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The map label for this gene is xanP [H]

Identifier: 22124027

GI number: 22124027

Start: 115622

End: 117058

Strand: Direct

Name: xanP [H]

Synonym: y0107

Alternate gene names: 22124027

Gene position: 115622-117058 (Clockwise)

Preceding gene: 22124025

Following gene: 22124028

Centisome position: 2.51

GC content: 50.59

Gene sequence:

>1437_bases
GTGAGCCGGATCATTAAAATGCCCCCTTTGCCGATCTGGAAATACCACGCCATGTCTACGCAATCTGCCGAACTTGATAC
TGCACCGCCATCACCGGCTCACCCCAGCGAATTGATCTACCACCTAGAAGACCGACCGCCACTCCCACAAACACTGTTTG
CCGCTTGCCAGCATCTCTTGGCGATGTTTGTTGCGGTAATCACCCCCGGTTTATTGATTTGTCAGGCTTTGGGGTTACCC
GCAGAAGATACTCAACGCATTATTAGTATGTCGTTATTTGCTTCGGGCCTAGCGTCTTTACTGCAGATTAAAACTTGGGG
CCCCGTGGGTTCAGGCCTGTTATCCATTCAAGGCACCAGTTTTAACTTTGTTTCTCCGTTGATTATGGGGGGGCTGGCGC
TAAAAAACGGTGGGGCAGATATCCCAACGATGATGGCGGCGCTGTTCGGTACGTTAATGGTTGCGTCCTGCACCGAGATC
TTACTCTCACATGTGCTGCATCTGGCACGCCGTATTATCACCCCGCTGGTATCCGGTATTGTGGTGATGATTATCGGCCT
GTCATTGATTCAAGTTGGGCTGACATCTATTGGTGGTGGTTATGGTGCGATGAGCGATAACACCTTTGGTGCACCGAAAA
ACTTATTATTAGCCGGTGCCGTATTGGGGGTGATCATTCTGCTTAACCGCCAGCGTAACCCGTATTTACGTGTTGCCTCT
TTGGTGATCGCTATGGCCGTGGGTTATCTGCTCGCCTGGGCATTGGGGATGTTGCCTGAGAGCCGCCCAGTTGTAGATAC
CGCGCTGATTACTATTCCAACGCCGTTGTACTATGGGCTGTCCTTCGACTGGAACTTACTGATTCCTCTGATGCTGATCT
TTATGGTGACCTCACTGGAAACCATAGGCGATATTACCGCAACATCTGATGTATCAGAGCAACCGGTTCGCGGCCCGTTA
TATATGAAACGCCTAAAAGGCGGTGTACTGGCCAATGGTTTGAACTCGATGCTGTCCGCTATATTCAATACCTTCCCCAA
CTCCTGCTTCGGTCAGAATAATGGCGTGATCCAATTGACTGGCGTTGCCAGCCGTTATGTCGGTTTTGTTGTGGCAATAA
TGCTCATCATTTTGGGCCTGTTCCCTGCTGTCGCTGGGTTTGTGCAGCATATTCCTGAGCCGGTACTGGGTGGAGCAACT
CTCGTGATGTTCGGGACTATCGCAGCGTCTGGTGTGCGTATTGTGTCACGCGAGACCCTGAATCGCCGGGCGATTATGAT
AATGGCCTTATCATTAGCGGTTGGTATGGGTGTCGCACAGCAGCCATTGATTTTGCAATTTGCGCCTGACTGGATCAAAA
CGCTGTTCTCTTCTGGGATTGCCGCTGGCGGTATTACTGCCATCGTACTTAACTTACTCTTCCCACAAGAAAAATAG

Upstream 100 bases:

>100_bases
TAGAAAAAAAAATGGTGAAGAATACAAGTTTAGTTATAAAAAATGTGAGTTAGCAAAAAAATAGAAATAATATAAAAACC
CAGCGCAAACGATTGCTTTT

Downstream 100 bases:

>100_bases
TCTTTACACTAACACATCACTGAAATGGTCGGTCATTAATGATGCCGGCCATTTTTTTTATGGTCCGATAGCTGATTATC
TATTGAGCTAATGGAAAAAT

Product: transport protein, symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSRIIKMPPLPIWKYHAMSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLP
AEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEI
LLSHVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVAS
LVIAMAVGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPL
YMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGAT
LVMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Sequences:

>Translated_478_residues
MSRIIKMPPLPIWKYHAMSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLP
AEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEI
LLSHVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVAS
LVIAMAVGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPL
YMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGAT
LVMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
>Mature_477_residues
SRIIKMPPLPIWKYHAMSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLLAMFVAVITPGLLICQALGLPA
EDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEIL
LSHVLHLARRIITPLVSGIVVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVASL
VIAMAVGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLETIGDITATSDVSEQPVRGPLY
MKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATL
VMFGTIAASGVRIVSRETLNRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=511, Percent_Identity=22.3091976516634, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI40316845, Length=511, Percent_Identity=22.3091976516634, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790087, Length=462, Percent_Identity=83.982683982684, Blast_Score=762, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=440, Percent_Identity=46.5909090909091, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=30.8695652173913, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788843, Length=399, Percent_Identity=27.0676691729323, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081818, Length=452, Percent_Identity=25.6637168141593, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=452, Percent_Identity=24.1150442477876, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=269, Percent_Identity=26.7657992565056, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 50705; Mature: 50574

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIIKMPPLPIWKYHAMSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLL
CCCCCCCCCCCCEEHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHH
AMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTS
HHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
FNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLVSGI
CHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVIAMAVGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHH
TIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLT
HHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
GVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHH
NRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
HHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRIIKMPPLPIWKYHAMSTQSAELDTAPPSPAHPSELIYHLEDRPPLPQTLFAACQHLL
CCCCCCCCCCCEEHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHH
AMFVAVITPGLLICQALGLPAEDTQRIISMSLFASGLASLLQIKTWGPVGSGLLSIQGTS
HHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
FNFVSPLIMGGLALKNGGADIPTMMAALFGTLMVASCTEILLSHVLHLARRIITPLVSGI
CHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVMIIGLSLIQVGLTSIGGGYGAMSDNTFGAPKNLLLAGAVLGVIILLNRQRNPYLRVAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVIAMAVGYLLAWALGMLPESRPVVDTALITIPTPLYYGLSFDWNLLIPLMLIFMVTSLE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCHHCCCCCCHHHHHHHHHHHHHHHHH
TIGDITATSDVSEQPVRGPLYMKRLKGGVLANGLNSMLSAIFNTFPNSCFGQNNGVIQLT
HHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
GVASRYVGFVVAIMLIILGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRETL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCHHHHHHHHH
NRRAIMIMALSLAVGMGVAQQPLILQFAPDWIKTLFSSGIAAGGITAIVLNLLFPQEK
HHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]