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The map label for this gene is ytpA [H]

Identifier: 221230881

GI number: 221230881

Start: 3107415

End: 3108254

Strand: Direct

Name: ytpA [H]

Synonym: MLBr_02603

Alternate gene names: 221230881

Gene position: 3107415-3108254 (Clockwise)

Preceding gene: 221230879

Following gene: 221230882

Centisome position: 95.08

GC content: 59.88

Gene sequence:

>840_bases
ATGACTATCACTCGCACTGAGCGGAATTTTTACGGCGTCGGCGGCGTACGGATTGTCTATGACGTATGGATGCCGGACAC
GCGCCCGCGAGCGGTGATTATACTGGCCCACGGTTTCGGCGAGCATGCCCGCCGCTACGACCATGTCGCCCATTACTTTG
CCGCAGCGGGGTTGGCCACCTACGCGCTTGACCTCCGCGGACATGGACGTTCGGCCGGCAAACGAGTCCTGGTTCGAGAT
TTATCCGAGTACAACGCTGACTTCGACATCCTGGTCGGGATCGCCACCCGCGACCATCCTGGCCTCAAGCGCATCGTGGC
GGGGCACAGTATGGGTGGGGCGATCGTATTCGCTTACGGTGTAGAACGTCCAGACAATTACGACTTGATGGTGCTATCGG
GGCCAGCAGTGGCGGCCCAAGACATGGTGTCGCCGCTGCGCGCGGTGGTCGGCAAGGGGCTCGGACTCGTTGCACCCGGG
CTGCCCGTACATCAGCTTGAGGTCGATGCCATATCTCGGAATCGCGCGGTGGTAGCAGCCTACAAAGACGACCCGTTGGT
GTATCACGGCAAGGTCCCGGCTGGTGTTGGGCGCGTGATGTTGCAGGTCGGCGAAACTATGACCCGCCGGGCACCGGTGC
TGACCACGCCGTTACTGGTAGTGCACGGTTCAGAGGACCGGCTTGTTCTGGTCGACGGTAGCCACCGTTTGGTCGAATGT
GTGGGATCCACCGATGTCGAGTTGAAGGTCTACCCTGGATTATATCATGAGGTTTTCAATGAGCCGGAGCGTGACCAGGT
GCTCGAGGATGTGGTTTGCTGGATCTTGAAAAGGCTCTAA

Upstream 100 bases:

>100_bases
GCGCGTTCGGCATCAGAATTATCGGCGAAAAAACTCACCAACCCGCAAATTTACGCATGCTGTCTGACGTCTCATCCGGG
CAGCCGCTACGCTGCCCTTA

Downstream 100 bases:

>100_bases
CCGACGTAGTGGCAGTCACGTACGCAGAAATTGTCATACCACTCCACGTAGTTTGATGTTATGACCGACAACAAAATGCT
GGCCCGCATTGCCGCGTTGC

Product: hypothetical protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLATYALDLRGHGRSAGKRVLVRD
LSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYGVERPDNYDLMVLSGPAVAAQDMVSPLRAVVGKGLGLVAPG
LPVHQLEVDAISRNRAVVAAYKDDPLVYHGKVPAGVGRVMLQVGETMTRRAPVLTTPLLVVHGSEDRLVLVDGSHRLVEC
VGSTDVELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL

Sequences:

>Translated_279_residues
MTITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLATYALDLRGHGRSAGKRVLVRD
LSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYGVERPDNYDLMVLSGPAVAAQDMVSPLRAVVGKGLGLVAPG
LPVHQLEVDAISRNRAVVAAYKDDPLVYHGKVPAGVGRVMLQVGETMTRRAPVLTTPLLVVHGSEDRLVLVDGSHRLVEC
VGSTDVELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL
>Mature_278_residues
TITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLATYALDLRGHGRSAGKRVLVRDL
SEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYGVERPDNYDLMVLSGPAVAAQDMVSPLRAVVGKGLGLVAPGL
PVHQLEVDAISRNRAVVAAYKDDPLVYHGKVPAGVGRVMLQVGETMTRRAPVLTTPLLVVHGSEDRLVLVDGSHRLVECV
GSTDVELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=259, Percent_Identity=35.1351351351351, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI6005786, Length=259, Percent_Identity=35.1351351351351, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1787678, Length=273, Percent_Identity=24.9084249084249, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 30563; Mature: 30431

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLAT
CCEEECCCCEEECCCEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
YALDLRGHGRSAGKRVLVRDLSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYG
EEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCCCCEEEEEEE
VERPDNYDLMVLSGPAVAAQDMVSPLRAVVGKGLGLVAPGLPVHQLEVDAISRNRAVVAA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEEEECCCCEEEEE
YKDDPLVYHGKVPAGVGRVMLQVGETMTRRAPVLTTPLLVVHGSEDRLVLVDGSHRLVEC
ECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCEEEEECCCCCEEEEECCCEEEEE
VGSTDVELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL
CCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLAT
CEEECCCCEEECCCEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
YALDLRGHGRSAGKRVLVRDLSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYG
EEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCCCCEEEEEEE
VERPDNYDLMVLSGPAVAAQDMVSPLRAVVGKGLGLVAPGLPVHQLEVDAISRNRAVVAA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEEEECCCCEEEEE
YKDDPLVYHGKVPAGVGRVMLQVGETMTRRAPVLTTPLLVVHGSEDRLVLVDGSHRLVEC
ECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCEEEEECCCCCEEEEECCCEEEEE
VGSTDVELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL
CCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]