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The map label for this gene is cpxR [H]

Identifier: 22123988

GI number: 22123988

Start: 77048

End: 77770

Strand: Direct

Name: cpxR [H]

Synonym: y0067

Alternate gene names: 22123988

Gene position: 77048-77770 (Clockwise)

Preceding gene: 22123986

Following gene: 22123989

Centisome position: 1.67

GC content: 49.79

Gene sequence:

>723_bases
TTGCGTCAGAGAGGAGAAATAACCATGCATAAAATCCTATTAGTTGATGATGACCGTGAACTGACGTCGCTGTTGAAAGA
ATTGTTGGAAATGGAGGGTTTCAATGTTGTGGTCGCCTATGATGGCGAACAAGCGTTAAGCCAGCTAGATAGCTCTATCG
ACTTGTTATTGCTTGATATTATGATGCCGCGTAAAAACGGTATCGAAACCTTGAAAGAATTACGCCAACACCATCAGACC
CCGGTGATTATGCTGACTGCCCGTGGTAGTGAGTTGGATCGGGTGCTTGGCCTGGAATTAGGGGCCGATGATTATCTGGC
AAAACCGTTTAATGATCGCGAGCTGGTTGCTCGTATCCGCGCGATTTTACGCCGCTCCAATTGGAGTGAACAGCAACAAA
ATGCCGAGCAAGGCGCGCCTACACTGGAAGTTGATTGCCTGCAATTGAATCCGGGTCGTCAGGAAGCCAGTTTTGAAGGC
CAACCACTGGAATTAACCGGCACTGAGTTCACCCTGCTCTATCTGCTGGCTCAGCACCTTGGCCAAGTGGTGTCGCGGGA
GCATCTTAGCCAAGAGGTTCTGGGGAAACGATTGACCCCCTTTGACCGCGCGATTGATATGCACATCTCGAACTTACGCC
GTAAGTTACCAGACCGCAAAGACGGGCTACCGTGGTTTAAAACGTTGCGTGGCCGCGGCTACTTGATGGTATCAGAAACA
TGA

Upstream 100 bases:

>100_bases
TATCGGCCTGCCTGCAAACAAGCGTCAGTGGATGTAAAACTGGGGTCAGGGCATGTAAAGCTGAGTAAAGTCATGGAATA
CCGGCAGTTGATAACGTATT

Downstream 100 bases:

>100_bases
TAAACAGTTTAACGACGCGAATTTTTGCTATTTTCTGGTTTACTTTAGCGTTAGTGCTCATGCTAGTGCTGATGGTGCCA
AAGCTTGATTCGCGTCAACT

Product: DNA-binding transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MRQRGEITMHKILLVDDDRELTSLLKELLEMEGFNVVVAYDGEQALSQLDSSIDLLLLDIMMPRKNGIETLKELRQHHQT
PVIMLTARGSELDRVLGLELGADDYLAKPFNDRELVARIRAILRRSNWSEQQQNAEQGAPTLEVDCLQLNPGRQEASFEG
QPLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGLPWFKTLRGRGYLMVSET

Sequences:

>Translated_240_residues
MRQRGEITMHKILLVDDDRELTSLLKELLEMEGFNVVVAYDGEQALSQLDSSIDLLLLDIMMPRKNGIETLKELRQHHQT
PVIMLTARGSELDRVLGLELGADDYLAKPFNDRELVARIRAILRRSNWSEQQQNAEQGAPTLEVDCLQLNPGRQEASFEG
QPLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGLPWFKTLRGRGYLMVSET
>Mature_240_residues
MRQRGEITMHKILLVDDDRELTSLLKELLEMEGFNVVVAYDGEQALSQLDSSIDLLLLDIMMPRKNGIETLKELRQHHQT
PVIMLTARGSELDRVLGLELGADDYLAKPFNDRELVARIRAILRRSNWSEQQQNAEQGAPTLEVDCLQLNPGRQEASFEG
QPLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGLPWFKTLRGRGYLMVSET

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=89.6551724137931, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1789809, Length=237, Percent_Identity=40.084388185654, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=40.6113537117904, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=37.7777777777778, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=37.3333333333333, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=34.1991341991342, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=36.480686695279, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=38.3620689655172, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=35.9649122807018, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787229, Length=239, Percent_Identity=31.7991631799163, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.4978165938865, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=32.9059829059829, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=29.3859649122807, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=39.0909090909091, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790299, Length=139, Percent_Identity=38.8489208633094, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=38.9830508474576, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=38.3928571428571, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=144, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27468; Mature: 27468

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQRGEITMHKILLVDDDRELTSLLKELLEMEGFNVVVAYDGEQALSQLDSSIDLLLLDI
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCHHHHHHHHH
MMPRKNGIETLKELRQHHQTPVIMLTARGSELDRVLGLELGADDYLAKPFNDRELVARIR
HCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCHHCCCCCCHHHHHHHH
AILRRSNWSEQQQNAEQGAPTLEVDCLQLNPGRQEASFEGQPLELTGTEFTLLYLLAQHL
HHHHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHH
GQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGLPWFKTLRGRGYLMVSET
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEECC
>Mature Secondary Structure
MRQRGEITMHKILLVDDDRELTSLLKELLEMEGFNVVVAYDGEQALSQLDSSIDLLLLDI
CCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCHHHHHHHHH
MMPRKNGIETLKELRQHHQTPVIMLTARGSELDRVLGLELGADDYLAKPFNDRELVARIR
HCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCHHCCCCCCHHHHHHHH
AILRRSNWSEQQQNAEQGAPTLEVDCLQLNPGRQEASFEGQPLELTGTEFTLLYLLAQHL
HHHHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHH
GQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGLPWFKTLRGRGYLMVSET
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]