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The map label for this gene is degP [H]

Identifier: 221230707

GI number: 221230707

Start: 2722902

End: 2724107

Strand: Reverse

Name: degP [H]

Synonym: MLBr_02298

Alternate gene names: 221230707

Gene position: 2724107-2722902 (Counterclockwise)

Preceding gene: 221230708

Following gene: 221230704

Centisome position: 83.36

GC content: 62.11

Gene sequence:

>1206_bases
ATGAGTTCGATGACTCTGTCGGAGTGGCTGGATATCGCTGTTCTAGCGGTCGCGTTCATCGCTGCCATTTCGGGCTGGCG
TTCGGGCGCGTTGGGGTCTCTGCTGTCGTTAATCGGCGTACTGTTCGGCGCAATGGCGGGCGTGCTGCTGGTGCCGCACG
TCGTTAGCCACATCAGTGCTCCGCGCGCCAAATTATTCGCCGCCCTTTTTCTGATCCTCGCATTGGTTGTGATTGGTGAA
GTCGTCGGTGTGGTGCTGGGACGTGCGGTGCGCAGCGCGAACCGCAGCCGGACAGTGCGATTGGTTGACTCGGTCATTGG
GGTTGGGGTTCAGCTCATTGTAGTGCTGACCGCGGCTTGGCTGTTGGCGACACCGCTGACCCAGTCGAAAGAGCAGCCAG
AGCTGGCCTCCGCGGTCCGGGGTTCGCGGGCGCTCGCTTCAGTCAATGAGGTCGCGCCACCCTGGCTGAAGACGGTGCCT
AAGCGGCTCTCGGCGCTGCTGAATACGTCTGGTCTGCCTGCAGTGCTAGAGCCGTTCAGCCGCACCCCGGTCCTTCCAGT
CGCGTCGCCGGACCCGGCGTTGGTCGACAATCCGGTGGTGCTGGCGACCCAACCCAGTGTGGTTAAGATCCGCAGTGTGG
CGCCCAGCTGTCAGAAAGTGTTGGAGGGAACTGGATTCGTGGTATCGCTCGATCGGGTGATGACCAACGCACACGTGGTG
GCCGGGTCCGACGGTGTGCAGGTGTACGCCAGCGGCAATCCGTTTGACGCCACCGTGGTGTCCTACGACCCGTCGGTCGA
TATCGCTATCCTAGCTGTCCCGCATTTGCCGCCTGCGCCGCTGCGCTTCGACGACACTAAGGCCAAGCCGGGCACCAACG
TGGTGATGCTGGGGTATCCCGGCGGCGGTAACTTCACCGCAACCTCGGCCAGGATTCGCCAGGCCATCAAACTCACCGGA
CCCGACATCTACCGAGGTCTGGCGCCGGTCACCCGCGACGTGTACACTATCAGAGCTACTGTGGAACAAGGCAATTCAGG
TGGACCACTGATCGACCTTAATGGTCGGGTGCTTGGTGTGGTGTTCGGTGCGGCTGTCGATGATTCCGAAACTGGTTTCG
TGTTGACGGCTGAGGAAGTGTCCCACCGGCTTACCGAAATCGGTGAGACCCAGGAGGCGGTGGCCACTGGGGCCTGCGTC
AGCTGA

Upstream 100 bases:

>100_bases
CGATGCTCGACGTCGCCGGCTGGGCTCAATCCTGGGACGTCACCGACGTTCGCGAGGTGGGCGAGGCGATGGCGCTGGTC
GATAGTCAGGGAGATCCGCG

Downstream 100 bases:

>100_bases
GCCGGGGCCCGTGAACCTGCTTGAGAAACCGCGTCAGGTATCTGTTAATTTCCTCTGGTGCTTCTTCGTGACTGAAATGT
CCTGCGTCGGAAACGGATAC

Product: putative membrane-associated serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGVLLVPHVVSHISAPRAKLFAALFLILALVVIGE
VVGVVLGRAVRSANRSRTVRLVDSVIGVGVQLIVVLTAAWLLATPLTQSKEQPELASAVRGSRALASVNEVAPPWLKTVP
KRLSALLNTSGLPAVLEPFSRTPVLPVASPDPALVDNPVVLATQPSVVKIRSVAPSCQKVLEGTGFVVSLDRVMTNAHVV
AGSDGVQVYASGNPFDATVVSYDPSVDIAILAVPHLPPAPLRFDDTKAKPGTNVVMLGYPGGGNFTATSARIRQAIKLTG
PDIYRGLAPVTRDVYTIRATVEQGNSGGPLIDLNGRVLGVVFGAAVDDSETGFVLTAEEVSHRLTEIGETQEAVATGACV
S

