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The map label for this gene is aac [H]

Identifier: 221230849

GI number: 221230849

Start: 3039059

End: 3039607

Strand: Direct

Name: aac [H]

Synonym: MLBr_02551

Alternate gene names: 221230849

Gene position: 3039059-3039607 (Clockwise)

Preceding gene: 221230848

Following gene: 221230850

Centisome position: 92.99

GC content: 63.02

Gene sequence:

>549_bases
ATGGATACCCACCACGTACATACCGCCCGCCTGGTTCATACCGCCGATCTCGACGGCGAGACTCTCCGGCGCCTCCAGCA
GATGGTCACCGACGCTTTCGCCGGAGACTTCGACGAGACCGACTGGGAACACGCATTGGGCGGGATGCACGCCCTGATCT
GGCGGCACGGCACAATCATTGCGCACGCCGCGGTCGTTCAGCGGCGACTATTCTACCACGGCAACGCGTTGCGTTGCGGT
TACCTCGAAGGTGTCGCGGTACGGAAGGACTGCCGGGGCCGCGGACTTGTACATGCGCTGCTGGACGCTATCGAGCAAGT
GATACGCGGCGCCTATCAATTCGGTGCCTTGAGTTCCTCGGACCGAGCCCGTCGGGTGTATATGTCGCGCGGGTGGTTAC
CATGGCTCGGCCCGACGTCAGTGCTGGCTCCTACCGGTGTGATCCGTACGCCCGATGATGACGGCTCGGTGTTTGTCCTT
CCGGTCGGCATCAACCCGGACACCTCCTCGGGGTTGATGTGCGATTGGCGCGCAGGCAACGTGTGGTAA

Upstream 100 bases:

>100_bases
GTAAGGACCCAGTCGTCGCCACTGGAACGACTACGGTCCGCGTCCCAGAACTGACTGTTCTAGTAACACCAACCCGGTAG
ATAAAGCCTGGTAAACTACT

Downstream 100 bases:

>100_bases
CTTGGATGGTAAGTATGTTTGGATTGTCATGGCCGCTTCTGCGTACGGACCCCGCCACTCATATCCGAGATGTTCAAGCG
AACCTACAGTGGCAAACTGG

Product: aminoglycoside 2'-N-acetyltransferase

Products: NA

Alternate protein names: AAC(2')-Ic [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MDTHHVHTARLVHTADLDGETLRRLQQMVTDAFAGDFDETDWEHALGGMHALIWRHGTIIAHAAVVQRRLFYHGNALRCG
YLEGVAVRKDCRGRGLVHALLDAIEQVIRGAYQFGALSSSDRARRVYMSRGWLPWLGPTSVLAPTGVIRTPDDDGSVFVL
PVGINPDTSSGLMCDWRAGNVW

Sequences:

>Translated_182_residues
MDTHHVHTARLVHTADLDGETLRRLQQMVTDAFAGDFDETDWEHALGGMHALIWRHGTIIAHAAVVQRRLFYHGNALRCG
YLEGVAVRKDCRGRGLVHALLDAIEQVIRGAYQFGALSSSDRARRVYMSRGWLPWLGPTSVLAPTGVIRTPDDDGSVFVL
PVGINPDTSSGLMCDWRAGNVW
>Mature_182_residues
MDTHHVHTARLVHTADLDGETLRRLQQMVTDAFAGDFDETDWEHALGGMHALIWRHGTIIAHAAVVQRRLFYHGNALRCG
YLEGVAVRKDCRGRGLVHALLDAIEQVIRGAYQFGALSSSDRARRVYMSRGWLPWLGPTSVLAPTGVIRTPDDDGSVFVL
PVGINPDTSSGLMCDWRAGNVW

Specific function: Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. It confers resistance to aminoglycosides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181 [H]

Pfam domain/function: PF00583 Acetyltransf_1 [H]

EC number: NA

Molecular weight: Translated: 20169; Mature: 20169

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTHHVHTARLVHTADLDGETLRRLQQMVTDAFAGDFDETDWEHALGGMHALIWRHGTII
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHH
AHAAVVQRRLFYHGNALRCGYLEGVAVRKDCRGRGLVHALLDAIEQVIRGAYQFGALSSS
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DRARRVYMSRGWLPWLGPTSVLAPTGVIRTPDDDGSVFVLPVGINPDTSSGLMCDWRAGN
CHHHHHHHHCCCCCCCCCCHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCEEEECCCCC
VW
CC
>Mature Secondary Structure
MDTHHVHTARLVHTADLDGETLRRLQQMVTDAFAGDFDETDWEHALGGMHALIWRHGTII
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHH
AHAAVVQRRLFYHGNALRCGYLEGVAVRKDCRGRGLVHALLDAIEQVIRGAYQFGALSSS
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DRARRVYMSRGWLPWLGPTSVLAPTGVIRTPDDDGSVFVLPVGINPDTSSGLMCDWRAGN
CHHHHHHHHCCCCCCCCCCHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCEEEECCCCC
VW
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]