Click here to switch to the map view.

The map label for this gene is pon1 [H]

Identifier: 221230717

GI number: 221230717

Start: 2732112

End: 2734523

Strand: Direct

Name: pon1 [H]

Synonym: MLBr_02308

Alternate gene names: 221230717

Gene position: 2732112-2734523 (Clockwise)

Preceding gene: 221230715

Following gene: 221230718

Centisome position: 83.6

GC content: 61.24

Gene sequence:

>2412_bases
ATGTCAGAGCGCCTCCCAGCCGTCCTCGCAGTTCTCAAGCTTGCGGGGTATTGCCTATTGGCCGGCGTTGTCACCACCGC
AATGATGTTCCCGTTGGCCGGCGGACTGGGGGTGATATCCAACCGTGCTTCGGAAGTGGTAGCCAACGGATCGGCCCAAC
TTCTCGAGGGCGAGGTGCCCGCGGTATCGACAATGGTCGACGCGAAGGGAAACACGATCGCGTGGCTGTACTCGCAACGC
CGATTCGAGGTACCCACCGACAAGATCGCCAACACCATGAAGCTGGCCATCGTTTCCATCGAGGATAAACGCTTTACCGA
CCACAACGGTGTGGACTGGCCGGGCACCCTGACCGGACTGGCCGGCTACGCATCCGGCGACGTGGACACTCGCGGCGGTT
CGACGATCGAGCAGCAGTACGTGAAAAACTATCAGTTACTGGTAACCGCTCAAACCGACGCCGAAAAACGTGCGGCCGTC
GAAACCACCCCGGCACGCAAGCTGCGCGAGATCCGGATAGCGCTCACGCTGGACAAGACGTTCACCAAACCCGAGATCCT
GACCCGCTACTTGAACCTGGTGTCGTTCGGCAACAACTCTTTCGGCGTGCAAGATGCAGCGCAGACCTACTTCGGCGTCA
ACGCGTCCGACCTAAATTGGCAACAAGCAGCACTACTCGCCGGCATGGTGCAATCGACCAGCACGCTCAACCCGTACACC
AACCCTGAAGGCGCGTTGGCCCGGCGAAACTTGGTGCTGGACACCATGATCGAAAACCTACCGCAGGACGCCGAGGCACT
GCGCGCCGCCAAGACTGAGCCGCTGGGGATATTGCCACGGCCCAACGAGCTGCCTCGGGGCTGCATCGCGGCAGGCGACC
GAGCATTCTTCTGCGACTATGTCCAGGAGTATTTGTCCCACGCCGGGATCAGCAAAGATCGGCTAGCCAAGGGCGGCTAC
CTCATCCGCACCACTCTTGACCCTAACGTCCAAGCCCCGGTCAAAGCGGCCATCGACAAGTTCGCCAGCCCAAACCTGGC
GGGCATCTCCAGTGTGATGAGCGTAATCACCCCGGGCAAAGATGCCCATCGCGTGATCGCGATGGGCAGCAACCGCAGAT
ACGGGCTAGACACCGAGGCCGGTGAAACCATGCGACCACAGACATTTTCCCTGGTCGGCGACGGGGCTGGGTCGGTCTTC
AAGATCTTCACCACGGCCGCCGCACTGGACATGGGGATGGGCATCAACGCCAAACTCGAGGTTCCGAGCCGGTTCCAGGC
CAAAGGGATGGGAAGCGGCGGAGCCAAGGGGTGCCCTAAGGAAACCTGGTGCGTGATCAACGCCGGTAATTACCGAGGGT
CGATGAACGTCACCGACGCCCTAGCCACCTCACCCAACACCGCATTCGCCAAGCTGATCCAGCAAGTCGGGGTGGCGCGC
ACGGTGGACATGGCGATCAAACTCGGGTTGCGGTCCTATACAACCCCCGGCACAGCCCGCGACTATAATCCGGACAGCAA
CGAAAGCTTAGCCGACTTCGTAAAACGGCAGAACATCGGTTCGTTCACCCTGGGCCCGATCAAGGTCAACGCGCTGGAGT
TATCGAATGTCGCGGCGACGCTGGCATCGGGTGGGATGTGGTGCCCGCCGAACCCAATTGACAAACTGTTCGACCGTAAC
GGCAACGAAGTTGCCGTTACGGTCGAGACCTGCGATCGGGTGGTGCCCGAGGGTTTGGCCAACACGTTGGCCAACGCAAT
GAGCAAAGACACAAAGGGCAGCGGCACCGCGGCCGGTTCTGCCGGTGCAGCAGGCTGGGATCTACCAATGTCAGGCAAAA
CTGGCACCACAGAAGCCCACCGATCCTCCGGCTTCGTAGGTTTCACCAACCACTACGCAGCGGCCAACTATATCTACGAC
GATTCCACCTCGCCAACGAATCTGTGCTCCGGTCCACTGCGGCACTGCAGCAACGGTGACTTATACGGCGGTAACGAGCC
AGCCCGAACCTGGTTCACCGCGATGAAGCCGATCGCCACCAAATTCGGTGAAGTCCGCTTGCCACCGACCGATCCGCGCT
ACGTCGACGGTTCTCCCGGTTCACAGGTGCCAAGCGTGACCGGACTGGACCTGGACGCGGCGCGCCAGCGCCTGAAGGGG
GCAGGTTTCCAGGTTGCCGATCAGCCCACCTTGATCAACAGCACCGCCAAGCTCGGCGCAGTGGTCGGCACCACACCCAG
CGGCCAAACAATTCCGGGTTCGATCATTACAATTCAAACCAGCAGCGGCATACCGCCGGCTCCGCCACCGCCGCCGGAAG
GCGGCCCGCCGATGCCACCCTCGGTTGGATCGCAGGTCATCGAAATTCCCGGCTTGCCGCCAATCACCATTCCGCTACTA
GCGCCTCCGTAA