Sequences:

>Translated_401_residues
MSSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGVLLVPHVVSHISAPRAKLFAALFLILALVVIGE
VVGVVLGRAVRSANRSRTVRLVDSVIGVGVQLIVVLTAAWLLATPLTQSKEQPELASAVRGSRALASVNEVAPPWLKTVP
KRLSALLNTSGLPAVLEPFSRTPVLPVASPDPALVDNPVVLATQPSVVKIRSVAPSCQKVLEGTGFVVSLDRVMTNAHVV
AGSDGVQVYASGNPFDATVVSYDPSVDIAILAVPHLPPAPLRFDDTKAKPGTNVVMLGYPGGGNFTATSARIRQAIKLTG
PDIYRGLAPVTRDVYTIRATVEQGNSGGPLIDLNGRVLGVVFGAAVDDSETGFVLTAEEVSHRLTEIGETQEAVATGACV
S
>Mature_400_residues
SSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGVLLVPHVVSHISAPRAKLFAALFLILALVVIGEV
VGVVLGRAVRSANRSRTVRLVDSVIGVGVQLIVVLTAAWLLATPLTQSKEQPELASAVRGSRALASVNEVAPPWLKTVPK
RLSALLNTSGLPAVLEPFSRTPVLPVASPDPALVDNPVVLATQPSVVKIRSVAPSCQKVLEGTGFVVSLDRVMTNAHVVA
GSDGVQVYASGNPFDATVVSYDPSVDIAILAVPHLPPAPLRFDDTKAKPGTNVVMLGYPGGGNFTATSARIRQAIKLTGP
DIYRGLAPVTRDVYTIRATVEQGNSGGPLIDLNGRVLGVVFGAAVDDSETGFVLTAEEVSHRLTEIGETQEAVATGACVS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=178, Percent_Identity=33.7078651685393, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4506141, Length=145, Percent_Identity=33.7931034482759, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41589; Mature: 41458

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGVLLVPHVVSHISA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRAKLFAALFLILALVVIGEVVGVVLGRAVRSANRSRTVRLVDSVIGVGVQLIVVLTAAW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATPLTQSKEQPELASAVRGSRALASVNEVAPPWLKTVPKRLSALLNTSGLPAVLEPFS
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCC
RTPVLPVASPDPALVDNPVVLATQPSVVKIRSVAPSCQKVLEGTGFVVSLDRVMTNAHVV
CCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHCCCCEEEEHHHHHCCCEEE
AGSDGVQVYASGNPFDATVVSYDPSVDIAILAVPHLPPAPLRFDDTKAKPGTNVVMLGYP
ECCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEC
GGGNFTATSARIRQAIKLTGPDIYRGLAPVTRDVYTIRATVEQGNSGGPLIDLNGRVLGV
CCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEECCEEEEE
VFGAAVDDSETGFVLTAEEVSHRLTEIGETQEAVATGACVS
EEECEECCCCCCEEEEHHHHHHHHHHHCCHHHHHHCCCCCC
>Mature Secondary Structure 
SSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGVLLVPHVVSHISA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRAKLFAALFLILALVVIGEVVGVVLGRAVRSANRSRTVRLVDSVIGVGVQLIVVLTAAW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATPLTQSKEQPELASAVRGSRALASVNEVAPPWLKTVPKRLSALLNTSGLPAVLEPFS
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCC
RTPVLPVASPDPALVDNPVVLATQPSVVKIRSVAPSCQKVLEGTGFVVSLDRVMTNAHVV
CCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHCCCCEEEEHHHHHCCCEEE
AGSDGVQVYASGNPFDATVVSYDPSVDIAILAVPHLPPAPLRFDDTKAKPGTNVVMLGYP
ECCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEC
GGGNFTATSARIRQAIKLTGPDIYRGLAPVTRDVYTIRATVEQGNSGGPLIDLNGRVLGV
CCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCCEEEECCEEEEE
VFGAAVDDSETGFVLTAEEVSHRLTEIGETQEAVATGACVS
EEECEECCCCCCEEEEHHHHHHHHHHHCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]