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The map label for this gene is guaC [H]

Identifier: 221231943

GI number: 221231943

Start: 1120504

End: 1121490

Strand: Reverse

Name: guaC [H]

Synonym: SPN23F_11440

Alternate gene names: 221231943

Gene position: 1121490-1120504 (Counterclockwise)

Preceding gene: 221231944

Following gene: 221231942

Centisome position: 50.49

GC content: 42.25

Gene sequence:

>987_bases
ATGTTAAATGAATTTCCAATTTTTGATTACGAAGATATTCAATTGATTCCAAATAAATGTGTCATTAAAAGCCGTGCAGA
AGCGGATACAAGTGTCACTTTAGGAAATCACACCTTTAAACTACCTGTTGTGCCAGCGAATATGCAGACGATTTTGGATG
AAAATGTAGCAGAGCAACTGGCTAAAGGTGGTTACTTCTACATTATGCACCGTTTTGATGAGGCAGGACGCATTCCTTTT
ATTAAACGAATGCACAATCAAGGGCTCATTGCTTCCATATCTGTCGGTGTTAAGGACTATGAGTATGATTTCGTTAGACA
GCTCAAGACTGATGCTCCTGAGTATATCACTATTGATATTGCTCATGGTCATGCGGATAGCGTGATTTCTATGATTCAAC
ACATCAAGAAAGAATTGCCAGATACCTTTGTCATTGCTGGAAATGTGGGAACACCAGAAGCTGTGCGTGAATTGGAAAAT
GCTGGTGCAGATGCTACTAAGGTCGGAATCGGTCCTGGTAAGGTTTGTATCACCAAGGTTAAGACTGGTTTTGGTACAGG
TGGTTGGCAGTTGGCTGCTCTACGCTGGTGTGCCAAGGCTGCGCGTAAACCGATTATCGCTGATGGAGGAATTCGTACTC
ACGGTGATATTGCCAAGTCTATCCGCTTCGGTGCTAGCATGATCATGATTGGTTCCCTCTTTGCAGGACATATTGAAAGT
CCAGGGAAAACGATTGAAGTCGATGGTGAACAGTTCAAAGAATATTATGGTTCAGCCTCACAATATCAAAAAGGTGCTTA
CAAAAATGTGGAAGGCAAACGTATCTTGCTTCCTGCTAAAGGTCATCTGCAAGACACTTTAACTGAGATGGAACAAGACC
TTCAAAGTGCTATTTCTTATGCAGGTGGACGTCAGGTTGCTGACCTTAAACACGTTGATTATGTGATCGTGAAAAACTCC
ATCTGGAATGGGGATGCTTCCCACTAA

Upstream 100 bases:

>100_bases
AAAACTGTACTTTGGTTTATAATGAATTAAGGAAACGTCGGAAAAGGCGTAGTGATGCAAGAGCATAGGTAGGTCATTAC
AAAAGAAACGAGACATCGAT

Downstream 100 bases:

>100_bases
GACGGGGTCTTTGACCAAAAAACTTGTTATTAGAGCAAATTTCTGTTATAATAAAACAAGTTTCCACCCTTAGTGTAATG
GATATCACGTAAGATTCCGG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPF
IKRMHNQGLIASISVGVKDYEYDFVRQLKTDAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNS
IWNGDASH

Sequences:

>Translated_328_residues
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPF
IKRMHNQGLIASISVGVKDYEYDFVRQLKTDAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNS
IWNGDASH
>Mature_328_residues
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPF
IKRMHNQGLIASISVGVKDYEYDFVRQLKTDAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNS
IWNGDASH

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI50541952, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI50541948, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI50541956, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI156104880, Length=320, Percent_Identity=30.625, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI217035150, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI217035146, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI217035148, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI217035152, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI34328928, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI34328930, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI156616279, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI66933016, Length=238, Percent_Identity=33.1932773109244, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786293, Length=340, Percent_Identity=31.7647058823529, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1788855, Length=214, Percent_Identity=36.4485981308411, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560440, Length=324, Percent_Identity=34.2592592592593, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71994389, Length=169, Percent_Identity=37.2781065088757, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994385, Length=169, Percent_Identity=37.2781065088757, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323464, Length=175, Percent_Identity=33.7142857142857, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6322012, Length=256, Percent_Identity=28.515625, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323585, Length=182, Percent_Identity=32.4175824175824, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319352, Length=210, Percent_Identity=27.1428571428571, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641071, Length=192, Percent_Identity=33.8541666666667, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24641073, Length=192, Percent_Identity=33.8541666666667, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28571163, Length=192, Percent_Identity=33.8541666666667, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 35982; Mature: 35982

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQL
CCCCCCCCCCCCCEECCCHHEECCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHH
AKGGYFYIMHRFDEAGRIPFIKRMHNQGLIASISVGVKDYEYDFVRQLKTDAPEYITIDI
HCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEE
AHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKV
ECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
ECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISY
CCCEEEECHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
AGGRQVADLKHVDYVIVKNSIWNGDASH
CCCCEEEHHHHCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQL
CCCCCCCCCCCCCEECCCHHEECCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHH
AKGGYFYIMHRFDEAGRIPFIKRMHNQGLIASISVGVKDYEYDFVRQLKTDAPEYITIDI
HCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEE
AHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKV
ECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
ECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISY
CCCEEEECHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
AGGRQVADLKHVDYVIVKNSIWNGDASH
CCCCEEEHHHHCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA