCAGTCATTGCGATTGCTGTTTCTGCGTTTGCTACCGCGTTTTG
TGTACTGATTAACTACCTGTTACCTGGCCGTGCCTTTGAATTACTGATGGCATTAGTGGTATCCGCGTTGGTGATCAACT
GGGCGATGATTAGCCTGGCACACCTGAAATTCCGTGCGGCGAAAAACCGCCAGGGCGTAATACCAAAATTCAAAGCATTT
TGGTATCCGTTCGGTAACTGTTTGTGTTTGTTGTTCCTGACCGGCATCTTAGTGATCATGTTTCTGACACCCAGCATCCG
GATTTCAGTGATACTTATTCCTGTCTGGGTAGTCGTCCTAGCGATTGGTTATATTCTGAAGAATCAGAGCCAACGTCAGA
ATCAGCAACTGAGCGCTAGCAGCAGGAAAGTAACCAAGTAA

Upstream 100 bases:

>100_bases
CGAATGAATATCGCTAGCGTCTCTGTAACGTCCAATGATGAAGGGTATAGCAAAAAACTAAGATTAAGCCCGCGAGTAGT
CACAACGACAAAGGATGTAA

Downstream 100 bases:

>100_bases
AGAACAACCCATTTCCTTATAAATCCGCTAGTTAACCCTACCTAGGCCAGCACTTAGTGCTGGCCTAGGCTATTGACAAA
GTACCTATGGCGAAGAGAAC

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MMSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIK
VIAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQ
VIYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNG
PKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAF
WYPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKVTK

Sequences:

>Translated_466_residues
MMSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIK
VIAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQ
VIYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNG
PKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAF
WYPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKVTK
>Mature_466_residues
MMSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIK
VIAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQ
VIYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNG
PKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAF
WYPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKVTK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=284, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI258645169, Length=368, Percent_Identity=22.0108695652174, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786302, Length=452, Percent_Identity=76.1061946902655, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=442, Percent_Identity=66.5158371040724, Blast_Score=593, Evalue=1e-170,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=46.1368653421634, Blast_Score=354, Evalue=8e-99,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=41.3394919168591, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1790653, Length=461, Percent_Identity=38.6117136659436, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI87081915, Length=449, Percent_Identity=37.1937639198218, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=36.405529953917, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI87081708, Length=471, Percent_Identity=34.3949044585987, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788480, Length=444, Percent_Identity=35.1351351351351, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=35.6347438752784, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=436, Percent_Identity=34.4036697247706, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322892, Length=398, Percent_Identity=35.427135678392, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=487, Percent_Identity=31.211498973306, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=33.0788804071247, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=33.4085778781038, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6319824, Length=404, Percent_Identity=31.6831683168317, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=423, Percent_Identity=31.9148936170213, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=408, Percent_Identity=29.656862745098, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=445, Percent_Identity=30.1123595505618, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=441, Percent_Identity=28.1179138321995, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=28.8177339901478, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=28.8557213930348, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=30, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=396, Percent_Identity=29.040404040404, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319542, Length=412, Percent_Identity=28.8834951456311, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.030303030303, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=479, Percent_Identity=25.678496868476, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24667468, Length=373, Percent_Identity=24.1286863270777, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668806, Length=379, Percent_Identity=24.0105540897098, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356285, Length=379, Percent_Identity=24.0105540897098, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24668802, Length=379, Percent_Identity=24.0105540897098, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666159, Length=288, Percent_Identity=23.6111111111111, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221512776, Length=344, Percent_Identity=22.3837209302326, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50741; Mature: 50741

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAF
CCCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LIMRQLGEMVVEEPVAGSFSHFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEE
WWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVIAIIAMILFGGYLLISGRG
ECCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHH
VIYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVY
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
NSCVYCNSRMLFGLAKQGNGPKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFE
HHHHEECCHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWYPFGNCLCLLFLTGILVIM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
FLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKVTK
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAF
CCCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LIMRQLGEMVVEEPVAGSFSHFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEE
WWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVIAIIAMILFGGYLLISGRG
ECCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAEDPAKSIPKATNQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHH
VIYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVY
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
NSCVYCNSRMLFGLAKQGNGPKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFE
HHHHEECCHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWYPFGNCLCLLFLTGILVIM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
FLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKVTK
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]