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The map label for this gene is adhA [H]

Identifier: 221230584

GI number: 221230584

Start: 2441022

End: 2442029

Strand: Reverse

Name: adhA [H]

Synonym: MLBr_02053

Alternate gene names: 221230584

Gene position: 2442029-2441022 (Counterclockwise)

Preceding gene: 221230585

Following gene: 221230580

Centisome position: 74.72

GC content: 63.19

Gene sequence:

>1008_bases
ATGCATGCGTGGCGGGTGCGTCGGCCCGGCCCGATACAAACCAGCCCGCTCGAGTGGGTTACCACCGAGGTGCCGTGTCC
CGAACCGTCTGAACTTCTGGTTGCTGTACGTGCGTGTGGGGTATGTCGTACCGATCTGCATGTCGCTGAGGGTGACCTCC
CCGTGCACCGCGAGCACGTGACTCCCGGCCACGAGGTAGTGGGGGAGGTCTTGGGGGTGGGATCGGACGTGGATGCGGCC
GCTGGGTTCGATGTGGGGGACCGGGTAGGCATAGCCTGGTTGCGCTACACCTGCGGCGTGTGCAACTATTGCCGTAGCGG
TACCGAGAACCTGTGTGTGCAGTCCCGCTATACCGGCTGGGATGTCGACGGTGGATACGCCGAATTTACTACTGTTCCTG
CGGCTTTCGCACATCACCTACCGAGCGGCTATAGTGACTGCGAGCTTGCGCCGTTGTTGTGTGCCGGCATCATCGGGTAC
CGATCGTTGCTGCGATCCGAGTTACCGCCGGGCGGCCGGTTAGGTATCTACGGCTTTGGGGGCAGCGCTCACATCGCAGC
ACAGGTTGCCTTGGTGCAAGGCGCAGAGGTGCATGTTATGACCCGCGGAGCCCGGGCGCAGGAGCTGGCGTTAGAACTCG
GCGCTGCGTCGGCTCAAGGCGTCGCTGATCTGCCGCCGGTACCGCTGGATGCCGCGATCGTGTTCGCGCCGGTTGGTGAT
CTAGTGCTGCCCGCGTGCGAGGCGCTGAACCGCGGCGGCACCCTGGCGATCGCAGGGATTCATCTTTCCGATATTCCGCA
GCTGAACTACCAGCGACACTTGTTTCAAGAGCGTCAGATTCGGTCGGTGACATCGAACACTAGGGCTGATGCCCGTGCGT
TCCTCGACTTCGCGGCCCAGCATCACATCGCGGTCACCACGCCGGAATATCCGCTTGAGCAAGCCGATCAGGCGCTGACC
GATCTCAGCGTCGGCCGCATCTCAGGCGCTGCTGTGCTGCTGGCGTAA

Upstream 100 bases:

>100_bases
TCGGCAGGGTACGAAAGACCTAACTTGGCTGTGATGACTTCAACTGGTCGCCGGCGGATCACGACATGATGGCGTGATGG
CCTCGAAAGTGACCAGGATG

Downstream 100 bases:

>100_bases
CCGAGTCAAGTCGATAGATGCCAGACCAACGCAGCTACTAGGTCACCCAATTCGTTCAGTGACCCATATAGCGCTATCGG
CTCAAGAGGCTATCGCTACG

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLVAVRACGVCRTDLHVAEGDLPVHREHVTPGHEVVGEVLGVGSDVDAA
AGFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSRYTGWDVDGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGY
RSLLRSELPPGGRLGIYGFGGSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVADLPPVPLDAAIVFAPVGD
LVLPACEALNRGGTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHHIAVTTPEYPLEQADQALT
DLSVGRISGAAVLLA

Sequences:

>Translated_335_residues
MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLVAVRACGVCRTDLHVAEGDLPVHREHVTPGHEVVGEVLGVGSDVDAA
AGFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSRYTGWDVDGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGY
RSLLRSELPPGGRLGIYGFGGSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVADLPPVPLDAAIVFAPVGD
LVLPACEALNRGGTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHHIAVTTPEYPLEQADQALT
DLSVGRISGAAVLLA
>Mature_335_residues
MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLVAVRACGVCRTDLHVAEGDLPVHREHVTPGHEVVGEVLGVGSDVDAA
AGFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSRYTGWDVDGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGY
RSLLRSELPPGGRLGIYGFGGSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVADLPPVPLDAAIVFAPVGD
LVLPACEALNRGGTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHHIAVTTPEYPLEQADQALT
DLSVGRISGAAVLLA

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=31.2302839116719, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082401, Length=319, Percent_Identity=28.5266457680251, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1790045, Length=278, Percent_Identity=30.9352517985612, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI226510992, Length=169, Percent_Identity=30.1775147928994, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786518, Length=332, Percent_Identity=26.8072289156627, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=28.8461538461538, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787863, Length=146, Percent_Identity=31.5068493150685, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082125, Length=195, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=322, Percent_Identity=27.3291925465839, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=332, Percent_Identity=26.8072289156627, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=332, Percent_Identity=26.5060240963855, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=333, Percent_Identity=30.6306306306306, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=32.02416918429, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=28.8753799392097, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=29.483282674772, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323980, Length=199, Percent_Identity=32.1608040201005, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319949, Length=190, Percent_Identity=36.3157894736842, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35490; Mature: 35490

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLVAVRACGVCRTDLHVAEGDLPVHREHV
CCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHCCCEEECCCCCCCCCCC
TPGHEVVGEVLGVGSDVDAAAGFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSRYTGW
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
DVDGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGYRSLLRSELPPGGRLGIYGFG
CCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVADLPPVPLDAAIVFAPVGD
CCCHHHEEEEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECHHH
LVLPACEALNRGGTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQ
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
HHIAVTTPEYPLEQADQALTDLSVGRISGAAVLLA
CCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLVAVRACGVCRTDLHVAEGDLPVHREHV
CCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHCCCEEECCCCCCCCCCC
TPGHEVVGEVLGVGSDVDAAAGFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSRYTGW
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
DVDGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGYRSLLRSELPPGGRLGIYGFG
CCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVADLPPVPLDAAIVFAPVGD
CCCHHHEEEEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECHHH
LVLPACEALNRGGTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQ
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
HHIAVTTPEYPLEQADQALTDLSVGRISGAAVLLA
CCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]