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The map label for this gene is wecB [H]

Identifier: 22124279

GI number: 22124279

Start: 406882

End: 408066

Strand: Direct

Name: wecB [H]

Synonym: y0364

Alternate gene names: 22124279

Gene position: 406882-408066 (Clockwise)

Preceding gene: 161484903

Following gene: 22124280

Centisome position: 8.84

GC content: 50.3

Gene sequence:

>1185_bases
GTGCGCCCAACTTGCAGGCATTGCCTGCGGCTAACTGACCTAAAGAGATTCACTGTGAAAGTGTTGACTGTTTTTGGCAC
CCGTCCTGAAGCGATAAAGATGGCTCCTCTGGTGCATGCCTTGGCTCAGGATGACGCCTTTGAATCGAGAGTCTGCGTAA
CGGCCCAGCATCGTGAGATGCTGGATCAGGTATTGCGTTTATTTGAGATTCAACCAGATTATGATTTAGACATCATGAGG
CCAGGACAGGGATTGACGGAAATAACCTGCCGCATTCTGGAAGGGCTAAAGCCGGTTCTCGAAGAGTTTAAGCCGGATGT
TATCTTGGTGCATGGCGATACCACAACCACACTGTCGGCCAGTCTGGCCGGGTTCTATCACCGCATACCTGTCGGCCATG
TCGAGGCTGGGCTGCGGACCGGGGATCTCTATTCTCCATGGCCGGAGGAAGCTAACCGTCAACTGACTGGGCATCTTGCC
ATGTATCATTTTGCGCCGACCGAGAATTCTCGACAGAATTTGCTACGTGAATGGGTGCCGGAGAACCGTATTTTTGTCAC
GGGTAATACGGTGATTGATGCGTTGTTCTGGGTCCGTGATCGGGTGATGAATACCCCTGATTTGCGAGCAAACTTGGCAC
AACGTTACGCCTTCCTTGATACCAATAAGAAGATGATTCTGGTTACTGGCCATCGTCGTGAAAGCTTTGGTGGTGGTTTT
GAGCGGATTTGCAGTGCGTTAGCGGAAATTGCCCGGAAACATCCCGAGGTGCAGGTTGTTTATCCCGTGCATCTTAACCC
CAACGTCAGCGAGCCGGTAAACCGTATCTTGAAGGGGATTGATAATATTATTCTGATCGATCCGCAAGACTACCTGCCAT
TTGTTTACCTAATGAATCATGCGTATCTGATCCTGACTGACTCAGGGGGTATTCAGGAAGAAGCGCCGTCATTGGGTAAA
CCTGTCTTGGTGATGCGTGACACCACCGAGCGCCCGGAAGCCGTAGATTCTGGCACTGTGCTGCTGGTGGGGACAAATAT
TAATAAAATTGTTGATGCAGTAACCCGCTTGCTGACTGATGAGACGGCTTATCATCAAATGACCCGGGCACACAATCCTT
ACGGTGACGGGTATGCCTGTCAACGCATCCTTAAAGCTTTAAAGAATCATCAGGTGACGCTATGA

Upstream 100 bases:

>100_bases
TTCATAGTCGTATGTCGCTCATATTGGTATGTCGCTCATCATGGTATGAACTCGTATCGAGTCACGCACTGAGCGACAAG
AAATCGTTAATGGACGCATT

Downstream 100 bases:

>100_bases
GTTTTGAAACTATTTCTGTTATCGGTCTTGGGTATATTGGTCTGCCGACCGCGGCGGCTTTTGCTTCGCGTAAAAAGAAA
GTGATTGGCGTTGACGTCAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRPTCRHCLRLTDLKRFTVKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMR
PGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLA
MYHFAPTENSRQNLLREWVPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGF
ERICSALAEIARKHPEVQVVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGK
PVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL

Sequences:

>Translated_394_residues
MRPTCRHCLRLTDLKRFTVKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMR
PGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLA
MYHFAPTENSRQNLLREWVPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGF
ERICSALAEIARKHPEVQVVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGK
PVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL
>Mature_394_residues
MRPTCRHCLRLTDLKRFTVKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMR
PGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLA
MYHFAPTENSRQNLLREWVPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGF
ERICSALAEIARKHPEVQVVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGK
PVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=78.4574468085106, Blast_Score=604, Evalue=1e-174,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 44577; Mature: 44577

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPTCRHCLRLTDLKRFTVKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREM
CCCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHH
LDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSA
HHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
SLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREWVP
HHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHCCHHEEEEEEEEECCCCCHHHHHHHHHCC
ENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGF
CCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCH
ERICSALAEIARKHPEVQVVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNH
HHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHCCHHHHHCC
AYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTD
EEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHC
ETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRPTCRHCLRLTDLKRFTVKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREM
CCCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHH
LDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSA
HHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
SLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREWVP
HHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHCCHHEEEEEEEEECCCCCHHHHHHHHHCC
ENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGF
CCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCH
ERICSALAEIARKHPEVQVVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNH
HHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHCCHHHHHCC
AYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTD
EEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHC
ETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]