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The map label for this gene is trx

Identifier: 221230938

GI number: 221230938

Start: 3258118

End: 3259494

Strand: Direct

Name: trx

Synonym: MLBr_02703

Alternate gene names: 221230938

Gene position: 3258118-3259494 (Clockwise)

Preceding gene: 221230937

Following gene: 221230939

Centisome position: 99.7

GC content: 56.5

Gene sequence:

>1377_bases
ATGAACACCACTCCTTCTGCGCATGAGACGATACACGAAGTGATCGTTATTGGCTCCGGTCCAGCAGGCTACACTGCTGC
CCTGTACGCCGCTCGTGCACAGCTAACACCGCTGGTATTTGAGGGTACCTCATTCGGCGGCGCGCTGATGACCACCACCG
AGGTGGAAAACTACCCAGGTTTTCGCAACGGCATAACCGGCCCGGAGTTGATGGACGATATGCGTGAACAGGCACTGCGA
TTCGGCGCGGAACTGCGGACCGAAGACGTCGAGTCGGTATCATTGCGTGGCCCGATCAAATCGGTCGTCACCGCTGAAGG
ACAGACTTATCAGGCCCGAGCCGTCATCCTCGCCATGGGTACCTCCGTGCGTTATCTACAGATCCCCGGCGAGCAAGAAT
TGCTAGGACGTGGCGTGAGTGCATGCGCGACCTGCGACGGGTCCTTTTTCCGCGGCCAAGACATTGCCGTCATTGGCGGT
GGAGACTCAGCGATGGAGGAAGCCCTCTTTTTGACCCGGTTCGCCCGCAGCGTCACGCTCGTGCACCGCCGCGACGAATT
CCGAGCTTCTAAGATCATGCTCGGTCGCGCCCGTAACAATGACAAGATCAAATTCATCACCAACCACACCGTGGTCGCGG
TGAACGGGTATACAACAGTGACCGGATTGCGGTTGCGTAACACCACAACGGGAGAGGAAACCACGCTAGTAGTGACCGGG
GTTTTTGTTGCAATTGGCCATGAACCACGTTCCAGCCTGGTGAGCGATGTCGTCGACATAGACCCGGATGGCTACGTCCT
GGTGAAAGGACGTACGACGAGTACATCGATGGACGGCGTTTTTGCGGCCGGCGACCTGGTAGATCGCACCTACCGGCAGG
CGATCACTGCCGCAGGTAGTGGCTGTGCCGCCGCCATCGACGCCGAACGTTGGTTGGCGGAGCATGCCGGGTCAAAAGCT
AACGAAACAACAGAGGAAACTGGAGACGTTGACAGTACCGACACAACCGATTGGAGCACTGCGATGACTGACGCCAAGAA
CGCCGGGGTCACAATAGAAGTGACCGATGCTTCCTTTTTCGCAGACGTCTTATCCAGTAATAAGCCTGTGTTAGTTGATT
TTTGGGCAACATGGTGTGGACCCTGCAAGATGGTAGCGCCGGTACTCGAAGAGATCGCGTCCGAACAACGAAACCAGCTC
ACTGTCGCCAAGTTAGATGTAGACACCAACCCGGAAATGGCACGCGAGTTCCAGGTCGTGTCGATACCCACAATGATTCT
GTTCCAGGGTGGCCAACCAGTAAAACGCATCGTTGGCGCTAAGGGCAAAGCAGCGTTACTACGTGACCTTTCCGACGTGG
TACCTAACCTCAATTAG

Upstream 100 bases:

>100_bases
CAGGTGCGCATGTTGTTGGGACGCGCAGGATAACAGCAATGCCTACGCTGGTGTTCGTAACCATATTGCCGGATTAGCTT
GATGTACCTGAAAGGCTCGC

Downstream 100 bases:

>100_bases
ACTTAATGTAGTTCATGGCAAAACAGCCGTTGCTAGCCTGGGGTTTTCCTGAAACCGACAAGGATCTGCGACAATACCGA
TTAACTGCTGTGCATCTGTC

Product: bifunctional thioredoxin reductase/thioredoxin

Products: NA

Alternate protein names: Thioredoxin reductase; TRXR; Thioredoxin

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMREQALR
FGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMGTSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGG
GDSAMEEALFLTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTG
VFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSKA
NETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQL
TVAKLDVDTNPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN

Sequences:

>Translated_458_residues
MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMREQALR
FGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMGTSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGG
GDSAMEEALFLTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTG
VFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSKA
NETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQL
TVAKLDVDTNPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
>Mature_458_residues
MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMREQALR
FGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMGTSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGG
GDSAMEEALFLTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTG
VFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSKA
NETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQL
TVAKLDVDTNPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=38.1443298969072, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787114, Length=310, Percent_Identity=48.7096774193548, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87081763, Length=311, Percent_Identity=31.8327974276527, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=51.5789473684211, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788936, Length=82, Percent_Identity=39.0243902439024, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081747, Length=91, Percent_Identity=37.3626373626374, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789606, Length=340, Percent_Identity=28.2352941176471, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=93, Percent_Identity=34.4086021505376, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=95, Percent_Identity=40, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=90, Percent_Identity=32.2222222222222, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320560, Length=312, Percent_Identity=47.1153846153846, Blast_Score=283, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6321898, Length=313, Percent_Identity=44.0894568690096, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=46.5909090909091, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=93, Percent_Identity=46.2365591397849, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=101, Percent_Identity=34.6534653465347, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=102, Percent_Identity=38.2352941176471, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=38.75, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24664269, Length=92, Percent_Identity=39.1304347826087, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=40.5063291139241, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=40.5063291139241, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=41.9753086419753, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639068, Length=81, Percent_Identity=35.8024691358025, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRXB_MYCLE (P46843)

Other databases:

- EMBL:   L39923
- EMBL:   X87899
- EMBL:   AL583926
- PIR:   S77662
- RefSeq:   NP_302724.1
- ProteinModelPortal:   P46843
- EnsemblBacteria:   EBMYCT00000028083
- GeneID:   910819
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2703
- NMPDR:   fig|272631.1.peg.1596
- Leproma:   ML2703
- GeneTree:   EBGT00050000014577
- HOGENOM:   HBG669726
- OMA:   VMGAFIA
- ProtClustDB:   CLSK2460636
- BioCyc:   MLEP272631:ML2703-MONOMER
- BRENDA:   1.8.1.9
- GO:   GO:0005737
- GO:   GO:0006810
- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PRINTS:   PR00368
- PRINTS:   PR00469
- TIGRFAMs:   TIGR01068
- TIGRFAMs:   TIGR01292

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: =1.8.1.9

Molecular weight: Translated: 49047; Mature: 49047

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00573 PYRIDINE_REDOX_2; PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPG
CCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCCC
FRNGITGPELMDDMREQALRFGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHCCCCCCEEEEEEEEEEC
TSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTRFARSVTL
CCEEEEECCCHHHHHHCCCHHHEECCCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHHE
VHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTG
EEHHHHHHHHHEEEEECCCCCEEEEEECCEEEEECCCEEEEEEEEECCCCCCCEEEEEEE
VFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGS
EEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHCCC
GCAAAIDAERWLAEHAGSKANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFF
CCEEEHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEECHHHH
ADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQVV
HHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHEEEEE
SIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
EECEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPG
CCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCCC
FRNGITGPELMDDMREQALRFGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHCCCCCCEEEEEEEEEEC
TSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTRFARSVTL
CCEEEEECCCHHHHHHCCCHHHEECCCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHHE
VHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTG
EEHHHHHHHHHEEEEECCCCCEEEEEECCEEEEECCCEEEEEEEEECCCCCCCEEEEEEE
VFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGS
EEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHCCC
GCAAAIDAERWLAEHAGSKANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFF
CCEEEHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEECHHHH
ADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQVV
HHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHEEEEE
SIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
EECEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969512; 7476189; 11234002