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The map label for this gene is ntpA [H]

Identifier: 221231992

GI number: 221231992

Start: 1176191

End: 1177966

Strand: Reverse

Name: ntpA [H]

Synonym: SPN23F_12090

Alternate gene names: 221231992

Gene position: 1177966-1176191 (Counterclockwise)

Preceding gene: 221231993

Following gene: 221231991

Centisome position: 53.03

GC content: 39.64

Gene sequence:

>1776_bases
TTGACTCAAGGGAAGATTATAAAAGTATCGGGACCTCTAGTTATTGCATCAGGTATGCAGGAGGCTAATATTCAAGATAT
TTGCCGTGTAGGTAAGCTAGGGTTAATCGGTGAAATTATTGAAATGAGAAGAGATCAGGCATCTATCCAAGTCTATGAAG
AAACATCTGGTCTTGGTCCGGGAGAACCTGTTGTTACAACTGGAGAACCTCTCTCGGTTGAATTAGGGCCAGGATTGATT
TCTCAAATGTTTGATGGCATACAACGCCCATTAGATCGATTTAAATTGGCTACTCATAATGATTTTCTAGTTCGTGGGGT
AGAAGTTCCAAGTTTGGATAGAGATATTAAGTGGCATTTTGATTCCACTATAGCAATTGGTCAAAAAGTGAGTACGGGTG
ATATTCTTGGAACTGTCAAGGAAACCGAGGTAGTTAATCATAAAATTATGGTTCCTTATGGAGTATCTGGAGAAGTCGTT
TCTATTGCATCTGGCGATTTTACAATTGATGAAGTTGTATATGAAATAAAAAAATTGGACGGTAGTTTCTATAAAGGAAC
GCTTATGCAAAAATGGCCTGTCCGCAAGGCGCGTCCTGTTTCTAAACGTTTAATTCCAGAAGAACCATTAATCACAGGTC
AACGAGTTATTGATGCATTCTTTCCAGTAACCAAAGGGGGAGCTGCAGCAGTTCCTGGACCGTTTGGAGCAGGAAAGACA
GTTGTACAACACCAAGTAGCTAAATTTGCCAATGTTGATATTGTTATTTATGTCGGTTGTGGAGAACGTGGAAATGAAAT
GACGGATGTACTGAATGAGTTTCCTGAGTTGATTGACCCTAATACCGGACAATCAATTATGCAACGGACAGTTCTGATTG
CTAATACTTCAAATATGCCTGTTGCTGCTCGTGAGGCTTCAATTTATACAGGAATTACCATGGCTGAGTATTTTCGTGAT
ATGGGCTACTCTGTCGCCATTATGGCTGATTCAACTTCACGTTGGGCAGAAGCGCTACGTGAAATGTCAGGACGTCTAGA
AGAAATGCCTGGTGATGAGGGTTATCCTGCTTATCTGGGAAGTCGTATCGCTGAATATTATGAAAGAGCAGGACGTTCTC
AGGTTCTAGGGCTTCCAGAACGTGAAGGAACGATTACTGCTATTGGAGCTGTATCGCCACCTGGTGGAGATATTTCAGAA
CCAGTTACTCAAAACACTTTACGGATTGTGAAAGTTTTTTGGGGGCTTGATGCTCCGTTGGCACAGCGACGTCATTTTCC
TGCAATTAACTGGCTTACATCTTATTCACTATATAAAGACAGTGTGGGCACTTATATAGATGGTAAAGAGAAGACAGATT
GGAATAGTAAAATAACTCGTGCGATGAACTACTTACAACGGGAATCTAGTTTAGAGGAAATTGTTCGTCTTGTTGGAATT
GATTCTCTGTCTGATAATGAACGACTAACGATGGAAATTGCTAAACAAATTCGAGAAGATTATTTGCAACAGAACGCTTT
TGATTCGGTAGATACATTCACTTCGTTTGCAAAACAAGAAGCAATGCTAAGTAATATTCTCACTTTTGCTGATCAGGCAA
ATCATGCTTTAGAGTTGGGTTCTTACTTTACAGAGATTATGGAAGGTACCGTGGCAGTTCGAGACCGTATGGCGAGAAGT
AAATATGTTTCAGAAGATAGATTAGATGAAATCAAAATTATATCAAATGAGATTACACATCAAATTCATTTGATATTAGA
AACAGGAGGTCTATAA

Upstream 100 bases:

>100_bases
ATAATGTAGAGAAAGCAGTAGGACACAATATTTTATAATAATGTACAAAATTGTCTGTAATATTATTCTATAATTTTTGG
ACTTAGTAAGGAGAATAACT

Downstream 100 bases:

