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The map label for this gene is purL

Identifier: 221230665

GI number: 221230665

Start: 2626878

End: 2629142

Strand: Reverse

Name: purL

Synonym: MLBr_02211

Alternate gene names: 221230665

Gene position: 2629142-2626878 (Counterclockwise)

Preceding gene: 221230666

Following gene: 221230664

Centisome position: 80.45

GC content: 61.19

Gene sequence:

>2265_bases
GTGATTGACACCGTTGAATATGCTGCTACCACCCCCGACCAGCCGCAACCGTTTGCTGAGCTGGGCCTCAGAGAGGACGA
GTACCAGCGAGTTCGCGAAATTCTAGGTCGGCGACCTACGGACACCGAGCTGGCGATGTATTCGGTGATGTGGAGTGAGC
ACTGTTCGTACAAGTCTTCCAAAGTTCACCTGCGTTACTTCGGTGAAACCACCACCGAGGAGATGCGTACCGGAATGCTG
GCCGGTATCGGTGAAAATGCTGGTGTTGTCGACATCGGTGACGGCTGGGCCGTCACTTTCAAGGTAGAATCGCACAACCA
CCCTTCTTATGTCGAGCCGTACCAGGGGGCCGCAACCGGCGTCGGCGGCATCGTACGTGACATCATGGCGATGGGCGCGC
GACCTGTCGCTGTGATGGACCAGCTTCGGTTCGGTGCTGCCGATGCGCTCGATACCCGCCGCGTGCTGGATGGCGTGGTC
CGCGGTATTGGCGGCTACGGCAACTCGCTGGGCTTGCCCAACATCGGCGGCGAGACTGTCTTCGACTCGTGCTACGACGG
CAATCCTCTGGTGAATGCGTTGTGTGTCGGGGTGTTACGCCAGGAGGATCTTCATTTGGCGTTTGCCTCGGGTGCGGGTA
ACAAGATCATTCTGTTCGGCGCGTGTACCGGGCTGGACGGTATCGGCGGGGTCTCGGTGTTGGCGTCGGACACCTTCGAT
GCTGAAGGAGCGCGGAAGAAACTCCCGTCGGTTCAGGTGGGTGACCCCTTTATGGAAAAGGTACTCATCGAGTGCTGTCT
GGAATTGTATGCTGGCGGGCTGGTGATCGGCATCCAAGACTTAGGAGGTGCAGGATTATCTTGTGCCACTTCGGAGTTGG
CATCAGCTGGGGACGTCGGAATGGCGATTCAACTCGACACCGTCCCGCGCCGCGCGAAGGATATGACGCCCGCCGAGGTG
TTCTGCAGCGAATCGCAGGAGCGCATGTGCGCGGTGGTTGCACCGGAGAACGTGGACGCCTTCTTGGCGGTCTGCCGCAA
ATGGGAGGTGCTGGCCACGGTGATTGGTGAGGTCACCGACGGCGACCGACTACGGATCACCTGGCACGGCGAGACAGTCG
TCGACGTGCCACCGCGCACCGTGGCCCATGAGGGACCGGTGTATCAGCGACCCGTCTCCCGCCCCGAATCACAGGAAGCC
TTGAACGCGGATTCATCGAAAGGATTGCCGCGACCGGTTAGCGGAGACGAGCTGCGTGCGACTTTGCTTGCACTGCTGGG
TAGTCCGCACTTGTGCAGCCGGGCTTTCATCACCGAGCAGTATGATCGGTATGTGCGCGGCAACACCGTCTTGGCCGAGC
ATGCCGACGCTGGCGTGCTGCGTATCGACGAGTCCACCGGCCGCGGTATTGCGTTGTCGACCGACGCGTCTGGACGCTAT
ACCCGGCTAGATCCCTATGCCGGTGCCCAACTGGCGCTGGCCGAGGCGTACCGCAACGTGGCTGTCACCGGTGCCACCCC
GGTCGCGGTGACCAACTGCCTCAACTTCGGTTCACCCGAAGATCCAGGAGTGATGTGGCAGTTCGCGCAGGCTGTGCGGG
GGCTGGCTGATGGTTGTGCGGCCCTGAAGATTCCTGTAACCGGCGGCAACGTCAGCTTTTACAATCAAACGGGGGCGGTG
GCGATCTTGCCCACGCCGGTGGTTGGGGTGCTCGGCGTCCTGGATAACGTGGCTAGACGTATCCACACGTCCTTAGGCAC
TGAACCTGGAGAGATTCTGATGTTGCTGGGTGACACCTATGACGAGTTCGACGGGTCCGTCTGGGCGCAAGTGATGGCTG
GCCACCTGGGTGGGCTGCCGCCCATGGTGGACTTGGCGCGTGAGAAGCTGCTGGCCGAGGTGCTGAGTTCGGCGTCGCGC
GACGAGCTGGTATCGGCAGCTCATGACCTGTCCGAAGGCGGCCTCGCCCAGGCTATCGTGGAATCGGCGTTGGCGGGTGA
AACTGGTTGCCGTATAGCGCTTCCCGAAGATGCTGATCCGTTCGTGATGCTCTTTTCCGAATCAGCAGGTCGGGTGCTGG
TAGCTGTGCCACGCCCCGAAGAGAGCCGGTTTCGGTCGATGTGCGAGGCGCGAGGTTTGCCAGCTATGCGTATCGGTGTG
GTCGATCAGGGTTCGGACTCGATAGAGGTTCGGGGTCAATTCACCGTGTCCCTGGCAGAACTGCGTATGACGTTCGAGGC
GGTGCTGCCGCGATTTTTCGGATAA