Upstream 100 bases:

>100_bases
TTCGGTGCTGATCATCGACAAAGTTGCTGATAACCAGTCGCTCAAGATTTCTATGCGACTTCACTGCTAGTCGCCACAAC
TGGGGGCTACCGTAGTACAC

Downstream 100 bases:

>100_bases
ACCCGCAAAGGGCGCTTTGCCAACGGACTTGCGTTGTCTTGTCGGTCCGAGACTAACAGTAGGCTGCTTGCATGGCTGAC
ACACGCCTGACTACCCCACT

Product: penicillin binding protein (class A)

Products: NA

Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MSERLPAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRASEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQR
RFEVPTDKIANTMKLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKNYQLLVTAQTDAEKRAAV
ETTPARKLREIRIALTLDKTFTKPEILTRYLNLVSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYT
NPEGALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGDRAFFCDYVQEYLSHAGISKDRLAKGGY
LIRTTLDPNVQAPVKAAIDKFASPNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVGDGAGSVF
KIFTTAAALDMGMGINAKLEVPSRFQAKGMGSGGAKGCPKETWCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVAR
TVDMAIKLGLRSYTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLASGGMWCPPNPIDKLFDRN
GNEVAVTVETCDRVVPEGLANTLANAMSKDTKGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYD
DSTSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDPRYVDGSPGSQVPSVTGLDLDAARQRLKG
AGFQVADQPTLINSTAKLGAVVGTTPSGQTIPGSIITIQTSSGIPPAPPPPPEGGPPMPPSVGSQVIEIPGLPPITIPLL
APP

Sequences:

>Translated_803_residues
MSERLPAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRASEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQR
RFEVPTDKIANTMKLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKNYQLLVTAQTDAEKRAAV
ETTPARKLREIRIALTLDKTFTKPEILTRYLNLVSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYT
NPEGALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGDRAFFCDYVQEYLSHAGISKDRLAKGGY
LIRTTLDPNVQAPVKAAIDKFASPNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVGDGAGSVF
KIFTTAAALDMGMGINAKLEVPSRFQAKGMGSGGAKGCPKETWCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVAR
TVDMAIKLGLRSYTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLASGGMWCPPNPIDKLFDRN
GNEVAVTVETCDRVVPEGLANTLANAMSKDTKGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYD
DSTSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDPRYVDGSPGSQVPSVTGLDLDAARQRLKG
AGFQVADQPTLINSTAKLGAVVGTTPSGQTIPGSIITIQTSSGIPPAPPPPPEGGPPMPPSVGSQVIEIPGLPPITIPLL
APP
>Mature_802_residues
SERLPAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRASEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRR
FEVPTDKIANTMKLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKNYQLLVTAQTDAEKRAAVE
TTPARKLREIRIALTLDKTFTKPEILTRYLNLVSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYTN
PEGALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGDRAFFCDYVQEYLSHAGISKDRLAKGGYL
IRTTLDPNVQAPVKAAIDKFASPNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVGDGAGSVFK
IFTTAAALDMGMGINAKLEVPSRFQAKGMGSGGAKGCPKETWCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVART
VDMAIKLGLRSYTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLASGGMWCPPNPIDKLFDRNG
NEVAVTVETCDRVVPEGLANTLANAMSKDTKGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDD
STSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDPRYVDGSPGSQVPSVTGLDLDAARQRLKGA
GFQVADQPTLINSTAKLGAVVGTTPSGQTIPGSIITIQTSSGIPPAPPPPPEGGPPMPPSVGSQVIEIPGLPPITIPLLA
PP

