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The map label for this gene is 221230628

Identifier: 221230628

GI number: 221230628

Start: 2543851

End: 2545590

Strand: Direct

Name: 221230628

Synonym: MLBr_02143

Alternate gene names: NA

Gene position: 2543851-2545590 (Clockwise)

Preceding gene: 221230626

Following gene: 221230629

Centisome position: 77.84

GC content: 60.75

Gene sequence:

>1740_bases
GTGTCTGGACGGCGGCGTAATCATCCGGGCCGTTTGGCCTCTATACCAGGCCTCCGGACCCGCACCGGCTCGCGTAACCA
GCATCCAGGCATTGCGAACTACCCGGCCGACAGCTCTGACTTTCGGCCAGCCCAGCAACGGAGAGCGCTGGAACAGCGCG
AACAACAAGCCGGGCAGTTGGACCCAGCGCGCCGCTCGCCGTCGATGCCCAGCGCCAACCGCTATCTCCCGCCCCTGGGC
CAGCAGCAGTCAGAACCCCAACACAACAGTGCGCCACCATGCGGTCCGTACCCTGGTGAACGAATTAAGGTCACTCGCGC
TGCCGCACAGCGAAGCCGTGAAATGGGCTACCGAATGTACTGGATGGTTCAGCGTGCCGCCACCGCTGACGGCGCTGACA
AATCCGGGCTAACTGCATTGACGTGGCCGGTGGTCACGAACTTTGCGGTAGACTCCGCAATGGCCGTTGCACTGGCCAAC
ACTTTGTTCTTCGCCGCGGCCAGCGGGGAGAGCAAATCCAAAGTCGCGCTGTACCTGCTGATCACCATCGCTCCGTTCGC
GGTGATCGCGCCGCTCATCGGTCCGGCGCTAGACCGGCTGCAGCACGGCCGCCGCGTGGCGCTGGCAACCTCATTCGTGC
TACGCACCGGATTGGCAACACTACTGATCATGAACTACGACGGCGCCACCGGCAGCTACCCGTCCATGGTGCTCTACCCG
TGCGCGCTGGCCATGATGGTGTTGTCGAAATCGTTCAGCGTGCTGCGCAGCGCTGTCACACCAAGAGTGATGCCGCCCAG
CATTGATCTGGTACGCGTCAATTCTCGGCTGACCGTGTTCGGTCTGCTCGGCGGCACCATCGCCGGTGGCGCCATCGCGG
CCGGTGTCGAGTTCGTCTGCGCCCACCTGTTCAAGCTGCCTGGCGCATTGTTCGTCGTCGCCGCGATCACGATCTCCGGC
GCCTTGCTGTCAATGCGGATTCCGCGCTGGGTCGAGGTAACCGCGGGTGAAATTCCAGCCACTTTGAGCTATCGCTTGCA
TCGCAAACCATTGCGACAGAGCTGGCCTGAGGAAGTCAAGAAGGTCAGCGGCAGACTTCGACAACCGTTGGGCCGCAATA
TCATTACCTCGTTGTGGGGCAATTGCACCATCAAAGTGATGGTCGGCTTCCTATTCTTATATCCTGCGTTTGTCGCCAAA
GAGCATCAAGCCAATGGCTGGGTCCAGCTGGGGATGCTGGGCTTGATCGGCACTGCTGCCGCGATCGGCAACTTCGCTGG
CAATTTCACCAGCGCACGCCTGCAGCTGGGCAGGCCGGCCGTGCTGGTGGTGCGCTGCACAATCGCGGTCACTGTGTTAG
CCTTAGCGGCGTCAGTGGCTGGCAATCTACTGATGACTACTATCGCTACCCTGATCACATCGGGATCTAGTGCAATTGCG
AAGGCTTCGTTGGACGCCTCGTTGCAAAATGATTTGCCTGAGGAGTCACGAGCATCGGGATTCGGCCGTTCAGAATCAAC
GCTGCAACTAGCATGGGTGCTAGGCGGAGCACTAGGCGTGATGGTGTACACCGATTTGTGGGTCGGATTCACCGCGGTCA
GTGCCTTGCTGATCCTAGGTCTAGCGCAAACCGTCGTGAGCTTTCGCGGTGATTCGTTAATTCCAGGCCTCGGAGGTAAT
CGTCCGGTGATGATTGAGCAGGAGAGCATGCGCCGCGCCGCGGCGGTGAGTCCTCAATGA

Upstream 100 bases:

>100_bases
TCTTTGCAACCCATAATCCAATTCTGCCGGAAGACACAGTTTGCAAGCGACACCCGGCCTCCTGCACACGCATGAAGTCG
ACATAGGACAGAATTGATTC

Downstream 100 bases:

>100_bases
GACCCTGGTGCAACGCCGGGTAACCGTGCTGCTCCCGGCCGTGGTGATGCTGCTAGCCGCCGCGGCCGGGTTCGGCGTAT
GGCTGCTGGTGCGCGAGCCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRALEQREQQAGQLDPARRSPSMPSANRYLPPLG
QQQSEPQHNSAPPCGPYPGERIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFAVDSAMAVALAN
TLFFAAASGESKSKVALYLLITIAPFAVIAPLIGPALDRLQHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYP
CALAMMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVCAHLFKLPGALFVVAAITISG
ALLSMRIPRWVEVTAGEIPATLSYRLHRKPLRQSWPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAK
EHQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVLVVRCTIAVTVLALAASVAGNLLMTTIATLITSGSSAIA
KASLDASLQNDLPEESRASGFGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILGLAQTVVSFRGDSLIPGLGGN
RPVMIEQESMRRAAAVSPQ

Sequences:

>Translated_579_residues
MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRALEQREQQAGQLDPARRSPSMPSANRYLPPLG
QQQSEPQHNSAPPCGPYPGERIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFAVDSAMAVALAN
TLFFAAASGESKSKVALYLLITIAPFAVIAPLIGPALDRLQHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYP
CALAMMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVCAHLFKLPGALFVVAAITISG
ALLSMRIPRWVEVTAGEIPATLSYRLHRKPLRQSWPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAK
EHQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVLVVRCTIAVTVLALAASVAGNLLMTTIATLITSGSSAIA
KASLDASLQNDLPEESRASGFGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILGLAQTVVSFRGDSLIPGLGGN
RPVMIEQESMRRAAAVSPQ
>Mature_578_residues
SGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRALEQREQQAGQLDPARRSPSMPSANRYLPPLGQ
QQSEPQHNSAPPCGPYPGERIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFAVDSAMAVALANT
LFFAAASGESKSKVALYLLITIAPFAVIAPLIGPALDRLQHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYPC
ALAMMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVCAHLFKLPGALFVVAAITISGA
LLSMRIPRWVEVTAGEIPATLSYRLHRKPLRQSWPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAKE
HQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVLVVRCTIAVTVLALAASVAGNLLMTTIATLITSGSSAIAK
ASLDASLQNDLPEESRASGFGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILGLAQTVVSFRGDSLIPGLGGNR
PVMIEQESMRRAAAVSPQ

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.tuberculosis Rv0876c

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2143_MYCLE (O33057)

Other databases:

- EMBL:   Z99494
- EMBL:   AL583924
- PIR:   T45344
- RefSeq:   NP_302414.1
- ProteinModelPortal:   O33057
- EnsemblBacteria:   EBMYCT00000027978
- GeneID:   908890
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2143
- NMPDR:   fig|272631.1.peg.1286
- Leproma:   ML2143
- GeneTree:   EBGT00050000014799
- HOGENOM:   HBG565082
- OMA:   VLQLSWV
- ProtClustDB:   CLSK871868
- BioCyc:   MLEP272631:ML2143-MONOMER
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 61708; Mature: 61576

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x21afe634)-; HASH(0x22ac795c)-; HASH(0x21bf1098)-; HASH(0x22c684cc)-; HASH(0x22ac68dc)-; HASH(0x22cfafec)-; HASH(0x23255858)-; HASH(0x230552f0)-; HASH(0x21c8f25c)-; HASH(0x22be9d4c)-; HASH(0x225d9cac)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRALEQREQQAGQL
CCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
DPARRSPSMPSANRYLPPLGQQQSEPQHNSAPPCGPYPGERIKVTRAAAQRSREMGYRMY
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHH
WMVQRAATADGADKSGLTALTWPVVTNFAVDSAMAVALANTLFFAAASGESKSKVALYLL
HHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEHHH
ITIAPFAVIAPLIGPALDRLQHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYP
HHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHH
CALAMMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHH
AHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEIPATLSYRLHRKPLRQSWPEEVK
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCHHHHCCHHHHH
KVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAKEHQANGWVQLGMLGLIGTAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
AIGNFAGNFTSARLQLGRPAVLVVRCTIAVTVLALAASVAGNLLMTTIATLITSGSSAIA
HHHHHCCCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KASLDASLQNDLPEESRASGFGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILG
HHHHCCHHHHCCCCHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQTVVSFRGDSLIPGLGGNRPVMIEQESMRRAAAVSPQ
HHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHCCCCH
>Mature Secondary Structure 
SGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRALEQREQQAGQL
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
DPARRSPSMPSANRYLPPLGQQQSEPQHNSAPPCGPYPGERIKVTRAAAQRSREMGYRMY
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHH
WMVQRAATADGADKSGLTALTWPVVTNFAVDSAMAVALANTLFFAAASGESKSKVALYLL
HHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEHHH
ITIAPFAVIAPLIGPALDRLQHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYP
HHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHH
CALAMMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHH
AHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEIPATLSYRLHRKPLRQSWPEEVK
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCHHHHCCHHHHH
KVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAKEHQANGWVQLGMLGLIGTAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
AIGNFAGNFTSARLQLGRPAVLVVRCTIAVTVLALAASVAGNLLMTTIATLITSGSSAIA
HHHHHCCCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KASLDASLQNDLPEESRASGFGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILG
HHHHCCHHHHCCCCHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQTVVSFRGDSLIPGLGGNRPVMIEQESMRRAAAVSPQ
HHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002