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The map label for this gene is 221230738

Identifier: 221230738

GI number: 221230738

Start: 2779402

End: 2781600

Strand: Reverse

Name: 221230738

Synonym: MLBr_02341

Alternate gene names: NA

Gene position: 2781600-2779402 (Counterclockwise)

Preceding gene: 221230739

Following gene: 221230736

Centisome position: 85.11

GC content: 62.07

Gene sequence:

>2199_bases
ATGACGACGGCGTTGGTCTGCGTGGCGTGCGGCGCAGAATTGCGGTCGATCGCGAAGTTCTGCGATGAGTGCGGCTCACC
GGTTGTCGAGGCCGAAACACCCGCAGAGTACAAGCAGGTGACGGTTTTGTTCGCCGACGTGGTGGGTTCGATGGATATCG
CGGCAGCGGTCGGTTTGGAACGGCTGCGCGAAATCATGACCGAGCTGGTCAGCCGCGCCGCGGGGGTGATCGAGCGTTAT
GGCGGCACGGTGGACAAGTTCACTGGCGACGGCATCATGGCTATCTTTGGTGCGCCGACGGCGTTGGAGGATCATGCGTT
GCGCGCGTGTTTAGCCGCGCTTGGTGTCCAAGAAAAGGCTAGGCGGCTGGCGGCCGAGGTTGGTGATCGTGACGGTGTTG
ATCTTCAGCTGCGGGTGGGCCTGAATTCCGGTCAGGTTATTGTTGGTGAAATTGGTTCTAGCGCTTTGGGGTACACCGCT
GTTGGTGTGCAGGTGGGGATGGCCCAGAGGATGGAGTCGGTTGCGCCGCCGGGCGTGGTGATGCTCAGCGAATCCACCGC
ACGGCTGGTGGAGCAGACCGCAGTGTTGGGTGCACCGCAGACGGTGCGCATCAAGGGCGCCGAGGATGCGGTGCCTGCGC
GGCGACTGCTACGCGTAGCCGAGCCGCGCCAGCCGACGTGGTTCTCGGAGTCGACGTTGGTGGGTCGCGAGTGGGAATTG
GCCACGCTGGCGGCGATGCTCGATCGATCGATCGGTGGGCGGGGCTCGGTGGTGGGGCTGGTTGGTCCTGCTGGCATAGG
GAAGACACGACTCGTCGCCGAAGCTGTGCAGCTCGCGAAAGGTCTTGAAGTCGAGGTGTTTTCCGTTTTCTGTGAATCGC
ACGCCACCGATGTCGCGTTCGATGTGGTGGCCCAGCTGGTGCGTGCCGTGGCGCAGATCAGCGGTCTCGATGATCGCAGT
GCGCGGGCCCGTGTGCGGGAGCAGATTCCTGACGCCGATACGCAGGATCTTTTGCTCCTTGACGACTTGTTGGGCATTGC
CGATCCCGCGGTGGAGCTGCCCAGGCTAGACCCGGATGCGCGGCGGCGGCGGTTGACTGCGCTGATCAACGTCGCCCAGT
TGGCCTTGAGCCGACCAGCGGTCTTTGTGGTGGAGGATGTTCACTGGATTGACGAGGTCAGCGACTCCATGCTGGCCGAC
TTTTTGGCGGTGATACCTCAAACCCGGTCGATGGCACTGGTCACATATCGCCCCGAGTACCACGGAGCCTTGCGCCATGT
TGTTGGAGCACAGATCATTGCTGTCGCACCCCTGAGCGATGTTGAGACCTCAACGCTGGTTGCTGAGCTGTTAGGTCTCG
ATCAATCCGTTACCCAGATCGGCGAACTTATCACCGAGCGCGCGGCAGGTAATCCCTTCTTTGCCCAGGAGATCACTCGA
GAGCTCGCTGAACGTGGTGTTCTGACAGGTGAGCGCGGCCGGTACGCTTGCAGCACTGATGTGGCCGAAGTCTGCGTGCC
AGCTACCCTGCAGGCGACTATAGCTGCCCGCATCGACCGTCTTAGTCCGCCTGCCAAACAGCTGCTTGTTGCCGCGGCAG
TTATCGGGTTTCGCTTCGGCTCCGATCTGCTGGCCAGCTTGGGAATCGATCTTAGCGTCGATGAACTGATCGATGCCAAC
CTCGTCGACCAGGTGCGGTTTACCGCGCCCGTCGAGTATGCGTTTCGGCATCCGCTGATTCGTACCGTAGCCTACGAATC
ACAACTGAAATCCGATCGGGCCCGGTTGCATCGGCGGCTGGCCGCTGCGATCGAAGCGCGTGCCCCACACTCGGTCGATC
AGCACGCGGTGCTGATTGCCGAGCATTTGGAGGCCGCCGGTGATTTGCACGCCGCGTACGGCTGGCACATGCGCGCCGCA
GCATGGGCCACTAATCAGGACGTCCGCGCGGCGCGAGTGAGTTGGGAACACGCCACAAAGATCGCTGACGCACTAACTGC
CGAAGATCCGCACCGAGCTGCGATGTGCATTGCTCCTCGAACCAGGTTGTGTGGCATCGCTTGGCGAGGGCGTTTCAATT
CTAGCTCCGGTTTTGATGAAGTGCGTCAGCTGTGCAACGCCACTGGGGACAAGGCTCCGCTGGCCGTGGCCACGGTGGGG
CCGGCGATCGACCACGTGTATCAGGACCGGTTGCACTAG

Upstream 100 bases:

>100_bases
AATTGCGCTAACTGACCATGAACAGCGTCAATGTCCGGCGTTTGGTGCGTTGCCCTGGGATAATACGAAAACTCTGGGAC
CGTGCGGGGCGGACAGGCGG

Downstream 100 bases:

>100_bases
GCGTCGTAGTTGGCTTCTGCAGCCAATGGCCATCATTGAGTTGCTCGAGGAGCGGATTCTGGATTGTGGGGCTGTCCTGA
TGGCAACAGATTTATGCAAA

Product: putative regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MTTALVCVACGAELRSIAKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMTELVSRAAGVIERY
GGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTA
VGVQVGMAQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWEL
ATLAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLDDRS
ARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLAD
FLAVIPQTRSMALVTYRPEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITR
ELAERGVLTGERGRYACSTDVAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVDELIDAN
LVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMRAA
AWATNQDVRAARVSWEHATKIADALTAEDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVATVG
PAIDHVYQDRLH

Sequences:

>Translated_732_residues
MTTALVCVACGAELRSIAKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMTELVSRAAGVIERY
GGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTA
VGVQVGMAQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWEL
ATLAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLDDRS
ARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLAD
FLAVIPQTRSMALVTYRPEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITR
ELAERGVLTGERGRYACSTDVAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVDELIDAN
LVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMRAA
AWATNQDVRAARVSWEHATKIADALTAEDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVATVG
PAIDHVYQDRLH
>Mature_731_residues
TTALVCVACGAELRSIAKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMTELVSRAAGVIERYG
GTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAV
GVQVGMAQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWELA
TLAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLDDRSA
RARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLADF
LAVIPQTRSMALVTYRPEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITRE
LAERGVLTGERGRYACSTDVAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVDELIDANL
VDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMRAAA
WATNQDVRAARVSWEHATKIADALTAEDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVATVGP
AIDHVYQDRLH

Specific function: Unknown

COG id: COG3899

COG function: function code R; Predicted ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI148536830, Length=150, Percent_Identity=31.3333333333333, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557255, Length=156, Percent_Identity=27.5641025641026, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI24497587, Length=154, Percent_Identity=29.8701298701299, Blast_Score=72, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=166, Percent_Identity=27.710843373494, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86564713, Length=159, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=166, Percent_Identity=27.710843373494, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=158, Percent_Identity=29.746835443038, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646197, Length=161, Percent_Identity=27.3291925465839, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI161078020, Length=153, Percent_Identity=30.718954248366, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583980, Length=147, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921208, Length=152, Percent_Identity=28.2894736842105, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583976, Length=147, Percent_Identity=30.6122448979592, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330468, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221330470, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011579 [H]

Pfam domain/function: PF01637 Arch_ATPase; PF00211 Guanylate_cyc [H]

EC number: NA

Molecular weight: Translated: 78380; Mature: 78249

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTALVCVACGAELRSIAKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLE
CCCCCCHHHCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
RLREIMTELVSRAAGVIERYGGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQEKA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCHHHHH
RRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGVQVGMAQRMESVAPPGVV
HHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
MLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWEL
EECCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
ATLAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQLAKGLEVEVFSVFCESHATDVAF
HHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
DVVAQLVRAVAQISGLDDRSARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHH
RRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYRPEY
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHH
HGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITR
HHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
ELAERGVLTGERGRYACSTDVAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFG
HHHHCCCCCCCCCCEEECCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SDLLASLGIDLSVDELIDANLVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRL
HHHHHHCCCCCCHHHHHCCHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
AAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMRAAAWATNQDVRAARVSWEHATK
HHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHH
IADALTAEDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVATVG
HHHHHCCCCCCCCEEEECCCHHHCCEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECC
PAIDHVYQDRLH
HHHHHHHHHCCC
>Mature Secondary Structure 
TTALVCVACGAELRSIAKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLE
CCCCCHHHCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
RLREIMTELVSRAAGVIERYGGTVDKFTGDGIMAIFGAPTALEDHALRACLAALGVQEKA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCHHHHH
RRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGVQVGMAQRMESVAPPGVV
HHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
MLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWEL
EECCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
ATLAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQLAKGLEVEVFSVFCESHATDVAF
HHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
DVVAQLVRAVAQISGLDDRSARARVREQIPDADTQDLLLLDDLLGIADPAVELPRLDPDA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHH
RRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYRPEY
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHH
HGALRHVVGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITR
HHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
ELAERGVLTGERGRYACSTDVAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFG
HHHHCCCCCCCCCCEEECCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SDLLASLGIDLSVDELIDANLVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRL
HHHHHHCCCCCCHHHHHCCHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
AAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMRAAAWATNQDVRAARVSWEHATK
HHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHH
IADALTAEDPHRAAMCIAPRTRLCGIAWRGRFNSSSGFDEVRQLCNATGDKAPLAVATVG
HHHHHCCCCCCCCEEEECCCHHHCCEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECC
PAIDHVYQDRLH
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]