Upstream 100 bases:

>100_bases
AGTACCACCTGATTTTTGTTGCGGGTCTCCCACGCGAGCTAAGGCGACGGAGAATCTAGACTAGCTGCGTGACTTATCCG
GTTTGGGCAGGCTCACACGC

Downstream 100 bases:

>100_bases
GTTGGGCCGCGAAAAATTGAGGTTAGCGTGGTGGAACGGCTTCAAGTGCCCGTAGTTGCTTGTCGGAGCAAGCTACACTG
AATGTTACATTTATGTAAAG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MIDTVEYAATTPDQPQPFAELGLREDEYQRVREILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTTEEMRTGML
AGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADALDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDSCYDGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGACTGLDGIGGVSVLASDTFD
AEGARKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDVGMAIQLDTVPRRAKDMTPAEV
FCSESQERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVSRPESQEA
LNADSSKGLPRPVSGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADAGVLRIDESTGRGIALSTDASGRY
TRLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCAALKIPVTGGNVSFYNQTGAV
AILPTPVVGVLGVLDNVARRIHTSLGTEPGEILMLLGDTYDEFDGSVWAQVMAGHLGGLPPMVDLAREKLLAEVLSSASR
DELVSAAHDLSEGGLAQAIVESALAGETGCRIALPEDADPFVMLFSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGV
VDQGSDSIEVRGQFTVSLAELRMTFEAVLPRFFG

Sequences:

>Translated_754_residues
MIDTVEYAATTPDQPQPFAELGLREDEYQRVREILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTTEEMRTGML
AGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADALDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDSCYDGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGACTGLDGIGGVSVLASDTFD
AEGARKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDVGMAIQLDTVPRRAKDMTPAEV
FCSESQERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVSRPESQEA
LNADSSKGLPRPVSGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADAGVLRIDESTGRGIALSTDASGRY
TRLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCAALKIPVTGGNVSFYNQTGAV
AILPTPVVGVLGVLDNVARRIHTSLGTEPGEILMLLGDTYDEFDGSVWAQVMAGHLGGLPPMVDLAREKLLAEVLSSASR
DELVSAAHDLSEGGLAQAIVESALAGETGCRIALPEDADPFVMLFSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGV
VDQGSDSIEVRGQFTVSLAELRMTFEAVLPRFFG
>Mature_754_residues
MIDTVEYAATTPDQPQPFAELGLREDEYQRVREILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTTEEMRTGML
AGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADALDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDSCYDGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGACTGLDGIGGVSVLASDTFD
AEGARKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDVGMAIQLDTVPRRAKDMTPAEV
FCSESQERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVSRPESQEA
LNADSSKGLPRPVSGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADAGVLRIDESTGRGIALSTDASGRY
TRLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCAALKIPVTGGNVSFYNQTGAV
AILPTPVVGVLGVLDNVARRIHTSLGTEPGEILMLLGDTYDEFDGSVWAQVMAGHLGGLPPMVDLAREKLLAEVLSSASR
DELVSAAHDLSEGGLAQAIVESALAGETGCRIALPEDADPFVMLFSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGV
VDQGSDSIEVRGQFTVSLAELRMTFEAVLPRFFG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=707, Percent_Identity=23.6209335219236, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI48994899, Length=773, Percent_Identity=27.2962483829237, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17553022, Length=748, Percent_Identity=23.6631016042781, Blast_Score=119, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321498, Length=810, Percent_Identity=25.3086419753086, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_MYCLB (B8ZSV5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002504081.1
- ProteinModelPortal:   B8ZSV5
- SMR:   B8ZSV5
- EnsemblBacteria:   EBMYCT00000086255
- GeneID:   7324832
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00070000032295
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80132; Mature: 80132

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTVEYAATTPDQPQPFAELGLREDEYQRVREILGRRPTDTELAMYSVMWSEHCSYKSS
CCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
KVHLRYFGETTTEEMRTGMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATG
EEEEEECCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCCH
VGGIVRDIMAMGARPVAVMDQLRFGAADALDTRRVLDGVVRGIGGYGNSLGLPNIGGETV
HHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
FDSCYDGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGACTGLDGIGGVSVLASDTFD
HHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCCCEEEEECCCCC
AEGARKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDVG
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
MAIQLDTVPRRAKDMTPAEVFCSESQERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTD
EEEEECCCCCHHCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
GDRLRITWHGETVVDVPPRTVAHEGPVYQRPVSRPESQEALNADSSKGLPRPVSGDELRA
CCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHH
TLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADAGVLRIDESTGRGIALSTDASGRY
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCE
TRLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCA
EEECCCCCHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCE
ALKIPVTGGNVSFYNQTGAVAILPTPVVGVLGVLDNVARRIHTSLGTEPGEILMLLGDTY
EEEEEEECCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCH
DEFDGSVWAQVMAGHLGGLPPMVDLAREKLLAEVLSSASRDELVSAAHDLSEGGLAQAIV
HHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
ESALAGETGCRIALPEDADPFVMLFSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGV
HHHHCCCCCCEEECCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEE
VDQGSDSIEVRGQFTVSLAELRMTFEAVLPRFFG
EECCCCCEEEEEEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDTVEYAATTPDQPQPFAELGLREDEYQRVREILGRRPTDTELAMYSVMWSEHCSYKSS
CCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
KVHLRYFGETTTEEMRTGMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATG
EEEEEECCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCCH
VGGIVRDIMAMGARPVAVMDQLRFGAADALDTRRVLDGVVRGIGGYGNSLGLPNIGGETV
HHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
FDSCYDGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGACTGLDGIGGVSVLASDTFD
HHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCCCEEEEECCCCC
AEGARKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDVG
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
MAIQLDTVPRRAKDMTPAEVFCSESQERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTD
EEEEECCCCCHHCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
GDRLRITWHGETVVDVPPRTVAHEGPVYQRPVSRPESQEALNADSSKGLPRPVSGDELRA
CCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHH
TLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADAGVLRIDESTGRGIALSTDASGRY
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCE
TRLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCA
EEECCCCCHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCE
ALKIPVTGGNVSFYNQTGAVAILPTPVVGVLGVLDNVARRIHTSLGTEPGEILMLLGDTY
EEEEEEECCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCH
DEFDGSVWAQVMAGHLGGLPPMVDLAREKLLAEVLSSASRDELVSAAHDLSEGGLAQAIV
HHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
ESALAGETGCRIALPEDADPFVMLFSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGV
HHHHCCCCCCEEECCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEE
VDQGSDSIEVRGQFTVSLAELRMTFEAVLPRFFG
EECCCCCEEEEEEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA