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The map label for this gene is mutX [H]

Identifier: 221231880

GI number: 221231880

Start: 1049770

End: 1050234

Strand: Reverse

Name: mutX [H]

Synonym: SPN23F_10710

Alternate gene names: 221231880

Gene position: 1050234-1049770 (Counterclockwise)

Preceding gene: 221231881

Following gene: 221231879

Centisome position: 47.28

GC content: 44.52

Gene sequence:

>465_bases
ATGCCTCAGTTAGCGACGATTTGCTACATTGATAATGGGAAAGAACTGCTCATGCTCCATCGTAATAAGAAACCCAATGA
TGTCCATGAAGGGAAATGGATTGGTGTGGGTGGTAAGCTAGAGAGAGGAGAGACGCCCCAGGAATGCGCGACGCGTGAAA
TCCTTGAAGAAACAGGGCTCAAAGCCAAGCCAGTTCTAAAAGGTGTCATCACTTTTCCTGAATTTACACCAGATTTAGAC
TGGTACACCTATGTTTTTAAGGTGACGGAGTTTGAGGGCGACTTGATTGACTGCAATGAGGGGACGCTAGAATGGGTTCC
CTATGATGAGGTTTTGAGCAAGCCGACTTGGGAAGGTGACCACACCTTTGTTGAGTGGCTTTTAGAGGATAAACCCTTCT
TTTCAGCCAAGTTTGTTTATGATGGGGATAAATTGTTGGATACCCAAGTTGATTTCTATGAATAA

Upstream 100 bases:

>100_bases
TTATAGAGGATTTTGGGGTTCCAAGCCCTTTTCCAAGGCCAATGCATTCTTAAAAGAGACAGGACAAGAGCCAATCGATT
GGCTTAGATAAGGAGAAAAT

Downstream 100 bases:

>100_bases
AGGAGAAAGCAGATGCTACTAATCAAAAATGGTCGTGTAATGGATCCCAAGTCTGGTTTGGATCAAGTTTGTGATGTCTT
AGTTCAAGATGGGAAAATTA

Product: mutator MutX protein (7,8-dihydro-8-oxoguanine-triphosphatase)

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECATREILEETGLKAKPVLKGVITFPEFTPDLD
WYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE

Sequences:

>Translated_154_residues
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECATREILEETGLKAKPVLKGVITFPEFTPDLD
WYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
>Mature_153_residues
PQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECATREILEETGLKAKPVLKGVITFPEFTPDLDW
YTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 17842; Mature: 17711

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECATREILEETGL
CCCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
KAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGD
CCCCHHEEEEECCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEEECHHHHHCCCCCCCC
HTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
HHHEEEECCCCCCEEEEEEECCCEEECCCCCCCC
>Mature Secondary Structure 
PQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECATREILEETGL
CCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
KAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGD
CCCCHHEEEEECCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEEECHHHHHCCCCCCCC
HTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
HHHEEEECCCCCCEEEEEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]