Click here to switch to the map view.

The map label for this gene is purQ

Identifier: 221230667

GI number: 221230667

Start: 2635930

End: 2636604

Strand: Reverse

Name: purQ

Synonym: MLBr_02219

Alternate gene names: 221230667

Gene position: 2636604-2635930 (Counterclockwise)

Preceding gene: 221230668

Following gene: 221230666

Centisome position: 80.68

GC content: 60.59

Gene sequence:

>675_bases
GTGAACGCGCGGATCGGTGTTATCACCTTTCCGGGGACACTTGACGACGTGGATGCCGCACGCGCGGCGCGCCATGTCGG
AGCCGAGGCGGTCAGCCTGTGGCATGCTGACGCCGACCTCAAGGGTGTCGACGCTGTGGTGGTACCCGGCGGGTTTTCCT
ATGGTGACTACCTGCGGGCCGGTGCGATCGCTAGATTATCCCCGATAATGACTGAGGTTGTCGATGCCGTGCAGCGCGGC
ATGCCGGTATTGGGAATCTGCAACGGTTTTCAGGTGCTCTGTGAGGCGGGCCTGCTGCCGGGAGCCCTGATACGCAACGT
GGGGTTGCATTTCATCTGTCGCGACGTGTGGTTGCGGGTGATATCGACCTCGACGGCGTGGACATCGCGTTTCGAGCCCG
AGACTGATCTGTTGGTATCGTTGAAGTCCGGCGAAGGACGTTACGTGGCATCCGAGAACGTGCTCGATGAGTTAGATGGT
GAGGGCCGGGTGGTGTTCCGCTATCACGACAACATCAACGGCTCACTGCGCGATATCGCGGGCATTAGCTCAGCTAATGG
CAGGGTCGTCGGGATGATGCCGCATCCCGAGCATGCCATCGAAGTGTTGACCGGCCCCTCCGACGACGGCCTCGGGCTAT
TCTATTCAGCTCTAGATTCCGTGCTGGCTTCCTGA

Upstream 100 bases:

>100_bases
AAATTGATGATACAGTTGATGACTCCGAGCTTGCCATGATCGCGGAGTCACTGTTGGCGAACACCGTGATCGAGGATTGG
ACGATAACTCGGGAGTCGCA

Downstream 100 bases:

>100_bases
GTAGAACAAATCAGCAGCATTGCGTAATTCGACAATGGAGAACGCTGAAACCGGGGTACAATAAACTGGCGTAGCGGAGC
GGCGGCTGTGTTTCCGACGG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRAGAIARLSPIMTEVVDAVQRG
MPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRVISTSTAWTSRFEPETDLLVSLKSGEGRYVASENVLDELDG
EGRVVFRYHDNINGSLRDIAGISSANGRVVGMMPHPEHAIEVLTGPSDDGLGLFYSALDSVLAS

Sequences:

>Translated_224_residues
MNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRAGAIARLSPIMTEVVDAVQRG
MPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRVISTSTAWTSRFEPETDLLVSLKSGEGRYVASENVLDELDG
EGRVVFRYHDNINGSLRDIAGISSANGRVVGMMPHPEHAIEVLTGPSDDGLGLFYSALDSVLAS
>Mature_224_residues
MNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRAGAIARLSPIMTEVVDAVQRG
MPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRVISTSTAWTSRFEPETDLLVSLKSGEGRYVASENVLDELDG
EGRVVFRYHDNINGSLRDIAGISSANGRVVGMMPHPEHAIEVLTGPSDDGLGLFYSALDSVLAS

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=230, Percent_Identity=28.2608695652174, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321498, Length=179, Percent_Identity=31.8435754189944, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582111, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582109, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137292, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_MYCLE (O05756)

Other databases:

- EMBL:   Z95151
- EMBL:   AL583924
- PIR:   F87186
- RefSeq:   NP_302453.1
- ProteinModelPortal:   O05756
- SMR:   O05756
- EnsemblBacteria:   EBMYCT00000029202
- GeneID:   908813
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2219
- NMPDR:   fig|272631.1.peg.1325
- Leproma:   ML2219
- GeneTree:   EBGT00050000016355
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   MLEP272631:ML2219-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23818; Mature: 23818

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 87-87 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRA
CCCEEEEEECCCCCCHHHHHHHHHHHCHHHHHEEECCCCCCCCCEEEECCCCCHHHHHHH
GAIARLSPIMTEVVDAVQRGMPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRV
CHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ISTSTAWTSRFEPETDLLVSLKSGEGRYVASENVLDELDGEGRVVFRYHDNINGSLRDIA
HHCCCHHCCCCCCCCCEEEEEECCCCCEEECCHHHHHCCCCCEEEEEEECCCCCCHHHHC
GISSANGRVVGMMPHPEHAIEVLTGPSDDGLGLFYSALDSVLAS
CCCCCCCEEEEECCCCHHHEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNARIGVITFPGTLDDVDAARAARHVGAEAVSLWHADADLKGVDAVVVPGGFSYGDYLRA
CCCEEEEEECCCCCCHHHHHHHHHHHCHHHHHEEECCCCCCCCCEEEECCCCCHHHHHHH
GAIARLSPIMTEVVDAVQRGMPVLGICNGFQVLCEAGLLPGALIRNVGLHFICRDVWLRV
CHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ISTSTAWTSRFEPETDLLVSLKSGEGRYVASENVLDELDGEGRVVFRYHDNINGSLRDIA
HHCCCHHCCCCCCCCCEEEEEECCCCCEEECCHHHHHCCCCCEEEEEEECCCCCCHHHHC
GISSANGRVVGMMPHPEHAIEVLTGPSDDGLGLFYSALDSVLAS
CCCCCCCEEEEECCCCHHHEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002