BacMap

Definition	Streptococcus pneumoniae ATCC 700669, complete genome.
Accession	NC_011900
Length	2,221,315

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The map label for this gene is yvgN [H]

Identifier: 221232202

GI number: 221232202

Start: 1400199

End: 1401041

Strand: Reverse

Name: yvgN [H]

Synonym: SPN23F_14420

Alternate gene names: 221232202

Gene position: 1401041-1400199 (Counterclockwise)

Preceding gene: 221232203

Following gene: 221232201

Centisome position: 63.07

GC content: 42.23

Gene sequence:

>843_bases
ATGAATACCTATCAATTAAATAATGGAGTAAAAATTCCAGTATTGGGATTTGGAACTTTTAAGGCTAAGGATGGAGAAGA
AGCCTATCGTGCAGTGTTAGAAGCCTTGAAGGCTGGTTATCGTCATATTGATACGGCAGCGATTTATCAGAATGAAGAAA
GTGTTGGCCAAGCAATCAAAGATAGCGGAGTTCCACGAGAGGATTTGTTCGTAACTACCAAGCTTTGGAATAGTCAGCAA
ACCTATGAGCAAGCTCGTCAGGCTTTTGCAGAGTCTTTAGAGAAGCTGGGTTTGGATTATTTGGATTTGTATTTGATTCA
TTGGCCGAACCCAAAACCGCTTAGAGAAAATGACCAATGGAAAATCCGAAATGCGGAAGTTTGGAGAGCGATGGAAGACC
TCTATCAAGAAGGGAAAATCCGTGCTATCGGTGTTAGCAATTTTCTTCCCCATCATTTGGATGCCTTGCTTGCAACTGCA
ACTATCGTTCCTGCGGTCAATCAGGTTCGCTTGGCACCAGGTGTGTATCAAGAGGAAGTCGTAGCTTACTGTAGAGAAAA
AGGAATTTTATTGGAAGCTTGGGGACCTTTTGGTCAGGGAGAACTATTTGATAGTAAGGAAGTCCAAGAAATCGCAGCAA
ATCATGGAAAGTCTGTTGCTCAGATAGCCTTGGCCTGGAGCTTGGCAGAAGGATTTTTACCACTTCCGAAATCTGTTACA
GCATCTCGTATTCAGGCTAATCTTGATTGCTTTGGAATTGAATTGAGCCATGAGGAACATGAAACCTTAAAAACGATAGC
TGTTCATTCTGGTGCTCCACGAGCTGATGATATGGATTTTTAG

Upstream 100 bases:

>100_bases
GGTCTGTCAGATATGTGATAGACTTATTTTTTACAGAAGATAGTACTACTTAAAAAATGTTTTATGCTATAAATGATAAA
TAAAAGAGAAGGAGAAGCAT

Downstream 100 bases:

>100_bases
AAAATCATAAAAAGAATTGTACATTATTCTAATTTTTGATATAATAGTCAGCAGGAAAGAAAGTCTTATGGCGTTCTTCA
AGCGAGCTTGGGACAGTGGG

Product: aldo/keto reductase family protein

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNTYQLNNGVKIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREDLFVTTKLWNSQQ
TYEQARQAFAESLEKLGLDYLDLYLIHWPNPKPLRENDQWKIRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLATA
TIVPAVNQVRLAPGVYQEEVVAYCREKGILLEAWGPFGQGELFDSKEVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT
ASRIQANLDCFGIELSHEEHETLKTIAVHSGAPRADDMDF

Sequences:

>Translated_280_residues
MNTYQLNNGVKIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREDLFVTTKLWNSQQ
TYEQARQAFAESLEKLGLDYLDLYLIHWPNPKPLRENDQWKIRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLATA
TIVPAVNQVRLAPGVYQEEVVAYCREKGILLEAWGPFGQGELFDSKEVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT
ASRIQANLDCFGIELSHEEHETLKTIAVHSGAPRADDMDF
>Mature_280_residues
MNTYQLNNGVKIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREDLFVTTKLWNSQQ
TYEQARQAFAESLEKLGLDYLDLYLIHWPNPKPLRENDQWKIRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLATA
TIVPAVNQVRLAPGVYQEEVVAYCREKGILLEAWGPFGQGELFDSKEVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT
ASRIQANLDCFGIELSHEEHETLKTIAVHSGAPRADDMDF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=37.7622377622378, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=37.7622377622378, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=37.9310344827586, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4502049, Length=284, Percent_Identity=38.3802816901408, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI93277124, Length=294, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI291291012, Length=259, Percent_Identity=36.2934362934363, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI310109920, Length=307, Percent_Identity=34.5276872964169, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI45446745, Length=307, Percent_Identity=34.5276872964169, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4503285, Length=307, Percent_Identity=34.5276872964169, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI5453543, Length=307, Percent_Identity=34.2019543973941, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI310109922, Length=297, Percent_Identity=33.6700336700337, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI24497585, Length=288, Percent_Identity=34.0277777777778, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI24497583, Length=288, Percent_Identity=34.375, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI5174695, Length=291, Percent_Identity=31.6151202749141, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=32.2344322344322, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI300116271, Length=286, Percent_Identity=28.6713286713287, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI310109926, Length=111, Percent_Identity=48.6486486486487, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI207028673, Length=111, Percent_Identity=48.6486486486487, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI87082198, Length=257, Percent_Identity=42.8015564202335, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1786400, Length=256, Percent_Identity=36.71875, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1788081, Length=279, Percent_Identity=29.7491039426523, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788070, Length=296, Percent_Identity=26.0135135135135, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994888, Length=270, Percent_Identity=28.1481481481481, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787674, Length=294, Percent_Identity=24.1496598639456, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081735, Length=308, Percent_Identity=25.6493506493506, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538386, Length=284, Percent_Identity=38.3802816901408, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71998625, Length=270, Percent_Identity=38.8888888888889, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17564128, Length=295, Percent_Identity=36.271186440678, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=35.3535353535354, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17537077, Length=291, Percent_Identity=37.8006872852234, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17537075, Length=291, Percent_Identity=37.1134020618557, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=35.9259259259259, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17552492, Length=266, Percent_Identity=33.4586466165414, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562292, Length=282, Percent_Identity=29.0780141843972, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17550248, Length=280, Percent_Identity=33.2142857142857, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17566692, Length=281, Percent_Identity=30.9608540925267, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17561300, Length=258, Percent_Identity=31.3953488372093, Blast_Score=133, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320576, Length=300, Percent_Identity=42.3333333333333, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=41.4383561643836, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322556, Length=269, Percent_Identity=38.6617100371747, Blast_Score=188, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319625, Length=275, Percent_Identity=34.9090909090909, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321896, Length=283, Percent_Identity=33.5689045936396, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320079, Length=286, Percent_Identity=31.1188811188811, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24663317, Length=293, Percent_Identity=38.9078498293515, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24657054, Length=292, Percent_Identity=38.3561643835616, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24644950, Length=293, Percent_Identity=37.542662116041, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI221378297, Length=313, Percent_Identity=35.7827476038339, Blast_Score=180, Evalue=7e-46,
Organism=Drosophila melanogaster, GI21356425, Length=283, Percent_Identity=35.3356890459364, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129731, Length=273, Percent_Identity=36.6300366300366, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45553081, Length=286, Percent_Identity=34.2657342657343, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24662789, Length=271, Percent_Identity=32.8413284132841, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24662781, Length=276, Percent_Identity=35.8695652173913, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=36.6300366300366, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281366140, Length=249, Percent_Identity=32.5301204819277, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646155, Length=276, Percent_Identity=27.1739130434783, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31308; Mature: 31308

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYQLNNGVKIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIK
CCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHH
DSGVPREDLFVTTKLWNSQQTYEQARQAFAESLEKLGLDYLDLYLIHWPNPKPLRENDQW
HCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCE
KIRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLATATIVPAVNQVRLAPGVYQEEV
EECHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
VAYCREKGILLEAWGPFGQGELFDSKEVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT
HHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHH
ASRIQANLDCFGIELSHEEHETLKTIAVHSGAPRADDMDF
HHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNTYQLNNGVKIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIK
CCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHH
DSGVPREDLFVTTKLWNSQQTYEQARQAFAESLEKLGLDYLDLYLIHWPNPKPLRENDQW
HCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCE
KIRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLATATIVPAVNQVRLAPGVYQEEV
EECHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
VAYCREKGILLEAWGPFGQGELFDSKEVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT
HHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHH
ASRIQANLDCFGIELSHEEHETLKTIAVHSGAPRADDMDF
HHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]