>100_bases
ATGAGTGTTATAAAAGAATACAGAACTGCTAGTGAAGTTGTTGGGCCTCTTATGATTGTTGAACAAGTAAATAATGTGTC
TTACAATGAGTTAGTTGAAA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLI
SQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHFDSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVV
SIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDAFFPVTKGGAAAVPGPFGAGKT
VVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQVLGLPEREGTITAIGAVSPPGGDISE
PVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDGKEKTDWNSKITRAMNYLQRESSLEEIVRLVGI
DSLSDNERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIMEGTVAVRDRMARS
KYVSEDRLDEIKIISNEITHQIHLILETGGL

Sequences:

>Translated_591_residues
MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLI
SQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHFDSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVV
SIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDAFFPVTKGGAAAVPGPFGAGKT
VVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQVLGLPEREGTITAIGAVSPPGGDISE
PVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDGKEKTDWNSKITRAMNYLQRESSLEEIVRLVGI
DSLSDNERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIMEGTVAVRDRMARS
KYVSEDRLDEIKIISNEITHQIHLILETGGL
>Mature_590_residues
TQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLIS
QMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHFDSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVVS
IASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDAFFPVTKGGAAAVPGPFGAGKTV
VQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRDM
GYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQVLGLPEREGTITAIGAVSPPGGDISEP
VTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDGKEKTDWNSKITRAMNYLQRESSLEEIVRLVGID
SLSDNERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIMEGTVAVRDRMARSK
YVSEDRLDEIKIISNEITHQIHLILETGGL

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=542, Percent_Identity=54.6125461254613, Blast_Score=601, Evalue=1e-172,
Organism=Homo sapiens, GI32189394, Length=366, Percent_Identity=28.9617486338798, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI19913428, Length=335, Percent_Identity=25.6716417910448, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19913426, Length=335, Percent_Identity=25.3731343283582, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI50345984, Length=313, Percent_Identity=26.1980830670927, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4757810, Length=313, Percent_Identity=26.1980830670927, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790170, Length=328, Percent_Identity=28.6585365853659, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788251, Length=323, Percent_Identity=26.0061919504644, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1790172, Length=244, Percent_Identity=27.0491803278689, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17565854, Length=542, Percent_Identity=52.3985239852399, Blast_Score=582, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI25144756, Length=317, Percent_Identity=29.9684542586751, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=462, Percent_Identity=24.8917748917749, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17570191, Length=475, Percent_Identity=24.6315789473684, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988080, Length=298, Percent_Identity=27.5167785234899, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71988063, Length=298, Percent_Identity=27.5167785234899, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71988074, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320016, Length=332, Percent_Identity=47.289156626506, Blast_Score=319, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6322581, Length=312, Percent_Identity=30.4487179487179, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319603, Length=338, Percent_Identity=25.1479289940828, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319370, Length=248, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583988, Length=540, Percent_Identity=54.0740740740741, Blast_Score=600, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24583986, Length=540, Percent_Identity=54.0740740740741, Blast_Score=600, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24583984, Length=540, Percent_Identity=54.0740740740741, Blast_Score=600, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24583992, Length=539, Percent_Identity=52.3191094619666, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI20129479, Length=537, Percent_Identity=51.9553072625698, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24638766, Length=370, Percent_Identity=28.9189189189189, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28574560, Length=317, Percent_Identity=32.1766561514196, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI281361666, Length=336, Percent_Identity=25.5952380952381, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646341, Length=336, Percent_Identity=25.5952380952381, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136796, Length=336, Percent_Identity=25.5952380952381, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24658560, Length=299, Percent_Identity=27.4247491638796, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 65280; Mature: 65149

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGP
CCCCCEEEECCCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCC
GEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHF
CCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCEEEEC
DSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVVSIASGDFTIDEVVYEIKKLD
CCEEEECCCCCCCHHHCCHHHHHHHCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHC
GSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDAFFPVTKGGAAAVPGPFGAGKT
CCHHCCCCHHCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
VVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMP
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITMAEYFRDMGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLG
EEECCCHHHHCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRIAEYYERAGRSQVLGLPEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPL
HHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
AQRRHFPAINWLTSYSLYKDSVGTYIDGKEKTDWNSKITRAMNYLQRESSLEEIVRLVGI
HHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSLSDNERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
SYFTEIMEGTVAVRDRMARSKYVSEDRLDEIKIISNEITHQIHLILETGGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEEEEECCCC
>Mature Secondary Structure 
TQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGP
CCCCEEEECCCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCC
GEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHF
CCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCCCCEEEEC
DSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVVSIASGDFTIDEVVYEIKKLD
CCEEEECCCCCCCHHHCCHHHHHHHCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHC
GSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDAFFPVTKGGAAAVPGPFGAGKT
CCHHCCCCHHCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
VVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMP
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITMAEYFRDMGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLG
EEECCCHHHHCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRIAEYYERAGRSQVLGLPEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPL
HHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
AQRRHFPAINWLTSYSLYKDSVGTYIDGKEKTDWNSKITRAMNYLQRESSLEEIVRLVGI
HHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSLSDNERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
SYFTEIMEGTVAVRDRMARSKYVSEDRLDEIKIISNEITHQIHLILETGGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11442348 [H]