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The map label for this gene is yddA [C]

Identifier: 221230604

GI number: 221230604

Start: 2476878

End: 2478794

Strand: Direct

Name: yddA [C]

Synonym: MLBr_02084

Alternate gene names: 221230604

Gene position: 2476878-2478794 (Clockwise)

Preceding gene: 221230594

Following gene: 221230606

Centisome position: 75.79

GC content: 56.6

Gene sequence:

>1917_bases
GTGGAGTTAAGACCATTCTATCCATCTGTCAACTGGGGCTACGCGCTGCCAGACTCGTTGTGGTGGATCGCCAAGGCATG
GGCGATCAGTGCCGCTTGCGTCGTTGTCTTGGTAATGCTCAGTTTTATCACCCGCTGGGGTCGCCAATACTGGCGGATTA
CCCGCGGCTATTTCATCGGACCGCAGTCGGTCGGGGTGTGGCTGATGCTAGCTGTGCTGCTGTTCTCGGTCGTCATCAGC
GTGCGGTTGAACGTTTTGTTCAGCTACCAAAGCAAAGACTTGTATAACGCGCTGCAAGCAGCCTTCGAAGGCGCCGGCGC
ACAGAACGACCTGGTTAAACAGTCAGGTATGCACGGCTTTTGGATGTCGCTCGGAATCTTCTCCATTTTGGCAGTCATAT
TCATTGCCCGCGTGATGGCCGACATTTATCTGACCCAGCGGTTCATCATCGCCTGGCGAATGTGGCTTACCAACCACCTC
ACAACTGACTGGCTGGACCAGCGCGCCTATTACCGGGAACAATTCATCGACAATACGATCGACAACCCCGACCAACGTAT
CCAGCAAGACATCGATATCTTCACCGCCGGCGCCGGCGGCACCCCCAACGGTCCCTCCAACGGAACGGGCAGCACACTGT
TGTTTGGGGCTGTCGAATCGGTGATATCGGTGATTTCGTTCACCGCGATCTTGTGGAACCTTTCCGGTCGGCTCGCCGTG
TTTGAGTTCGAAATACCGCGCGCCATGTTCTGGATCGTCATTGTCTACGTGCTGTTAGCAACGATCATAACGTTCTGGAT
CGGCCGCCCATTAATCGGGCTGAACTTTGCCAACGAAAAACTCAACGCCGCCTTCCGCTATGCGTTAGTGCGGTTGCGCG
ACGCTGCCGAGGCGGTTGCATTTTATCGGGGTGAGGAGGCTGAACGGAAGCAATTGGAGCAGCGCTTCACACCGATTATT
GACAATTACCGCAGGTACGTCAGCCGCACTATAAGATTCCTAGGTTGGAACGCCTCGGTAAGCCAGACCATTGTTCCGCT
ACCGTGGATTCTTCAGGCACCGCGGCTGTTCGCCGGGAAAATTAACTTGGGGGACGTCGGCCAAACCGCGACCGCATTCG
GCAATATTCACGACTCGTTATCGTTCTTTCGCAACAATTATGCCGCATTTGCGGCTTTCCGGGCCGCAATCATCCGGTTG
CATGGACTCGTCGTTGCAAATGCTCGCAGCCGGGAGTTGCCCCACGTAACAGCTAAGTCGACGAACGATGGTACAGTTCA
TGTGGTCGCTGTCGAGGTGCGAACGTCGGCAGGCGAGCAGCTGATTGACCCGCTCGACCTGCAACTTAATTGCGGTAGTT
CACTGGTCATCACTGGGCGCTCCGGGGTAGGCAAGACCACAATGCTGCGCAGCCTGGCCGAATTGTGGCCATACGCTTCC
GGGACCCTAAGCCGCCCCGACGGCAAGAACGAAACGATGTTCTTATCGCAGTTGCCCTATGTACCACTGGGCAACCTACG
CGGCGTGGTGTGTTACCCAAATGCGCCCGCCGACATCCCTGAAGACACTGTGCGGGACACCCTAACGAAGGTAGCCCTCA
ACCCGCTGTGTGACCGGCTAGACGAAGAACGGGACTGGGCCAAGATACTATCCCCAGGCGAGCAACAACGCATTGCCTTT
GCCCGTATCCTGCTCACCAAACCAAAGGCAATATTCCTCGACGAAAGTACGTCCGCGCTTGACGAAGGGCTGGAATTCGC
ACTCTACCAAATGCTGCGAAGCGAACTGCCAGACTGCATCATCGTCAGCGTTAGCCATCGGCGCGCAGTCGAGCTGCTCC
ACGCACAACAGCTGGAACTGCTTGGCGGCGGCCAGTGGCGACTGGGCCCAGTGGAAAAGGAGCCGCTGCATGTCTAG

Upstream 100 bases:

>100_bases
TGCTCATATCAGCAGCCTATCCGCGACTTTCGGGTACCTTCGCCGAGAGATTTCTGTATTGAGGTGCTTTCAGCGCCTCA
ATCGCGAGGAGACATCAAAC

Downstream 100 bases:

>100_bases
CTAGCGCGGTGCTACCGCACGCTAACAGGTAGCACCCTTGCAGGGTTAACGAGTACAGGTTCGCATGCCCGAGCTCAAAT
TCACGGGACGAAGTGTCCAT

Product: putative multidrug resistance pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MELRPFYPSVNWGYALPDSLWWIAKAWAISAACVVVLVMLSFITRWGRQYWRITRGYFIGPQSVGVWLMLAVLLFSVVIS
VRLNVLFSYQSKDLYNALQAAFEGAGAQNDLVKQSGMHGFWMSLGIFSILAVIFIARVMADIYLTQRFIIAWRMWLTNHL
TTDWLDQRAYYREQFIDNTIDNPDQRIQQDIDIFTAGAGGTPNGPSNGTGSTLLFGAVESVISVISFTAILWNLSGRLAV
FEFEIPRAMFWIVIVYVLLATIITFWIGRPLIGLNFANEKLNAAFRYALVRLRDAAEAVAFYRGEEAERKQLEQRFTPII
DNYRRYVSRTIRFLGWNASVSQTIVPLPWILQAPRLFAGKINLGDVGQTATAFGNIHDSLSFFRNNYAAFAAFRAAIIRL
HGLVVANARSRELPHVTAKSTNDGTVHVVAVEVRTSAGEQLIDPLDLQLNCGSSLVITGRSGVGKTTMLRSLAELWPYAS
GTLSRPDGKNETMFLSQLPYVPLGNLRGVVCYPNAPADIPEDTVRDTLTKVALNPLCDRLDEERDWAKILSPGEQQRIAF
ARILLTKPKAIFLDESTSALDEGLEFALYQMLRSELPDCIIVSVSHRRAVELLHAQQLELLGGGQWRLGPVEKEPLHV

Sequences:

>Translated_638_residues
MELRPFYPSVNWGYALPDSLWWIAKAWAISAACVVVLVMLSFITRWGRQYWRITRGYFIGPQSVGVWLMLAVLLFSVVIS
VRLNVLFSYQSKDLYNALQAAFEGAGAQNDLVKQSGMHGFWMSLGIFSILAVIFIARVMADIYLTQRFIIAWRMWLTNHL
TTDWLDQRAYYREQFIDNTIDNPDQRIQQDIDIFTAGAGGTPNGPSNGTGSTLLFGAVESVISVISFTAILWNLSGRLAV
FEFEIPRAMFWIVIVYVLLATIITFWIGRPLIGLNFANEKLNAAFRYALVRLRDAAEAVAFYRGEEAERKQLEQRFTPII
DNYRRYVSRTIRFLGWNASVSQTIVPLPWILQAPRLFAGKINLGDVGQTATAFGNIHDSLSFFRNNYAAFAAFRAAIIRL
HGLVVANARSRELPHVTAKSTNDGTVHVVAVEVRTSAGEQLIDPLDLQLNCGSSLVITGRSGVGKTTMLRSLAELWPYAS
GTLSRPDGKNETMFLSQLPYVPLGNLRGVVCYPNAPADIPEDTVRDTLTKVALNPLCDRLDEERDWAKILSPGEQQRIAF
ARILLTKPKAIFLDESTSALDEGLEFALYQMLRSELPDCIIVSVSHRRAVELLHAQQLELLGGGQWRLGPVEKEPLHV
>Mature_638_residues
MELRPFYPSVNWGYALPDSLWWIAKAWAISAACVVVLVMLSFITRWGRQYWRITRGYFIGPQSVGVWLMLAVLLFSVVIS
VRLNVLFSYQSKDLYNALQAAFEGAGAQNDLVKQSGMHGFWMSLGIFSILAVIFIARVMADIYLTQRFIIAWRMWLTNHL
TTDWLDQRAYYREQFIDNTIDNPDQRIQQDIDIFTAGAGGTPNGPSNGTGSTLLFGAVESVISVISFTAILWNLSGRLAV
FEFEIPRAMFWIVIVYVLLATIITFWIGRPLIGLNFANEKLNAAFRYALVRLRDAAEAVAFYRGEEAERKQLEQRFTPII
DNYRRYVSRTIRFLGWNASVSQTIVPLPWILQAPRLFAGKINLGDVGQTATAFGNIHDSLSFFRNNYAAFAAFRAAIIRL
HGLVVANARSRELPHVTAKSTNDGTVHVVAVEVRTSAGEQLIDPLDLQLNCGSSLVITGRSGVGKTTMLRSLAELWPYAS
GTLSRPDGKNETMFLSQLPYVPLGNLRGVVCYPNAPADIPEDTVRDTLTKVALNPLCDRLDEERDWAKILSPGEQQRIAF
ARILLTKPKAIFLDESTSALDEGLEFALYQMLRSELPDCIIVSVSHRRAVELLHAQQLELLGGGQWRLGPVEKEPLHV

Specific function: Unknown

COG id: COG4178

COG function: function code R; ABC-type uncharacterized transport system, permease and ATPase components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI4826958, Length=561, Percent_Identity=27.0944741532977, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI4506341, Length=581, Percent_Identity=25.1290877796902, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI9945308, Length=544, Percent_Identity=25.5514705882353, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI7262393, Length=553, Percent_Identity=24.4122965641953, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI9955963, Length=288, Percent_Identity=25, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1787772, Length=536, Percent_Identity=29.4776119402985, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI1787112, Length=258, Percent_Identity=25.1937984496124, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786575, Length=379, Percent_Identity=21.3720316622691, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532409, Length=531, Percent_Identity=24.8587570621469, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17564250, Length=515, Percent_Identity=26.7961165048544, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI72000520, Length=492, Percent_Identity=27.0325203252033, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI72000518, Length=545, Percent_Identity=24.954128440367, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17532411, Length=221, Percent_Identity=33.0316742081448, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17558960, Length=205, Percent_Identity=40, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17542146, Length=215, Percent_Identity=29.3023255813954, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17558664, Length=182, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325110, Length=256, Percent_Identity=31.640625, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24643394, Length=534, Percent_Identity=25.2808988764045, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24638558, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638550, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638552, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638554, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638546, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638556, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638548, Length=549, Percent_Identity=22.5865209471767, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI23397593, Length=202, Percent_Identity=26.2376237623762, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010509
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF06472 ABC_membrane_2; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 71557; Mature: 71557

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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EEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]