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The map label for this gene is guaA [H]

Identifier: 221232174

GI number: 221232174

Start: 1374113

End: 1375675

Strand: Reverse

Name: guaA [H]

Synonym: SPN23F_14100

Alternate gene names: 221232174

Gene position: 1375675-1374113 (Counterclockwise)

Preceding gene: 221232176

Following gene: 221232173

Centisome position: 61.93

GC content: 42.1

Gene sequence:

>1563_bases
ATGAGCAACATTTCAACTGATTTGCAAGATGTAGAAAAAATCATCGTATTGGACTATGGTAGCCAGTACAACCAGCTGAT
TTCACGCCGTATCCGTGAGATTGGTGTTTTTTCAGAACTAAAAAGCCATAAAATTTCAGCTGCTGAAGTTCGTGAAGTCA
ATCCTGTAGGAATTATTCTATCAGGTGGTCCAAATTCTGTATATGAAGATGGTTCATTTGATATTGACCCAGAAATCTTC
GAACTCGGAATTCCAATTTTGGGAATCTGTTATGGTATGCAGTTATTGACCCATAAACTTGGAGGAAAAGTTGTTCCTGC
AGGTGATGCTGGAAATCGTGAATACGGTCAATCAACCCTAACTCACACACCATCAGCGCTTTTTGAATCAACACCTGATG
AACAGACTGTTTTGATGAGCCATGGTGATGCGGTTACTGAGATTCCTGCTGACTTTGTTCGTACAGGTACATCAGCTGAC
TGCCTATACGCAGCCATCGAAAACCCAGATAAACACATTTACGGTATCCAATTCCACCCAGAAGTTCGTCATTCTGTATA
CGGAAATGATATCCTTCGTAACTTTGCCCTTAACATTTGTAAGGCTAAAGGTGACTGGTCAATGGATAATTTCATTGACA
TGCAGATCAAAAAAATTCGTGAAACCGTCGGTGATAAACGTGTCCTTCTTGGTCTATCAGGTGGTGTTGACTCATCTGTC
GTTGGGGTTCTTCTCCAAAAAGCGATTGGCGATCAATTGATCTGTATCTTCGTAGACCACGGTCTTCTTCGTAAAGGCGA
AGCTGATCAAGTTATGGACATGCTCGGTGGTAAGTTTGGTTTGAATATCGTCAAAGCAGACGCTGCTAAACGTTTCCTTG
ACAAACTTGCTGGCGTTTCTGATCCTGAACAAAAACGTAAAATCATCGGTAACGAGTTTGTCTATGTATTCGATGACGAA
GCAAGCAAGCTCAAAGATGTGAAATTCCTTGCTCAAGGTACTTTATATACAGATGTTATCGAGTCTGGTACGGATACAGC
TCAAACTATCAAGTCACACCACAACGTAGGTGGTCTTCCAGAAGATATGCAGTTTGAATTGATTGAACCACTCAATACTC
TTTACAAGGATGAAGTTCGTGCTCTTGGTACAGAGCTTGGTATGCCAGACCATATCGTATGGCGCCAACCATTCCCAGGA
CCAGGACTTGCTATCCGTGTCATGGGTGAAATCACTGAAGAGAAACTTGAAACCGTTCGTGAATCAGACGCTATTCTTCG
TGAAGAAATCGCTAAAGCTGGACTTGACCGCGATATTTGGCAATACTTCACTGTTAACACAGGCGTTCGTTCAGTCGGTG
TTATGGGTGACGGTCGTACGTATGACTACACGATTGCAATCCGTGCTATCACTTCTATCGATGGTATGACTGCTGATTTT
GCCAAAATTCCATGGGAAGTACTTCAAAAAATCTCAGTACGTATCGTAAATGAAGTGGATCATGTTAACCGTATCGTCTA
CGATATTACAAGTAAACCACCTGCAACAGTTGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
TAAACTAGAAAAAGTCAAACTTCGCCTTGTTTAGTTGGTAATTCGCCCTTATTTGTGATAGAATATTGAGAAAAGATATT
TCTTTTGAGAAAGGAAAAAG

Downstream 100 bases:

>100_bases
TCGCAAAAAAATTAAAAGCTTTGTAAAATCAACGGTTACAGAGGATTAAAAACTGTAACTGGGATTAAAACGGGAACATT
TACTAAAAAGAATAAATTGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIF
ELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
CLYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSV
VGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDE
ASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPG
PGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
AKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

Sequences:

>Translated_520_residues
MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIF
ELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
CLYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSV
VGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDE
ASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPG
PGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
AKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
>Mature_519_residues
SNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFE
LGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADC
LYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSVV
GVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEA
SKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGP
GLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFA
KIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=568, Percent_Identity=34.330985915493, Blast_Score=284, Evalue=2e-76,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=51.8234165067178, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=28.494623655914, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=35.6140350877193, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=35.6140350877193, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=35.6140350877193, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=51.8304431599229, Blast_Score=504, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322638, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=36.4963503649635, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57489; Mature: 57358

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIIL
CCCCCHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEE
SGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTL
ECCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCHH
THTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADCLYAAIENPDKHIYGIQFHP
HCCCHHHHCCCCCCCEEEEECCCHHHHCCHHHHHCCCCCCEEEEEECCCCCEEEEEEECC
EVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVS
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCC
DPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLP
CHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCC
EDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGPGLAIRVMGEITEEKLETVR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHH
ESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
HHHHHHHHHHHHCCCCHHHHHHHEECCCCCEEEEECCCCEEEEEEEEEEEHHCCCCCCHH
AKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
HHCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
SNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIIL
CCCCHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEE
SGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTL
ECCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCHH
THTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADCLYAAIENPDKHIYGIQFHP
HCCCHHHHCCCCCCCEEEEECCCHHHHCCHHHHHCCCCCCEEEEEECCCCCEEEEEEECC
EVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVS
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCC
DPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLP
CHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCC
EDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGPGLAIRVMGEITEEKLETVR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHH
ESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
HHHHHHHHHHHHCCCCHHHHHHHEECCCCCEEEEECCCCEEEEEEEEEEEHHCCCCCCHH
AKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
HHCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA