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The map label for this gene is echA6

Identifier: 221230614

GI number: 221230614

Start: 2518695

End: 2519438

Strand: Reverse

Name: echA6

Synonym: MLBr_02118

Alternate gene names: 221230614

Gene position: 2519438-2518695 (Counterclockwise)

Preceding gene: 221230615

Following gene: 221230613

Centisome position: 77.09

GC content: 59.95

Gene sequence:

>744_bases
ATGATAGGTATTACTCAGGCCGAAGGCGTTATGACTATCGAGCTGCAGCGTCCCGAGCGCCGCAATGCCCTGAATTCGCA
ACTTATCGAGAAGCTGCGGGAGGCTGTGCAGAAAGCTAGTAGCGCCGACAGTGAGGTGTCTACCCGTGTGATTGTGTTGA
CTGGCCAGGGCACGGTGTTCTGTGCCGGCGCGGATCTGAGCGGAGATGCGTTTGCCGCTGACTACCCTGACCGGCTGATC
GAGTTACACAGGGTCATGGATGCTGTTCCGATGCCGGTAATTGGCGCTATTAACGGGCCCGCCATCGGTGCTGGTCTACA
GTTGGCCATGCAATGTGATCTGCGGGTTGTTGCACCGGATGCGTATTTTCAGTTTCCTACCTCGAAATATGGTTTGGCCC
TTGACAACTGGAGTATTCGCCGACTGTCTTCGTTGGTTGGTCACGGCCGGGCCCGCGCGATGCTGCTGACGGCGGAGAAG
TTGACCGCCGACATCGCGCTGCAGACCGGGATGGCCAATCGCATCGGTGCACTGGCCGACGCCCAGGCCTGGGCCGCCGA
GGTCACCGGCCTAGCACCACTGGCGATCCAGCACGCCAAGCGGGTACTCAACGACGACGGCTCTATCGAAGAGGCGTGGC
CGGAGCACAAGAAGCTCTTTGACAAGGCCTGGACCAGCCAGGATGTCATCGAAGCGCAGGTCGCCCGGGTGGAGAAACGG
CCACCTAAGTTTCAGGGGGCATGA

Upstream 100 bases:

>100_bases
TCGCGGTCTCAGCTAACGAATGAACCAACGTCTAGCACTGCCTCGCGGAGTTGATCGGTCGTAGTACGACTCATCCGACG
AGGCTCTATAGGCTGGCTTA

Downstream 100 bases:

>100_bases
CATTCATGCATGCTGCGCAGAGCGCTGTGATTGGCTGCTGGTATGTCCGCCCTGATGGTTTGCTGTTGTAAGCACTGCAC
GGCGTGCAGGCAGTCTTTCA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQKASSADSEVSTRVIVLTGQGTVFCAGADLSGDAFAADYPDRLI
ELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPDAYFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEK
LTADIALQTGMANRIGALADAQAWAAEVTGLAPLAIQHAKRVLNDDGSIEEAWPEHKKLFDKAWTSQDVIEAQVARVEKR
PPKFQGA

Sequences:

>Translated_247_residues
MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQKASSADSEVSTRVIVLTGQGTVFCAGADLSGDAFAADYPDRLI
ELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPDAYFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEK
LTADIALQTGMANRIGALADAQAWAAEVTGLAPLAIQHAKRVLNDDGSIEEAWPEHKKLFDKAWTSQDVIEAQVARVEKR
PPKFQGA
>Mature_247_residues
MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQKASSADSEVSTRVIVLTGQGTVFCAGADLSGDAFAADYPDRLI
ELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPDAYFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEK
LTADIALQTGMANRIGALADAQAWAAEVTGLAPLAIQHAKRVLNDDGSIEEAWPEHKKLFDKAWTSQDVIEAQVARVEKR
PPKFQGA

Specific function: Could possibly oxidize fatty acids using specific components

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family

Homologues:

Organism=Homo sapiens, GI70995211, Length=258, Percent_Identity=31.0077519379845, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI194097323, Length=242, Percent_Identity=30.1652892561983, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI25453481, Length=259, Percent_Identity=24.7104247104247, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI51538573, Length=259, Percent_Identity=24.7104247104247, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4757968, Length=259, Percent_Identity=25.4826254826255, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI49355787, Length=259, Percent_Identity=25.4826254826255, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI4757966, Length=247, Percent_Identity=24.6963562753036, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI51538581, Length=247, Percent_Identity=24.6963562753036, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI221136756, Length=261, Percent_Identity=24.5210727969349, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI221136753, Length=261, Percent_Identity=24.5210727969349, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI221307494, Length=261, Percent_Identity=24.5210727969349, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI45643119, Length=216, Percent_Identity=26.3888888888889, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI260275230, Length=216, Percent_Identity=26.3888888888889, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI260274832, Length=216, Percent_Identity=26.3888888888889, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI116235487, Length=185, Percent_Identity=28.6486486486486, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI31542718, Length=183, Percent_Identity=30.0546448087432, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=26.8774703557312, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=32.1428571428571, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788597, Length=253, Percent_Identity=27.6679841897233, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI221142681, Length=259, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI87082183, Length=259, Percent_Identity=25.8687258687259, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787660, Length=254, Percent_Identity=30.7086614173228, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788682, Length=178, Percent_Identity=29.2134831460674, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=28.2868525896414, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=251, Percent_Identity=30.2788844621514, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=266, Percent_Identity=26.3157894736842, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560910, Length=195, Percent_Identity=32.3076923076923, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=265, Percent_Identity=28.6792452830189, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=225, Percent_Identity=25.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=249, Percent_Identity=24.4979919678715, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=206, Percent_Identity=26.6990291262136, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129971, Length=252, Percent_Identity=29.3650793650794, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653477, Length=252, Percent_Identity=29.3650793650794, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=24.3137254901961, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920382, Length=222, Percent_Identity=30.1801801801802, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357171, Length=242, Percent_Identity=27.6859504132231, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650670, Length=185, Percent_Identity=28.6486486486486, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24654903, Length=217, Percent_Identity=24.8847926267281, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922422, Length=259, Percent_Identity=23.5521235521236, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECHA6_MYCLE (Q50130)

Other databases:

- EMBL:   U15184
- EMBL:   AL583924
- PIR:   A87174
- RefSeq:   NP_302400.1
- ProteinModelPortal:   Q50130
- SMR:   Q50130
- EnsemblBacteria:   EBMYCT00000028073
- GeneID:   908912
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2118
- NMPDR:   fig|272631.1.peg.1272
- Leproma:   ML2118
- GeneTree:   EBGT00050000015506
- HOGENOM:   HBG748731
- OMA:   WPEHKEL
- ProtClustDB:   PRK07854
- BioCyc:   MLEP272631:ML2118-MONOMER
- BRENDA:   4.2.1.17
- InterPro:   IPR001753
- InterPro:   IPR018376

Pfam domain/function: PF00378 ECH

EC number: =4.2.1.17

Molecular weight: Translated: 26654; Mature: 26654

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQKASSADSEVSTRVIVLTGQGTVF
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEE
CAGADLSGDAFAADYPDRLIELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPD
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHEEEEECCEEEECCC
AYFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEKLTADIALQTGMANRIGALAD
CEEECCCCCCCEEECCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHH
AQAWAAEVTGLAPLAIQHAKRVLNDDGSIEEAWPEHKKLFDKAWTSQDVIEAQVARVEKR
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PPKFQGA
CCCCCCC
>Mature Secondary Structure
MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQKASSADSEVSTRVIVLTGQGTVF
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEE
CAGADLSGDAFAADYPDRLIELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPD
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHEEEEECCEEEECCC
AYFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEKLTADIALQTGMANRIGALAD
CEEECCCCCCCEEECCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHH
AQAWAAEVTGLAPLAIQHAKRVLNDDGSIEEAWPEHKKLFDKAWTSQDVIEAQVARVEKR
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PPKFQGA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002