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=307, Percent_Identity=29.6416938110749, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1786343, Length=589, Percent_Identity=24.2784380305603, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1789601, Length=177, Percent_Identity=35.5932203389831, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788867, Length=453, Percent_Identity=25.3863134657837, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 84512; Mature: 84381

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERLPAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRASEVVANGSAQLLEGEVP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCHHEECCCCC
AVSTMVDAKGNTIAWLYSQRRFEVPTDKIANTMKLAIVSIEDKRFTDHNGVDWPGTLTGL
CCCEEECCCCCEEEEEEECCCCCCCHHHHCCEEEEEEEEEECCCCCCCCCCCCCCHHHHH
AGYASGDVDTRGGSTIEQQYVKNYQLLVTAQTDAEKRAAVETTPARKLREIRIALTLDKT
CCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCHHHHHCCCCHHHHHEEEEEEEEECCC
FTKPEILTRYLNLVSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYT
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NPEGALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGDRAFFCDY
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHHHH
VQEYLSHAGISKDRLAKGGYLIRTTLDPNVQAPVKAAIDKFASPNLAGISSVMSVITPGK
HHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
DAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVGDGAGSVFKIFTTAAALDMGMGINAKLE
CCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEC
VPSRFQAKGMGSGGAKGCPKETWCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVAR
CCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHH
TVDMAIKLGLRSYTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAAT
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCEEEEEEEHHHHHHH
LASGGMWCPPNPIDKLFDRNGNEVAVTVETCDRVVPEGLANTLANAMSKDTKGSGTAAGS
HHCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDSTSPTNLCSGPLRHCSNGD
CCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCEEEEEEECCCCCCHHHCCHHHHHCCCCC
LYGGNEPARTWFTAMKPIATKFGEVRLPPTDPRYVDGSPGSQVPSVTGLDLDAARQRLKG
CCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHCC
AGFQVADQPTLINSTAKLGAVVGTTPSGQTIPGSIITIQTSSGIPPAPPPPPEGGPPMPP
CCCEECCCCCEECCHHHHCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
SVGSQVIEIPGLPPITIPLLAPP
CCCCCEEECCCCCCEEEECCCCC
>Mature Secondary Structure 
SERLPAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRASEVVANGSAQLLEGEVP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCHHEECCCCC
AVSTMVDAKGNTIAWLYSQRRFEVPTDKIANTMKLAIVSIEDKRFTDHNGVDWPGTLTGL
CCCEEECCCCCEEEEEEECCCCCCCHHHHCCEEEEEEEEEECCCCCCCCCCCCCCHHHHH
AGYASGDVDTRGGSTIEQQYVKNYQLLVTAQTDAEKRAAVETTPARKLREIRIALTLDKT
CCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCHHHHHCCCCHHHHHEEEEEEEEECCC
FTKPEILTRYLNLVSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYT
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NPEGALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGDRAFFCDY
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHHHH
VQEYLSHAGISKDRLAKGGYLIRTTLDPNVQAPVKAAIDKFASPNLAGISSVMSVITPGK
HHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
DAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVGDGAGSVFKIFTTAAALDMGMGINAKLE
CCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEC
VPSRFQAKGMGSGGAKGCPKETWCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVAR
CCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHH
TVDMAIKLGLRSYTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAAT
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCEEEEEEEHHHHHHH
LASGGMWCPPNPIDKLFDRNGNEVAVTVETCDRVVPEGLANTLANAMSKDTKGSGTAAGS
HHCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDSTSPTNLCSGPLRHCSNGD
CCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCEEEEEEECCCCCCHHHCCHHHHHCCCCC
LYGGNEPARTWFTAMKPIATKFGEVRLPPTDPRYVDGSPGSQVPSVTGLDLDAARQRLKG
CCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHCC
AGFQVADQPTLINSTAKLGAVVGTTPSGQTIPGSIITIQTSSGIPPAPPPPPEGGPPMPP
CCCEECCCCCEECCHHHHCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
SVGSQVIEIPGLPPITIPLLAPP
CCCCCEEECCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA