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The map label for this gene is guaC [H]

Identifier: 22124671

GI number: 22124671

Start: 844287

End: 845330

Strand: Direct

Name: guaC [H]

Synonym: y0758

Alternate gene names: 22124671

Gene position: 844287-845330 (Clockwise)

Preceding gene: 22124667

Following gene: 22124676

Centisome position: 18.35

GC content: 47.13

Gene sequence:

>1044_bases
ATGCGCATTGAAGAAGGTTTGAAATTAGGCTTTAAGGATGTGTTAATCCGTCCTAAACGTTCAACGCTGAAAAGCCGTTC
TGAAGTTGCTCTGGAACGTCAGTTTACTTTCAAACATTCAGGTTGGAATTGGTCTGGTGTCCCTATCATAGCCGCTAATA
TGGATACCGTTGGTACCTTCCGCATGGCTGAGGTTTTGGCTTCATTTGATATTCTTACTGCCGTTCACAAGCATTACACT
CTCGAACAATGGGCTGAGTTCGTTAAGCGCTCACCAGAATCAGTGTTACTCCATGTCATGGTATCAACGGGCACTTCCTC
TGCTGATTTCGACAAAATGAAACAAATTTTGGCGTTATCACCATCATTAAAATTTATCTGTATTGATGTCGCGAACGGCT
ACTCAGAACACTTTGTTTCTTTCCTGCAAAGAGCGCGTGAAGCTTGTCCTGATAAAGTCATTTGTGCGGGTAATGTCGTG
ACAGGTGAAATGGTAGAGGAACTGATCCTCTCTGGTGCTGATATCGTTAAAGTCGGTATTGGCCCTGGTTCTGTTTGTAC
CACCCGTGTTAAGACTGGCGTTGGCTACCCACAACTGTCTGCTGTCATTGAGTGCGCCGACGCTGCTCATGGCCTTGGGG
GCCAAATTGTCAGCGATGGTGGCTGTTCTGTTCCAGGTGATGTGGCTAAAGCTTTTGGTGGTGGTGCCGATTTCGTGATG
CTAGGTGGCATGTTGGCAGGCCATGATGAGTGTGAAGGGCGCGTTGTCGAAGAGAATGGCGAGAAGTTCATGCTGTTTTA
CGGGATGAGTTCTGAATCTGCGATGAAACGCCATGTCGGTGGTGTTGCACAATACCGTGCGGCAGAAGGTAAAACGGTTA
AGTTACCACTGCGTGGTTCAGTCGATAATACCGTGCGTGACATCATGGGAGGCCTACGTTCTGCATGTACTTATGTGGGC
GCTTCACATTTGAAAGAATTAACGAAGCGTACGACGTTTATTCGCGTAGCAGAGCAAGAAAACCGCGTATTTGGCACTGA
TTGA

Upstream 100 bases:

>100_bases
CGAAGAATTATTCATGCGTATGATAGCTCCACTGGGATGGCGTGTTTTACGCCCGATCACATTTTGCGATCTATCGCCAA
TAACCAGGGAATAATAAGTC

Downstream 100 bases:

>100_bases
TACGGGTTATTACGGCATGATAATTTGTCAGTAATGTCGTCATCAGGATACCTGAGCGCTGAGTTGTAGGGTGCCAACGC
AATTCAATATAGGGTTGTGT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYT
LEQWAEFVKRSPESVLLHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVG
ASHLKELTKRTTFIRVAEQENRVFGTD

Sequences:

>Translated_347_residues
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYT
LEQWAEFVKRSPESVLLHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVG
ASHLKELTKRTTFIRVAEQENRVFGTD
>Mature_347_residues
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYT
LEQWAEFVKRSPESVLLHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVG
ASHLKELTKRTTFIRVAEQENRVFGTD

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=343, Percent_Identity=68.2215743440233, Blast_Score=496, Evalue=1e-141,
Organism=Homo sapiens, GI50541952, Length=343, Percent_Identity=68.2215743440233, Blast_Score=496, Evalue=1e-141,
Organism=Homo sapiens, GI50541948, Length=343, Percent_Identity=68.2215743440233, Blast_Score=496, Evalue=1e-141,
Organism=Homo sapiens, GI50541956, Length=342, Percent_Identity=68.4210526315789, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=66.7638483965015, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI66933016, Length=224, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI217035150, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI217035146, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI217035152, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI217035148, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI34328930, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI34328928, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156616279, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=85.1744186046512, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1788855, Length=222, Percent_Identity=35.5855855855856, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=63.265306122449, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71994385, Length=214, Percent_Identity=32.2429906542056, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71994389, Length=165, Percent_Identity=36.969696969697, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322012, Length=257, Percent_Identity=29.1828793774319, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=30.6382978723404, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323464, Length=230, Percent_Identity=30.4347826086957, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=35, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641071, Length=241, Percent_Identity=29.4605809128631, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24641073, Length=241, Percent_Identity=29.4605809128631, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571163, Length=241, Percent_Identity=29.4605809128631, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37450; Mature: 37450

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTF
CCCCHHHCCCHHHHEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCHHHH
RMAEVLASFDILTAVHKHYTLEQWAEFVKRSPESVLLHVMVSTGTSSADFDKMKQILALS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCC
PSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGS
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VDNTVRDIMGGLRSACTYVGASHLKELTKRTTFIRVAEQENRVFGTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure
MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTF
CCCCHHHCCCHHHHEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEECCCCHHHH
RMAEVLASFDILTAVHKHYTLEQWAEFVKRSPESVLLHVMVSTGTSSADFDKMKQILALS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCC
PSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGS
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VDNTVRDIMGGLRSACTYVGASHLKELTKRTTFIRVAEQENRVFGTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA